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Sensors & Transducers Journal, Vol.76, Issue 2, February 2007pp.935-936

 

 

 

 

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ISSN 1726-5479

© 2007 by IFSA

http://www.sensorsportal.com

 

 

 

 

 
 
 
 
 

Biosensors: Future Analytical Tools 

 

Vikas, Anjum and C S Pundir* 

Department of Biochemistry & Genetics, Maharashi Dayanand University, Rohtak-124001, India 

Tel.: 00 91 09215570591; e-mail: [email protected]

 

 

Received: 10 October 2006 /   Accepted: 22 February 2007 /   Published: 26 February 2007 

 
 
 
Abstract: 

Biosensors offer

 

considerable promises for attaining the analytic information

 

in a faster, 

simpler and cheaper manner compared to conventional assays. Biosensing approach is rapidly 
advancing and applications ranging from metabolite, biological/ chemical warfare agent, food 
pathogens and adulterant detection to genetic screening and programmed drug delivery have been 
demonstrated.

 

Innovative efforts,

 

coupling micromachining and nanofabrication

 

may lead to even more 

powerful devices that would accelerate

 

the realization of large-scale and routine screening. With 

gradual increase in commercialization a wide range

 

of new biosensors are thus expected to reach

 

the 

market in the coming years. 
 

Keywords: 

Electrode, transducers, genetic screening, food analysis, bioterrorism, environment 

monitoring 

 
 
 

1. Introduction 

 
Modern economy is technology driven, promising revenues that are mind-boggling. Biosensor is one 
such product of biotechnology that is becoming increasingly popular in fields like environmental 
monitoring [1-2], bioterrorism [2-3], food analyses [4]

 

and most importantly in the area of health care 

and diagnostics [5]. This rapidly expanding field has an annual growth rate of 60 %, with major 
impetus from the health-care industry (30% of the world’s total analytical market) supported with 
other analytical areas of food & environmental monitoring including defense needs [6]. There is 
clearly a vast market exponential potential as less than .1% of this market is currently using biosensors. 
Research & Development in this field is wide and at the forefront of multidisciplinary science that 
involves the collaboration of physics, chemistry, biology, nanotechnology, electronics and software 
engineering. The concept of biosensors is just four decades old and the feasibility of biosensing was 
first demonstrated by an American scientist Leland C. Clark in 1962. He described how to make 
electrochemical sensors more intelligent by adding "enzyme transducers as membrane enclosed 

 

937

Содержание Sensor

Страница 1: ......

Страница 2: ...n Chiriac Horia National Institute of Research and Development Romania Chowdhuri Arijit University of Delhi India Chung Wen Yaw Chung Yuan Christian University Taiwan Corres Jesus Universidad Publica de Navarra Spain Cortes Camilo A Universidad de La Salle Colombia Courtois Christian Universite de Valenciennes France Cusano Andrea University of Sannio Italy D Amico Arnaldo Università di Tor Vergat...

Страница 3: ...e Cataluna Spain Rothberg Steve Loughborough University UK Royo Santiago Universitat Politecnica de Catalunya Spain Sadana Ajit University of Mississippi USA Sandacci Serghei Sensor Technology Ltd UK Sapozhnikova Ksenia D I Mendeleyev Institute for Metrology Russia Saxena Vibha Bhbha Atomic Research Centre Mumbai India Schneider John K Ultra Scan Corporation USA Seif Selemani Alabama A M Universit...

Страница 4: ...Solid State Piezoelectric Transducer Chemical Sensor for Chromium Ions Contamination in Water Selemani Seif 991 I In nf fl lu ue en nc ce e o of f L Li iq qu ui id d P Pe et tr ro ol le eu um m G Ga as s o on n t th he e E El le ec ct tr ri ic ca al l P Pa ar ra am me et te er rs s o of f t th he e W WO O3 3 T Th hi ic ck k F Fi il lm m R S Khadayate J V Sali and P P Patil 1001 Synthesis Character...

Страница 5: ...sensors are thus expected to reach the market in the coming years Keywords Electrode transducers genetic screening food analysis bioterrorism environment monitoring 1 Introduction Modern economy is technology driven promising revenues that are mind boggling Biosensor is one such product of biotechnology that is becoming increasingly popular in fields like environmental monitoring 1 2 bioterrorism ...

Страница 6: ... or intimately associated to the second major component of biosensors that is a transducer via immobilization adsorption cross linking and covalent bonding so that the close proximity of the biological component to the transducer is achieved This is necessary so that the transducer can rapidly and easily generate the specific signals in response to the undergoing biochemical interactions secondly ...

Страница 7: ...sensors also offer enormous potential in detecting wide range of analytes that are regularly needed to show a patient s metabolic state especially for those who are hospitalized more so if they are in intensive care Critical care is one of the most challenging and stressful areas of medicine in the sense that the decision makers primarily doctors nurses and ambulance staff must take their decision...

Страница 8: ...st recently Luminescent semiconductor nanocrystals or quantum dots QD have been used as labels for bioanalytical applications 34 35 Thermoquenching and extremely high cost are potent disadvantages of Quantum dots and hence generally limited to use in sensitive research experiments There fore large scale routine clinical screening based on gene diagnostics is limited by the current available techno...

Страница 9: ...is an uncertain and doubtful strategy Because of this food industry needs instruments which will simultaneously monitor the parameters of production lines and report data to the computer for feedback control Most of the electrodes used in biosensors are often based on the measurement of O2 consumption because there are at least 50 known oxidases acting on fatty acids hydroxy acids sugars amino aci...

Страница 10: ... to micro µ level may permit continuous on line monitoring of critical blood chemistries and has the advantage of creating less blood to clean up hence reducing the potential for infectious contamination from patient blood It is anticipated that the health care worker at the bedside of a hospital patient µl aliquot of whole blood directly into the chip and insert the chip into a portable biosensor...

Страница 11: ... T Gregory Drummmond Electrochemical DNA sensors Nature Biotechnol 21 2003 pp 1192 1199 11 Robert M Umek Electronic detection of Nucleic acids J of Mol Diagnostics 3 2001 pp 74 84 12 KC Ho CY Chen HC Hsu LC Chen SC Shiesh and XZ Lin Amperometric detection of morphine at a prussian blue modified indium tin oxide electrode Biosens Bioelectron 20 2004 pp 3 8 13 I Ben Dov I Willner and E Zisman Piezoe...

Страница 12: ...5 W C Chan and S Nie Quantum dot bioconjugates for ultrasenstive nonisotopic detection Science 281 1998 pp 2008 2016 36 M Minunni S Tombelli R Seielzi I Mnelli C Mascini Mand Gaodiano Detection of β thalassemia by a DNA piezoelectric biosensor coupled with polymerase chain reaction Anal Chim Acta 481 2003 pp 55 64 37 K M Millan Saraullos and S R Mikkelssen Valtammetric DNA biosensor for cystic fib...

Страница 13: ... transducers and sensor instrumentations Topics include but are not restricted to Physical chemical and biosensors Digital frequency period duty cycle time interval PWM pulse number output sensors and transducers Theory principles effects design standardization and modeling Smart sensors and systems Sensor instrumentation Virtual instruments Sensors interfaces buses and networks Signal processing ...

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