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SP Scientific VIRTIS ADVANTAGE PRO, Operator'S Manual, Page: 2 / 78

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Summary of Contents for VIRTIS ADVANTAGE PRO

Page 1: ...FREEZE DRYER OPERATOR S MANUAL VIRTIS ADVANTAGE PRO LABORATORY BENCHTOP FREEZE DRYER...

Page 2: ......

Page 3: ...ses specified by SP Scientific Reproduction of dissemination of modifications to or the creation of derivative works from this Freeze Dryer Operator s Manual by any means and in any form or manner is...

Page 4: ...uthorized technician services the refrigeration heat transfer vacuum and electrical systems Always ensure that refrigeration air intake is clear and clean Always ensure vacuum pump exhaust is properly...

Page 5: ...sole expense The Company shall not be responsible for labor charges payable with respect to persons other than Company employees Replacement or repair of parts pursuant to this warranty shall not in...

Page 6: ...iv Rev 002 01 14 SP Scientific 2014...

Page 7: ...ze Dryer 6 AdVantage Pro Setup 6 Service Connections 6 Vacuum Pump Installation 7 Installing the Vacuum Pump 7 Product Preparation Shelf Drying 8 Stoppering 9 Inert Gas Backfill 9 To Backfill with Ine...

Page 8: ...ng the Vacuum Pump Maintenance Alarm 24 Optional Secondary Traps 25 Gas Ballast Valve on the Vacuum Pump 25 Vacuum Tubing and Gaskets 25 Quickseal Valves 27 Refrigeration System 27 Air Cooled Condense...

Page 9: ...VirTis AdVantage Pro Contents Rev 002 01 14 vii SP Scientific 2014 Protective Cover for Intellitronics Controller 66...

Page 10: ......

Page 11: ...all aspects of the freeze dry cycle The AdVantage Pro freeze dryer offers an optional pneumatic stoppering system for stoppering vials and is available with up to three 3 usable product drying shelves...

Page 12: ...AdVantage Pro 2 Rev 002 01 14 SP Scientific 2014 AdVantage Pro Series Freeze Dryer AdVantage Pro Front View AdVantage Pro Side Views Drain Intellitronics Controller Product Drying Shelves Manifold Ad...

Page 13: ...02 01 14 3 SP Scientific 2014 AdVantage Pro Rear View Serial Tag Network Port Main Power Inlet Vacuum Pump Outlet Port Inert Gas Backfill Port Stoppering Air Inlet Connection Vacuum Break Solenoid VBS...

Page 14: ...Introduction VirTis AdVantage Pro 4 Rev 002 01 14 SP Scientific 2014...

Page 15: ...ED NOTIFICATION OF DAMAGES Upon receiving your shipment inspect all contents of your equipment for damage Check packing material for small accessory items Remove all packing material carefully and ins...

Page 16: ...el on the desired location Allow sufficient space so the unit may be easily connected and ensure that the area around the unit provides for adequate air circulation The back of AdVantage Pro should be...

Page 17: ...bing are required for connection to the vacuum pump If you need assistance please contact SP Scientific For more information on Oil Mist Eliminators please contact SP Scientific Installing the Vacuum...

Page 18: ...ity If desired insert product probes into the product For accurate temperature 2 readings probe ends should make point contact with the bottom of the container at the bottom of the product 3 If your u...

Page 19: ...rvice panel of your unit Note A BSPT to 1 4 inch NPT adapter shall be provided with the unit This allows users to choose between a 1 4 inch BSPT fitting and a 1 4 inch NPT fitting Inert Gas Backfill F...

Page 20: ...eld A numeric keypad will open 4 Note The Actual vacuum pressure is displayed next to the Vacuum Set Point Press the keypad buttons to enter the desired Vacuum pressure 5 Press the Esc button to close...

Page 21: ...lower and raise the shelves during stoppering but also to support the shelves during the Drying phase A manual valve may be installed to limit pressure drops and allow the air source to be shut off or...

Page 22: ...n to begin compressing the shelves and fully inserting partially inserted stoppers into the product vials Once the Stoppering Down button can no longer be pressed press and hold the Stoppering Up butt...

Page 23: ...ing They permit the attachment of flasks for in vitro freeze drying and are also used to break vacuum after a cycle completes Quickseal valves operate as follows Note Quickseal valves are an integral...

Page 24: ...bath or shell bath 2 freezer Freezing to 40 C 40 F is adequate for most products 6 5 Wide Mouth Flasks are the most popular glassware type but other types of flasks vials and ampoules are available I...

