QIAcube Connect MDx User Manual 12/2020
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General Description
The QIAcube Connect MDx performs fully automated isolation and purification of nucleic acids in
molecular diagnostic and molecular biology applications.
It can process of up to 12 samples per single run. The QIAcube Connect MDx is designed to
automate selected QIAGEN DSP and non-DSP kits and the PAXgene Blood RNA Kit. The QIAcube
Connect MDx controls integrated components, including a centrifuge, heated shaker, pipetting
system, UV LED and robotic gripper.
The QIAcube Connect MDx gives the option to start a protocol either in the IVD mode of the software
(for validated IVD applications only) or in the Research mode of the software (for Molecular Biology
Applications (MBA) only). The usage of IVD protocols is only possible and strictly restricted to the
IVD mode of the software. This User Manual focuses on operating the QIAcube Connect MDx in
the IVD-software mode. For detailed instructions on how to operate the QIAcube Connect MDx
using the Research mode of the software (with MBA-protocols or any customized protocols), please
refer to the User Manual of the QIAcube Connect (available on the QIAcube Connect product
webpage under the
QIAcube Connect MDx is preinstalled with various protocols for processing QIAGEN spin columns
for purification of RNA, genomic DNA and viral nucleic acids. In the Research mode of the software,
further protocols are available, for e.g. plasmid DNA and protein purification as well as DNA and
RNA cleanup. The user first selects the software mode for the type of application to be performed
using the touchscreen, then chooses an application or scans a kit barcode and loads labware,
samples, and reagents onto the QIAcube Connect MDx worktable. The user then closes the
instrument hood and starts the protocol, which provides all necessary commands for sample lysis
and purification using QIAGEN spin columns. A fully automated load check helps to ensure correct
loading of the worktable.
Offering an augmented user interface, users stay connected to their instrument through the built-in
screen and also remotely with a computer or a mobile device (e.g., a tablet) and the QIAsphere
App using the associated QIAsphere Connectivity Package (see section 10, Appendix B - QIAcube
Connect MDx Accessories), enabling quick response times and ability to monitor runs while being
away from the instrument.
Note
: Setup of a run on a mobile device (e.g., a tablet) and transfer of the information to the
QIAcube Connect MDx instrument is only possible with the Research mode of the software. The IVD
