17
Start up of cassettes
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Assemble system as shown on the diagram.
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Open V
2
, V
3
, V
4
and V
1
, close V
5
.
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Install cassettes into filter holder.
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Attach a RO water source to the feed line.
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Rinse cassette with RO water for 5 minutes at an inlet pressure of 29 psi|2 bar|
200 kPa and retentate pressure of 7 psi|0.5 bar|50 kPa. Adjust valve settings to
achieve pressure values if needed.
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Drain the system.
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Close valve V
2
. Connect V
2
at the retentate line with a steam generator.
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Exchange the normal operation torque nuts to the pressure compensating torque
nuts. For specific information related to the filter holder see user manual of the
installed filter holder.
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Use a torque wrench to tighten the pressure compensation nut to the first notch
(see picture).
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Close valve V
3
and V
4
on the permeate outlets as well as V
5
.
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Adjust the steam generator pressure to 14.5 psi|1.0 bar|100 kPa, and slowly open
valve V
2
to initiate steam flow in to the system.
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We highly recommend the installation of condensate run off valves. The following
step has to be incorporated if no condensate run off valves are used. Reduce V
1
valve setting on the feed line to allow a small amount of steam to exit the system.
Slowly start to increase pressure build up to 14.5 psi|1.0 bar|100 kPa by closing V
1
.
A small amount of steam has to remain exiting the system, which means V
1
will
not be closed completely.
The feed pressure must not exceed 14.5 psi|1.0 bar|100 kPa at 121°C.
If inline pressure gauges are used, please consider that high temperatures may
cause the display to be inaccurate. Usually the actual pressure is lower than
indicated. Make sure the pressure is correctly monitored during your validation
procedure.
Pressure compensating torque nuts
First notch
(steaming position)
Second notch
(processing position)
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We highly recommend the installation of condensate run off valves. The following
step has to be incorporated if no condensate run off valves are used. Once the feed
pressure P
1
has reached 14.5 psi|1.0 bar|100 kPa slowly start to open the permeate
valves V
3
|V
4
. A small amount of steam has to escape from each valve.
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Once the permeate pressure has reached 14.5 psi|1.0 bar|100 kPa the actual
sterilization begins.