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Listed below are the seven different general procedures used to produce the routine
standard formulations in pharmaceutical preparation of ointments: EMULSION, EMULSION
+, NORMAL, SUSPENSION<2%, SUSPENSION>2% as well as GEL and SUPPOSITORIES. Due
to the rapid heat generation, powder mixtures should be processed only at very low speed.
In the following, these standard formulations will be defined and the recommended
procedure on weighing described. This will produce a code of practice for orientation. This
does not exclude other possible methods for optimization.
For mixtures with high liquid content, ensure that the ointment base on the UNGUATOR®
Jar Bottom is first carefully placed around the sealing lip. This enhances the leak tightness
of the UNGUATOR® Jar when it is filled. For UNGUATOR® Jars of 200 ml and up an active
ingredient proportion of less than 5 %, of the active ingredient can be filled alternating
with the foundation ointment over two or more levels to speed up vertical intermixture.
4.3
Preparing the mixing process
Together with the UNGUATOR® Jar Lid, the UNGUATOR® MB should be loosely screwed
onto the UNGUATOR® Jar body after the components of the formulation have been
weighed out. By pushing up the UNGUATOR® Jar bottom with your thumb or, for large
UNGUATOR® Jars, with the help of the UNGUATOR® Spindle or the AirDynamic® Pumpball
System, the air will escape between the UNGUATOR® Jar Lid and the UNGUATOR® Jar body.
Then the UNGUATOR® Mixing System should be tightly screwed down. This process is
called air diminuation.
Air diminution will prevent ointment exudation at the sealing zones of the UNGUATOR®
Jar through reduction of any overpressure that may have developed. The mixing result
is also optimized since there is no trapped air. We recommend, mainly in the case of
intermingling large quantities of powder, that air diminuation be repeated after 15 seconds
of the mixing process.
When pregrinding by pasting the solids with ointment base in the UNGUATOR® Jar,
we recommend positioning the movable UNGUATOR® Jar Bottom as far downward as
possible. This will guarantee that the large surface area of the inside wall of the
UNGUATOR® Jar also including the lid and bottom can be used for dispersion between
the friction surfaces of the UNGUATOR® MB and the inside surface area of the
UNGUATOR® Jar body. Consequently, no air diminuation need be carried out prior
pegrinding.
At this point of the mixing process, device-specific settings will need to be implemented
and the UNGUATOR® Mixing System connected to the UNGUATOR®.
