7
6
ClearUP works in several ways.
• Microcurrent is emitted from the tip of the unit
to the nerves under the facial sinus passages.
• Electrical stimulation of nerves reduces feelings
of sinus pain for up to 6 hours according to our
clinical study.
(This study has not been reviewed by the FDA)
• Published research has shown that electrical
stimulation can also shrink swollen tissue –
swelling is often a key cause of nasal and sinus
symptoms.
1-4
Note:
ClearUP must be self-administered and cannot be applied to
another person. This is due to the electrical circuit design.
How It Works
Pivotal Clinical Study:
A top-tier U.S. science
research center conducted a double-blinded,
randomized controlled clinical study using the
ClearUP Sinus Pain Relief device. Included were
27 sinus pain subjects with Chronic Rhinosinusitis,
49 patients suffering from Allergic Rhinitis, 5 subjects
with other sinus conditions. Each subject used the
device on the outside of their sinus passages without
any assistance for a single five-minute treatment.
Each subject rated their level of pain before and ten
minutes after treatment.
Note:
24% who used the microcurrent device experienced sinus pain
reduction of 3 points or more on the visual analog pain scale (0 no pain
to 10 severe pain). Only one subject experienced minor reddening of
the skin which disappeared within minutes.
Post-market clinical study:
Conducted at the
Asthma Allergy Associates in Santa Clara, CA,
subjects received a five-minute treatment in office,
followed by 4 weeks of at-home use.
(This study has not been reviewed by the FDA).
Powerful Clinical Study Results
74
%
3 out of 4 got relief
82
%
43
%
preferred ClearUP
reduction in sinus
pain after 4 weeks
Up to 6 hrs pain relief
would recommend
ClearUP
6
hours
Two key clinical studies and FDA clearance demonstrated
that ClearUP is a safe and effective treatment.
77
%
Nerve
Pathways
1. Goldsobel, Alan B., Niveditha Prabhakar, and Blake T. Gurfein.
“Prospective trial examining safety and efficacy of microcurrent
stimulation for the treatment of sinus pain and congestion.”
Bioelectronic Medicine 5.1 (2019): 1-9.
2. Mandel, Yossi, et al. “Vasoconstriction by electrical stimulation:
new approach to control of non-compressible hemorrhage.”
Scientific reports 3 (2013).
3. Franco, O. S., et al. “Effects of different frequencies of
transcutaneous electrical nerve stimulation on venous vascular
reactivity.” Brazilian Journal of Medical and Biological Research
47.5 (2014): 411-418.
4. Malm, L. “Stimulation of sympathetic nerve fibres to the nose in
cats.” Acta oto-laryngologica 75.2-6 (1973): 519-526.
