Pall Allegro 50 L, Instructions For Use Manual

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4. The temperature of the jacket is controlled by controlling the temperature of the heat transfer
fluid and / or by regulating the flow rate of heat transfer fluid into the jacket.
Allegro 50 L jacketed mixer tote pressure drop <0.7 bar at 2 cubic meters/hr.
Achieve the desired temperature in the jacket through the thermal circuit (usually the temperature
of the product in the biocontainer). Temperature gauges can be attached to monitor temperatures
at the inlet and outlet of the Allegro jacketed tote or surface thermocouples can be used to
measure temperatures at the inlet and outlet.
WARNING!
Extreme care and precautions should also be taken while handling the heat transfer fluid
because of very high and low temperatures.
CAUTION!
Ensure all air is removed from the thermal circuit before starting recirculation of heat
transfer fluid.
The heat transfer fluid flow rate is adjusted according to the pressure ratings of the Allegro
jacketed mixer tote. Typical pressure drop is shown above.
CAUTION!
Ensure the feed and return lines are isolated and depressurized prior to removal.
The heat transfer fluid is drained through the jacketed tote drain valve following the operation
using the low point drain for heating and cooling fluids.
WARNINGS!
• Please note that the thermal circuit with the heat transfer fluid is started up before setting up
and filling the Allegro mixer biocontainer in the tote. All the necessary precautions must be in
place to regulate temperature and pressure. For example: temperature and pressure gauges
at inlet and outlet of the tote.
• Operation outside the specifications defined in the product data sheet may cause irreversible
changes to the product, personal injury and can result in damage to the equipment.
www.pall.com/biopharm 8
Hot/Cold Fluid Outlet
Hot/Cold Fluid Inlet
Hot/Cold Fluid Low
Point Drain