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NIPE Monitor V1 - Continuous monitoring system of comfort
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discomfort for newborn infants
MD/PRD/IN16.NIPEV1 v.10 - 12 MAR 2020
8
Fragile; handle with care
Caution: Federal law restricts
this device to sale by or on the
order of a (licensed healthcare
practitioner)
This way up
2 Presentation of the NIPE Monitor V1
NIPE (Newborn Infant Parasympathetic Evaluation) is a normalized and continuous measure
of the parasympathetic tone (p
) which is a part of the autonomous system (ANS). It uses the
punctual and quick increase of pƩ tone induced by each respiratory cycle (spontaneous or
artificial) to measure the “relative quantity” of pƩ tone.
These rapid changes in pƩ tone express in the sinus node of the heart by changes in the time
intervals between two R waves of the electrocardiogram. The pƩ component is evaluated after
filtering, normalization and resampling of the RR series by measuring the area generated by
the respiratory patterns. More important is the pƩ tone, bigger is the measured area.
Rapid p
tone variations express themselves directly on the sinus node by variations of time
interval separating two R waves on the electrocardiogram. The normal next RR series
(stemming from a cardiac cycle and not from an extrasystole) establish the RR series. After
filtering, normalization and resampling, the p
Ʃ
compound of the RR series is obtained by
measuring the generated surface by the respiratory cycles.
NIPE measurement cannot be interpreted in the following situations:
•
Non-sinus cardiac rhythm;
•
cardiac graft;
•
drugs affecting the sinus node (Atropine…);
•
post-conceptional age lower than 26 weeks.
The NIPE index is expressed on a scale between 0 and 100. It reflects the activity of the
parasympathetic nervous system. It gives a reading of the proportion of pƩ tone compared to
the Ʃ tonus in the autonomous nervous system. The NIPE displayed represents the