background image

M.I. P/N 004-2163 Rev. C 

20

Volume  

Display Conductance/Volume Units 

Use this button to change the display to conductance or volume units as desired.  This 
button does not affect the output voltage.   

Measured Volume 

This display indicates the current composite volume as measured by the MPVS 

Ultra

.  The 

value displayed is based upon an analog summation of all active segments.  This analog 
sum is the COMPOSITE output on the front panel.   

The blue or orange scale is a graphical representation of the composite volume signal.   

When the user opts to view units of volume (

μ

l or ml), the calculation of this value takes 

into account segment length, rho and alpha chosen on the Catheter Configuration tab. 

The output shown in the MPVS 

Ultra

 Control interface does not account for the volume 

attributed to parallel conductance of the myocardium.  If desired, this correction can be 
made in the PVAN 

Ultra

 software or the user’s acquisition software.

 

Transducer and Electronic Calibration Buttons 

The active button is green.  To measure a volume signal from the catheter, click the 

Transducer

 button. 

In order to calibrate the data acquisition system from voltage to volume or conductance 
units, the system has six internal sets of resistors that are used as inputs of known 
conductance.  Only two to three buttons are available at any given gain range.  (Available 
buttons are beige; others are gray.)  The available selections are designed to span the 
expected segmental conductance inputs for typical animals ranging from mice to domestic 
livestock.  The gain setting on the Catheter Configuration tab controls the available input 
range in order to maximize the use of the available voltage output range.  The indicated 
values on the buttons are the conductance or volume to be output by each segment, not the 
composite total. 

The values indicated on the calibration buttons change according to the present 
configuration.  When volume units are displayed, Baan’s equation is used, so the present 
values of alpha, rho, and segment length are used, as noted in Measured Volume above. 

Since the values on the buttons represent the per-segment conductance or volume, be sure 
to multiply by the number of active segments when entering the calibration value for the 
Composite Volume channel. The Composite Volume or Composite Conductance value is 
displayed by the software when one of the calibration buttons is pressed. 

 

ECG Calibration 

The ECG Calibration interface allows the user to generate a calibration signal for the ECG 
output, control the source of the signal, and enable or disable the notch filter. 

Current Value 

The numerical readout displays the current ECG signal measured by the MPVS 

Ultra.

 

ECG Scale 

The ECG Scale graphically displays the current ECG signal measured by the MPVS 

Ultra

 Detailed Operation

Summary of Contents for MPVS Ultra

Page 1: ...1 MPVS Ultra Signal Conditioning Hardware User Guide...

Page 2: ...dditional guidelines 29 V Troubleshooting System Maintenance and Specifications 31 Hardware 33 Cables 34 Technical Specifications 35 Technical Support 38 Recommended accessories 39 Warranty 42 I Intro...

Page 3: ...ge that is proportional to the electric field The system continuously measures this voltage across the receiving electrodes The measured voltage changes during the cardiac cycle as the left ventricula...

Page 4: ...the equipment so that cables can easily be disconnected especially the power cord in case of an emergency This system must be connected to an easily accessible wall outlet that remains accessible afte...

Page 5: ...th an ADInstruments PowerLab system should refer to the ADInstruments PowerLab setup section for specific instructions For users with other data acquisition systems packages of BNC to BNC cables are a...

Page 6: ...d transducer will be connected to the P2 input on the front panel Use the Control Interface to select the input for the second pressure channel ADInstruments PowerLab Setup As shown below the MPVS Ult...

Page 7: ...that the shield is connected to the ground pins indicated in the Theory of Operation section Users who build their own interface cables assume all responsibility for harm loss or damage related to th...

Page 8: ...d in the procedure Place the cuvette under the animal or in a bath of body temperature water to warm the plastic This will minimize temperature effects on the resistivity rho measurement 2 Prepare the...

Page 9: ...ata occlusion data stimulus reaction data and saline bolus data Smaller animals should have saline bolus maneuvers performed at the end of the study in case the saline induces detrimental effects on t...

Page 10: ...appear Click on Load to set the displayed resistivity as the value to be used in calibration and measurements 3 Prepare the animal 4 Catheterize the subject Monitor the data acquisition system output...

Page 11: ...ers with one or two pressure sensors When connecting to a three connector dual pressure P V transducer be sure to follow the labeling on the connectors to ensure that the pressure sensor inputs are no...

Page 12: ...log voltage signal of this measurement is provided on this connection but users typically will not use this signal in connection with blood sample temperature With proper calibration a user can choose...

Page 13: ...Segment capabilities a keycode will be supplied with the shipment For information about upgrading a MPVS Ultra Single Segment unit for use with Multi Segment PV catheters please contact Customer Servi...

Page 14: ...will relock the features after sixty seconds have passed with no configuration changes By default the catheter configuration used when the program is opened will be the same as the configuration when...

Page 15: ...Blood Resistivity This feature controls the resistivity used in Baan s equation for calculating the volume displayed on the gain and calibration controls within the Control Interface The values can al...

Page 16: ...tation electrodes 4 There must be at least two active sensing electrodes The green boxes below the catheter graphic label the location of the segments that are being measured The labels S1 S7 correspo...

Page 17: ...nductance Volume Range control are volume values or conductance values Create New Catheter Use this button to create a new entry in the Millar Catheter Selection table This is particularly useful if y...