Page 25: ...r within 20 minutes The duration between adding flasks should be spaced accordingly to avoid possible condenser overload and or periods of poor vacuum Open the Quickseal valve by turning the white sel...

Page 26: ...revent meltback Note These guidelines only apply to drying product in flasks Decrease the volume and depth of the product or the number of samples connected Insulate the product container to decrease...

Page 27: ...figurations that vary based on the height of the vials that are being used The configuration of these trays are W x D x H Vials 1 in 25 4 mm 10 x 14 x 75 in 254 x 355 6 x 19 1 mm Vials 1 1 5 in 25 4 3...

Page 28: ...helf latching kit will reduce the total number of usable shelves while increasing shelf clearance For further information on shelf clearance refer to your unit specifications For shelf latching instru...

Page 29: ...use adequate ventilation to protect from gaseous vapors WARNING THE LIQUID NITROGEN WILL EXPAND AND BUBBLE WHEN IT MEETS THE WARM CENTER WELL WEAR PROTECTIVE EYEWEAR AND GLOVES TO AVOID CONTACT WITH...

Page 30: ...idge Most filters require an overnight degassing to achieve proper vacuum To degas the filter trap cartridge Unscrew the clear polypropylene housing from the white plastic top 1 To begin degassing ena...

Page 31: ...zer Note A power strip is not included with the lab cart Condenser Drain Tray A condenser drain tray is available with your AdVantage Pro for easier removal of defrosted condensate Replacement Door Ga...

Page 32: ...Additional Options VirTis AdVantage Pro 22 Rev 002 01 14 SP Scientific 2014...

Page 33: ...ntific recommends the following protocols for vacuum pump maintenance For additional information refer the operator s manual for your specific vacuum pump Clean oil is necessary for optimal vacuum and...

Page 34: ...est cycle Have a qualified technician check the oil after the test cycle If the oil appears dirty you may need to change the oil after every use If the oil appears clean check the oil again after two...

Page 35: ...and concentration changing the charcoal cartridge every three 3 to six 6 months may suffice Gas Ballast Valve on the Vacuum Pump The gas ballast valve removes some contaminants from the pump oil Duri...

Page 36: ...dry rot rippling on the 4 inside of the gasket it should be replaced immediately Note For information regarding a replacement door gasket contact SP Scientific Always install door gaskets on a clean g...

Page 37: ...acceptable selector s and 6 reassemble Repeat steps 1 6 for all remaining Quickseal valves 7 Refrigeration System Air Cooled Condenser It is very important to keep the air cooled condenser clean This...

Page 38: ...is will allow internal pressures to equalize The AdVantage Pro s cover will need to be removed to allow the high and low side access valves to be visible If the actual system pressure matches the pres...

Page 39: ...cessory ports valves or filters closed tightly Is the door gasket clean and properly greased Are all the Quickseal valves in the closed position if applicable Are the Quickseal valves in good conditio...

Page 40: ...hreaded and welded connections and seal with vacuum sealant 3 If poor vacuum persists or testing vacuum with a second calibrated gauge indicates a good vacuum reading the problem is likely related to...

Page 41: ...and gaskets To remove the cover ENSURE THAT YOUR UNIT IS POWERED OFF AND UNPLUGGED PRIOR TO REMOVING THE COVER If a drain line is fitted to your unit s drain valve disconnect the line from the 1 valve...

Page 42: ...ve the four 4 screws from the manifold adapter 3 Remove the manifold adapter and the centering ring 4 Remove the door bracket and top hinge bracket connector screw 5 Centering Ring Top Hinge Bracket D...

Page 43: ...ds open the door to the fully open position 6 Rotate the door bracket 180 degrees clockwise from the default position 7 Push the top of the door towards the unit to separate the door from the top 8 hi...

Page 44: ...inge bracket 9 pin CAUTION ONCE REMOVED MISHANDLING OF THE PRODUCT CHAMBER DOOR MAY LEAD TO DAMAGE Remove the washer on the bottom hinge bracket 10 Remove the chamber door seal 11 Remove the four 4 sc...

Page 45: ...MAGE TO THE DRAIN VALVE AND POWER SWITCH DO NOT PULL THE COVER FROM JUST ONE SIDE WHEN REMOVING IT FROM THE UNIT CAUTION ONCE REMOVED MISHANDLING OF THE COVER MAY LEAD TO DAMAGE Once the necessary mai...

Page 46: ...Appendix B Cover Removal VirTis AdVantage Pro 36 Rev 002 01 14 SP Scientific 2014...

