biochrom Libra S21, Руководство пользователя

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Issue 02 - 04/2004
Libra S21/S22, English 25
Good Laboratory Practice
Good laboratory Practice (GLP) concerns being able to trace experimental results to an
instrument, an operator and the time the result was obtained so that a laboratory can
prove that the instrument was functioning correctly or not. Laboratory, operator and
internal instrument reference names can be entered on the spectrophotometer.
If the GLP option is on, during calibration or re-calibration the instrument self-checks its
integrity for GLP purposes. The GLP test of this instrument is essentially a “confidence
test” that it is performing as it was when manufactured and tested. For absolute
measurements, an annual certification service agreement with your supplier is
recommended. The integrity of the instrument for GLP purposes is quantified from:
•
the calibration status of the instrument
•
the bandwidth (this is assessed during calibration by measuring the zero order beam
width)
•
the wavelength accuracy by comparing to the 881.9 nm xenon emission line
•
the values of built in absorbance filters compared to when the instrument was
manufactured (or last serviced by an accredited engineer)
•
the instrumental stray light
The expected values are given in parentheses on the GLP print out after calibration; the
range of acceptance is defined by the technical specification of the instrument.
In the unlikely event that the instrument fails calibration or goes out of specification, a
message will appear on the display. In this event, the following should be checked:-
•
is the cell compartment lid closed properly
•
is a sample in the light beam - if so, remove it
•
is the baseplate plug in place (single cell accessory)
•
is the in-fill panel at the front of the cell compartment in place
Pressing OK after the message "GLP Calibration Fail" appears confirms that you
have accepted the instrument status. If you are working in a regulated environment
such as a drug discovery laboratory that generates data for GLP/GMP activities or
reports, you should not use the instrument and contact your local service engineer.