Page 18: ...nterface Pressure 1 Pressure 2 The Pressure 1 and Pressure 2 scales graphically display the currently measured pressure from 25 mmHg to 200 mmHg This number is also numerically displayed The calculati...

Page 19: ...ressure as zero Pressure 2 Select The MPVS Ultra provides two amplifiers for use with a pressure transducer Pressure 1 is always set to the P V input connector on the MPVS Ultra front panel This will...

Page 20: ...ns are available at any given gain range Available buttons are beige others are gray The available selections are designed to span the expected segmental conductance inputs for typical animals ranging...

Page 21: ...To turn this filter on select On and to turn it off select Off ECG Input The ECG Input allows the user to choose the source of the ECG input signal The MPVS Ultra can record an internal ECG signal fro...

Page 22: ...number written on the cable Enter the K factor for your system The gain cannot be changed in this view Click OK then click on the new entry in the Millar Cuvette Selection table Delete Highlighted Cuv...

Page 23: ...urement F C 4 With as little delay as possible do steps 4 6 Place the cuvette on a flat surface and dry the well with a gauze or swab 5 In a heparinized syringe draw about 3cc to 5cc of blood Place th...

Page 24: ...cuvette should always be emptied and cleaned immediately after use to prevent blood from clotting within the cuvette Procedure for cleaning the cuvette 1 Properly dispose of the used blood sample 2 R...

Page 25: ...ventricular volume changes can be simplified in terms of Ohm s Law Ohm s Law V IR G 1 therefore R 1 x R G V I therefore G I x G V Volume G I x V ____________________ V voltage potential between E2 and...

Page 26: ...ion current through a selected primary excitation electrode E5 through E11 located at the proximal end of the measurement area and through primary excitation electrode E1 located at the distal end of...

Page 27: ...y is a material property whereas resistance and therefore conductance is a property of a sample or a structure When measuring the conductance of the blood in the ventricle the reading is based on the...

Page 28: ...will be reduced and the signal will be ideal for timing in PVAN Ultra calculations The input to the IECG signal is the electrodes that are presently in use for the primary excitation field This ensure...

Page 29: ...the inputs to the thermistor Do not connect to pins 1 2 3 or 4 since doing so may damage the resistivity measurement circuit Pin 7 may be used to ground the shield of the cable It is very important to...

Page 30: ...e and conductance Conductivity is the multiplicative inverse of resistivity Conductance is the multiplicative inverse of resistance G 1 R Conductance and conductivity relate to how well a structure or...

Page 31: ...ter tip Do not submerge the catheter s electrical connectors as doing so will damage the sensitive electronics housed inside The presoak helps prepare the pressure sensor diaphragm for the wet biologi...

Page 32: ...s to grip the Mikro Tip P V catheter slip some soft tubing over the tips of the metal instrument to cushion the interface between the instrument and the catheter body as shown in the photo Always be m...

Page 33: ...s disconnected from the monitoring equipment The Mikro Tip P V catheter should be thoroughly inspected under magnification after each use to determine its condition Carefully examine the catheter for...

Page 34: ...onnectors Contact Millar or your distributor for service Cables The cables can be wiped with isopropyl alcohol 70 Do not submerge the cables or cords When connecting and disconnecting the cables and c...

Page 35: ...nominal Input connector for system Five pin Redel or ODU Pressure Outputs Specification Value Sensitivity 1 V 100 mmHg nominal Accuracy Error Band 0 200mmHg 1 mmHg or 1 of reading whichever is greate...

Page 36: ...e 10 VDC Noise 75mVPP Input Connector 27 pin Alden Pulse Lok Pulse Lok is a registered trademark of Amphenol Alden Products Company Inc Output Connectors BNC connector Composite S1 S2 S3 S4 S5 S6 S7 V...

Page 37: ...resistance to power cord ground pin 7 ft cord 1 ohm Enclosure Specification Value Ingress protection IP 20 Dimensions 12 3 8 x 11 3 4 x 2 7 8 width x length x height 31 4cm x 29 7cm x 7 3cm width x l...

Page 38: ...r Off System power Technical Support Technical Support The Purchaser is entitled to free technical support for any Millar product Millar s technical support staff can provide help and advice concernin...

Page 39: ...were shipped with the system Use these part numbers when ordering 850 5105 North American cord with NEMA 5 15 plug 2m 6 7 long 850 5118European cord with CEE 7 VII plug 2 5m long 850 5117North America...

Page 40: ...dard BNC cables are required for connecting to the outputs of the MPVS Ultra BNC cable quality is important for ensuring clean signals so be sure to use coax cables with a braided copper shield Millar...

Page 41: ...M I P N 004 2163 Rev C 41 Connector part number PAGM07GLAC65GZ Strain relief part number GMA 1B 054 DG Rho Cuvette 910 1060Rho Cuvette Technical Specifications...

Page 42: ...other conditions cited in this Agreement General Limitations Millar products are produced to high standards and should perform substantially as described in the supplied documentation There is a limit...

Page 43: ...But Not Manufactured by Millar Millar supplied products of a third party manufacturer i e data acquisition systems amplifiers computers monitors and printers including associated cables probes accesso...

Page 44: ...ser via the following options Phone 832 667 7000 8 00AM 5 00PM Central Time M F Fax 713 714 8497 24 hours a day 7 days a week Email info millar com 24 hours a day 7 days a week Web millar com On site...

Reviews: