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cytiva Biacore 8K, Operating Instructions Manual

The Cytiva Biacore 8K is a cutting-edge instrument for analyzing biomolecular interactions. Ensure optimal performance by following the Operating Instructions Manual, available for free download from manualshive.com. The manual provides detailed guidance on operating and maintaining the Biacore 8K, maximizing the instrument's capabilities for precise results.

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Biacore 8K/8K

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Operating Instructions

Original instructions

cytiva.com

Summary of Contents for Biacore 8K

Page 1: ...Biacore 8K 8K Operating Instructions Original instructions cytiva com...

Page 2: ...nsport 50 4 3 Reinstallingthesoftware 52 4 4 Connections 53 5 Operation 55 5 1 Startingthesystem 58 5 2 Preparingforarun 61 5 3 Preparingandloadingsamples 64 5 4 Performingtherun 65 5 5 Closingdownthe...

Page 3: ...nsforNorth America 96 8 5 5 Regulatorystatements 97 8 5 6 Otherregulationsandstandards 98 8 6 DeclarationofHazardousSubstances DoHS 99 8 7 HealthandSafetyDeclarationForm 101 Index 103 TableofContents...

Page 4: ...safetynotices intendeduseofthe Biacore 8K 8K system andinformationconcerningassociated documentation Inthischapter Section Seepage 1 1 Aboutthismanual 5 1 2 Importantuserinformation 6 1 3 Associateddo...

Page 5: ...eSample hotel and sample compartment on page 29 butareotherwisecloselysimilar Thetwo systemstogetherarereferredtoasthe Biacore8K 8K system For Biacore8K systemswithProductNo 29146489 refertothe Operat...

Page 6: ...icalorin vitroprocedures Prerequisites Inordertooperatethe Biacore8K 8K systemsafelyandaccordingtotheintended purposethefollowingprerequisitesmustbemet YoumustreadandunderstandtheSafety Instructionsch...

Page 7: ...rdoussituationwhich ifnotavoided couldresultinminorormoderateinjury Itisimportantnotto proceeduntilallstatedconditionsaremetandclearlyunderstood NOTICE NOTICEindicatesinstructionsthatmustbefollowedtoa...

Page 8: ...UserManual Detailedinstructionsforusingthe BiacoreInsight EvaluationSoftwaretoevaluatetheresultsof experimentswiththe Biacore8K 8K instrument Softwarehelp On screenassistanceforusingthe Biacore8K 8K a...

Page 9: ...riment may be set up where different antibodies are attached to the sensor surface as ligands and challenged with antigen injected in solution as analyte In this case the object of the investigation i...

Page 10: ...bilization Thetermimmobilizationisusedtorefertopermanentattach mentofligandorcapturingmoleculetothesensorsurface normallybycovalentcoupling Ligand Theligandistheinteractionpartnerattachedtothesurface...

Page 11: ...edglassslidetowhichoneoftheinteractants the ligand isattached Sensorsurface Thesurfaceofthesensorchiponwhichtheinteractionbeing studiedtakesplace Sensorgram Aplotofresponseagainsttimeduringoneanalysis...

Page 12: ...ryprocedures andprovidesrecyclinginformation Important WARNING Beforeinstalling operatingormaintainingtheproduct all usersmustreadandunderstandtheentirecontentsofthis chaptertobecomeawareofthehazardsi...

Page 13: ...ning Generalprecautions WARNING Onlyproperlytrainedpersonnelmayoperateandmaintainthe product WARNING Donotoperatetheproductinanyotherwaythandescribedinthe userdocumentation WARNING Donotuseanyaccessor...

Page 14: ...Liquidsmarkedasflammablemustnotbeusedasrunningbufferor pumpedreagents Anybufferorreagentcontainingflammable substancesmustbeplacedinproperlycoveredpositionsinmicro plates WARNING Explosionhazard Toavo...

Page 15: ...regulations CAUTION Pinchrisk Takecarethatfingersarenottrappedbymovingparts ontheinstrument CAUTION Accidentalbreakageofglassbottlesmayleavesharpfragments andsplintersthatcancausecutsandabrasions Inst...

Page 16: ...tfallingobjects CAUTION Makesurethathandsorfingersarenottrappedundertheinstru mentwhentheinstrumentisliftedormoved CAUTION Lockthewheelsonthetrolleybeforeusingtheinstrument Powersupply WARNING Protect...

Page 17: ...rswithcapacity5Lor moremaybeheavy Takeappropriateprecautionswhenlifting CAUTION Donotoverloadthepull outshelfonthetrolley Themaximumload capacityismarkedontheshelf CAUTION Donottouchthepumpswhiletheya...

Page 18: ...cumentation mustbecarriedoutby personnelauthorizedby Cytiva Donotopenanycoversorreplace anypartsunlessspecificallystatedintheuserdocumentation WARNING Theproductcontainsmainsvoltageofupto240VAC Discon...

Page 19: ...onotrunShutdownoranyothermaintenance proceduresthatuse20 ethanolatsamplecompartmenttemper aturesabove25 C Decommissioning WARNING Decontaminatetheequipmentbeforedecommissioningtoensure thathazardousre...

