Chapter |
Introduction
Confidential, limited rights
PN 103261 | Revision D | 23-Oct-2019
User Manual
Page
3
1
Introduction
The Vitrobot
TM
(Vitrification Robot) is a fully PC-controlled device for vitrification (= rapid
cooling) of aqueous samples. Minimal, yet essential, training is required when operating the
instrument for research purposes in a laboratory environment. The process of plun ging,
blotting and vitrification is fully automated upon placing a vial in the chamber and setting up
the ethane holder. Operation is strictly controlled by dedicated hardware and software,
implying that parameters and the results are reproducible. This en ables a high throughput of
vitrified samples, with an easy and straightforward control of the vitrification process. The
parameters to be influenced are: temperature, humidity, the number of blots, and a number of
critical time settings. The instrument will consistently produce excellent specimens for
cryo-electron microscopy. Research can now rely on specimen preparation allowing the
investigator to concentrate on structural studies of the specimen.
Summary of Contents for Vitrobot Mk IV
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