Page 47: ...Cylinder Rod is fully extended 2 Remove the four 4 upper shoulder screws Item C and install the latching 3 rod extensions Item A Remove only the upper shoulder screws installed in the four 4 corners...

Page 48: ...screws Item C and install latching rod 3 extensions Item A Remove only the upper shoulder screws installed in the four 4 corners of the top two 2 shelves Replace and secure the eight 8 upper shoulder...

Page 49: ...y 179077 9 35 18 2 285 179275 10 85 12 2 560 179101 9 40 22 6 202 179085 47 23 5 174 179143 9 50 23 10 174 179135 54 26 10 143 178855 9 62 28 20 120 178830 58 33 20 80 178897 63 37 30 63 178921 73 43...

Page 50: ...VirTis AdVantage Pro 40 Rev 002 01 14 SP Scientific 2014 Appendix D Serum Vial Capacities...

Page 51: ...olished finish May scratch No 2 mil and Nos 7 and 8 polished finishes TENACIOUS DEPOSITS RUSTY DISCOLORATIONS INDUSTRIAL ATMOSPHERIC STAINS Oakite No 33 Dilac Texo 12 Texo N Y Flash Klenz Caddy Cleane...

Page 52: ...Appendix E Stainless Steel Cleaners VirTis AdVantage Pro 42 Rev 002 01 14 SP Scientific 2014...

Page 53: ...e Commercial Grade R Sodium Hydroxide 1 R Benzyl Alcohol NR Hydrochloric Acid NR Sodium Hydroxide 10 R Butyl Acetate NR Hydrofluoric Acid 40 R Sodium Hydroxide 60 R Calcium Chloride Sat R Hydrogen Per...

Page 54: ...Acetyl Salicylic Acid SE Acid Fumes SE Alcohols SE Aliphatic Esters SE Alkyl Chlorides SE Alum EX Aluminium Chloride EX Aluminium Sulphate EX Ammonia Anhydrous EX Ammonia Aqueous EX Ammonium Chloride...

Page 55: ...lic Acids 50 SE Cyclohexane SE Detergents Synthetic EX Emulsifiers Concentrated ND Esters SE Ether SE Fatty Acids C6 EX Ferric Chloride EX Ferrous Sulphate EX Fluorinated Refrigerants SE Fluorine dry...

Page 56: ...nol SE Methylene Chloride SE Milk Products EX Moist Air EX Molasses EX Monoethanolamine SE Naptha EX Napthalene SE Nickel Salts EX Nitrates of Na K and NH3 EX Nitric Acid 25 SE Nitric Acid 50 SE Nitri...

Page 57: ...hloride SE Starch EX Sugar Syrups Jams EX Sulphamic Acid ND Sulphates Na K Mg Ca EX Sulphites EX Sulphonic Acids ND Sulphur EX Sulphur Dioxide dry EX Sulphur Dioxide wet EX Sulphur Dioxide 96 SE Sulph...

Page 58: ...bon Tetrachloride Very Slightly Whitened 30 Nitric Acid No Change Toluene Attacked 10 Nitric Acid No Change Heptane No Change 10 Citric Acid No Change Tichloroethylene Attacked 5 Acetic Acid No Change...

Page 59: ...oniz Wax No Change Very Slight Household Ammonia No Change None All Detergent No Change None Exxon Gasoline No Change Very Slight Mennen Skin Bracer No Change None Tomato Juice No Change Very Slight P...

Page 60: ...etyl Chloride dry NR NR ND ND Acetyl Salicylic Acid ND ND ND ND Acetylene R R ND R Adipic Acid R R R R Alcohols ND ND ND ND Aliphatic Esters ND ND ND ND Alkyl Chlorides ND ND ND ND Allyl Alcohol ND ND...

Page 61: ...ide R NR ND NR Anise Oil ND ND ND ND Anitfreeze ND ND ND R Antimony Trichloride ND ND ND R Aqua Regia LR NR ND LR Aromatic solvents ND ND ND ND Arsenic ND ND ND ND Arsenic Acid ND R ND R Ascorbic Acid...

Page 62: ...ND Butyric Acid ND ND NR NR Calcium Bisulfide ND ND ND R Calcium Bisulfite NR R ND R Calcium Carbonate ND ND ND R Calcium Chlorate ND ND ND R Calcium Chloride 10 ND ND R R Calcium Disulphide ND ND ND...

Page 63: ...e Oil NR ND ND ND Cresol NR LR NR NR Cresylic Acids 50 ND ND ND NR Cupric Acid ND ND ND ND Cyanic Acid ND ND ND ND Cycloheaxanol LR R ND NR Cyclohexane NR LR R NR Cyclohexanone GR NR ND NR Cyclohexene...

