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Quick Reference Cards  |  

CG000471  |  Rev D

5

Chromium X Series (X/iX)

Firmware Update Procedure

Step 1: Download and install the update

Procedure with a network connection, auto-download 
enabled:

Automatic downloads of updates are enabled after 
firmware updates to ensure the instrument is up-to-date 
with the latest assay products, features, and bug fixes.

a. 

A pop-up on the home screen will alert the 

user of available updates.

b. 

Open pop-up and click to install.

Procedure with a network connection, auto-download 
disabled:

a. 

A pop-up on the home screen will alert the 

user of available updates.

b. 

Open pop-up and click to download.

c. 

Once the update has been downloaded, 

install the update.

Procedure with an instrument not connected to the 
internet:

a. 

Visit 

cloud.10xgenomics.com

 and log into 

an account to which the instrument is 

registered.

b. 

Navigate to the Instruments page using the 

top left dropdown button.

c. 

Download the latest firmware update onto 

a USB drive using the “Download Latest 

Firmware” button. 

Firmware updates are linked to specific instruments. If 
the chosen account is linked to multiple instruments, 
select the correct download link for the desired serial 
number.

The Chromium X Series instrument is compatible with 

VFAT, FAT32, a

nd exFAT formatted USBs.

d. 

Insert USB into the USB port. 

e. 

Onscreen, navigate through the menu to 

System > Firmware Update > Update via 

USB.

f. 

Follow the onscreen instructions to update 

your instrument using a USB drive.

g. 

After installation is complete, remove USB 

from instrument.

Step 2: Reinitialize the instrument

After installing an update, run a Readiness Test. See 

Readiness Test 

section for further guidance.

a. 

Retrieve the shipping/readiness test block 

with attached blank gasket.  

See th

Readiness Test

 section for more information 

on the block.

b. 

Initiate a readiness test through the home 

screen by loading the  block into the 

instrument.

c. 

After the test is complete, follow screen 

instruction to remove the  block from the 

tray. 

d. 

Store the assembled block and gasket in 

a plastic bag, away from sun-light and 

extreme temperature. Retain for future use.

e. 

The instrument is now ready for use.

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