Page 64: ...horide LR NR NR NR Ethyl Ether LR LR NR NR Ethyl Sulfate ND ND ND ND Ethylene Chloride LR NR NR NR Ethylene Chlorohydrin R R ND NR Ethylene Diamine R R ND R Ethylene Dibromide ND ND ND LR Ethylene Dic...

Page 65: ...Hydrochloric Acid conc ND ND ND R Hydrochloric Acid 2 ND ND R ND Hydrochloric Acid 36 ND ND R ND Hydrocyanic Acid ND R ND R Hydrocyanic Acid 75 ND ND ND R Hydrocyanic Acid 30 ND ND LR R Hydrogen Bromi...

Page 66: ...ium Sulfate R R ND R Maleic Acid R LR ND R Maleic Anhydride R LR ND ND Malic Acid R LR ND R Manganate Potassium K ND ND ND ND Manganese Sulphate ND ND ND LR Melamine ND ND ND ND Mercuric Chloride R R...

Page 67: ...e R R ND R Nickel Nitrate ND ND ND R Nickel Salts ND ND ND ND Nickel Sulfate R R R R Nitrates of Na K and NH3 ND ND ND ND Nitric Acid 25 ND ND R R Nitric Acid 50 ND ND R NR Nitric Acid 90 ND ND LR NR...

Page 68: ...ND ND R Potassium Bromide ND ND ND R Potassium Carbonate ND ND ND R Potassium Chlorate ND ND ND R Potassium Chloride R R R R Potassium Chromate ND ND ND R Potassium Cyanide Solutions R R ND R Potassi...

Page 69: ...R Sodium Bromide ND ND ND R Sodium Carbonate 10 ND ND R R Sodium Chlorate ND ND ND R Sodium Chloride 10 ND ND R R Sodium Chromate ND ND ND R Sodium Cyanide R R ND R Sodium Dichromate ND ND ND R Sodium...

Page 70: ...6 ND ND ND ND Sulphur Dioxide dry R NR ND R Sulphur Chlorides NR LR ND NR Sulphur Dioxide wet R R ND NR Sulphur Trioxide R NR ND NR Tallow ND ND ND ND Tannic Acid 10 ND ND ND R Tanning Oil ND ND ND ND...

Page 71: ...NR NR Urea Aqueous ND ND R R Urine ND ND ND R Varnish NR NR ND R Vaseline ND ND R ND Vegetable Oil LR LR ND R Vinegar ND R ND R Wax Molten ND ND R ND Whey ND ND ND ND Wine Brandy ND ND R ND Xylene NR...

Page 72: ...umes R Alcohols R Aliphatic Esters R Alkyl Chlorides R Alum R Aluminium Chloride R Aluminium Sulphate R Ammonia Anhydrous R Ammonia Aqueous R Ammonium Chloride R Amyl Acetate R Aniline R Aromatic Solv...

Page 73: ...uorinated Refrigerants R Fluorine dry NR Flourine wet NR Fluorosilic Acid R Formaldehyde 40 R Formic Acid R Fruit Juices R Gelatine R Glycerine R Glycols R Glycol Ethylene R Glycolic Acid R Hexamethyl...

Page 74: ...nd NH3 R Nitric Acid 25 R Nitric Acid 50 R Nitric Acid 90 NR Nitric Acid fuming NR Nitrite Na R Nitrobenzene NR Oils Diesel R Oils Essential R Oils Lubricating Aromatic Additives R Oils Mineral R Oils...

Page 75: ...K Mg Ca R Sulphites R Sulphonic Acids ND Sulphur R Sulphur Dioxide dry R Sulphur Dioxide wet R Sulphur Dioxide 96 R Sulphur Trioxide NR Sulphuric Acid 50 R Sulphuric Acid 70 R Sulphuric Acid 95 R Sulp...

Page 76: ...al resistances Chemical Chemical Chemical Chemical Acetone 40 NaOH Top Job1 Ketchup MEK Concentrated HCl Fantastik2 Tea Toluene Gasoline Regular Formula 4093 Tomato Juice Methylene Chloride Gasoline U...

Page 77: ...VirTis AdVantage Pro Appendix F Chemical Resistance Charts Rev 002 01 14 67 SP Scientific 2014...

Page 78: ...A 800 251 1531 845 687 0071 935 Mearns Road Warminster PA 18974 USA 800 523 2327 215 672 7800 815 State Route 208 Gardiner NY 12525 USA 800 431 8232 845 255 5000 The Sovereign Centre Farthing Road Ips...

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