Page 20: ...uthorizedrepresen tativeofthemanufacturerforinformationconcerningthe decommissioningofequipment Thissymbolindicatesthattheproductcontainshazardousmate rialsinexcessofthelimitsestablishedbytheChinesest...

Page 21: ...29 CFR Part1910 7 CAN ICES 1 NMB 1 CANICES 1 NMB 1inidicatesthatthisproductcomplieswiththe CanadianstandardICES 001concerningelectromagnetic compatibility Safetylabelsandothersymbols Thefollowinglabel...

Page 22: ...otusetheacuteemergencystopprocedureunlessthereisa riskofinjury damageorlossofvaluablematerial Alloperations includingbufferflowanddatacollectionarestoppedimmediately Controlledemergencystop Followthes...

Page 23: ...trationbelowshowsthe Biacore8K instrument thepowerswitchon the Biacore8K instrumentislocatedinthecorrespondingposition NOTICE Donotleavethesysteminanemergencystopcondition Always followtherestartproce...

Page 24: ...henstops Datacollecteduptoandincludingthelastcyclecompleted beforethepowerfailureissavedintheresults Recoveringsampleswhenthepower hasfailed Followthestepsbelowifyouneedtorecovermicroplateswithsamples...

Page 25: ...t Function 1 Samplehotelreleasewire Biacore8K instrument Griptheright handedgeofthehoteldoorand pullhardtoforcethemagneticlockonthedoor NOTICE Powertothehotelandsamplecompartmentwillbecut andanytraymo...

Page 26: ...ly 2 Thesystemwillattempttoreturnanysampletrayinthesamplecompart menttothesamplehotel Ifthisdoesnotsucceed contact Cytiva service 3 Ifyouneedtocleantheliquidhandlingsystem ejectthesensorchipand insert...

Page 27: ...ore8K 8K system Inthischapter Section Seepage 3 1 Instrumentcomponents 28 3 2 Flowsystem 33 3 3 Temperaturecontrol 38 3 4 Samplehandling 39 3 5 Signaldetectionandprocessing 41 3 6 Systemsoftware 42 3...

Page 28: ...2 Samplecompartmentwithwindow 3 Sensorchipport 4 Tubinginletpanel 5 Railsforaccessoryholders 6 Wastetube 7 Fittingsforliftingrods 8 Adjustablefeet 9 Driptray underinstrument 10 Peristalticpumps behind...

Page 29: ...t 9 Driptray underinstrument 10 Hoteldoorreleasebutton 11 Peristalticpumps behindhingedcover Samplehotelandsample compartment Thesamplehotelistheareawheretrayscarryingsamplesandreagentscanbe inserteda...

Page 30: ...rument the samplehotelhasonlytwotraypositions 2 1 3 4 6 5 Part Function 1 Samplehotel 2 Sampletraypositions 2in Biacore8K 6in Biacore8K 3 Sampleloadingcarriage 4 Liquidsupplyblock 5 Eightparallelinjec...

Page 31: ...henpushgently onthedooruntilitclicksinto place Closethedoorgentlyuntilthe magneticlockengages NOTICE Donotleavethesamplehoteldooropenunnecessarily sincethis mayaffecttemperatureregulationofthesampleco...

Page 32: ...catedatthelowerrearoftheinstrumentonthe left handside Theillustrationbelowshowsthe Biacore8K instrument Electricalconnectionsarein theequivalentpositiononthe Biacore8K instrument Part Function 1 USBco...

Page 33: ...ubinginletpanel Liquidsarepumpedintotheflowsystemthroughinlettubesontheright handsideof theinstrument ThetubeportsarelabeledBUFFER WATER andREAGENT usedfor runningbuffer distilledwater andlarge volume...

Page 34: ...heinstrument behindahinged panel shownwiththepanelremovedintheillustrationbelow Openthepanelby pullingoutwardsonthetopedge toaccessthepumpsandreleasethepumpclamps whentheinstrumentisshutdown Theillust...

Page 35: ...wayfromthepumpbody Dothisforbothclampsoneachpump Closethe pumpclamps Pushtheclamptowardsthepumpbodyuntilitclicksintoplace Makesuretheclampstaysalignedwiththepumpbodyonboth sidesastheclampisclosed Doth...

Page 36: ...Integratedmicrofluidiccartridge consistsofaseriesofmicro channelsand membranevalvesencasedinaplastichousing andservestocontroldeliveryofliquid fromtheliquidsupplyblocktothesensorchipsurface Grooveson...

Page 37: ...ed Anadditionaldrainagetubecollectscondensationandanyspillageorleakagefromthe samplecompartment anddrainstoadriptrayunderneaththeinstrument Condensed waterthatdrainsfromthesamplecompartmentwillnormall...

Page 38: ...mperature anddoesnotaffecttheabilitytostartarun Ifthesamplecompartmenttemperaturediffersfromtheflowcelltemperature injectedsolutionsequilibratetotheflowcelltemperatureduringtransferfromthe microplatet...

Page 39: ...e8K system seetheBiacore 8K 8K User Manualfor detailsofhowrunsaresetup Microplatecovers Microplatesshouldbecovereddirectlyafterpreparationtopreventevaporation The coverispenetratedbytheinjectionneedle...

Page 40: ...ner shapes on microplates are not standardized and the angled corner is not always at position A1 as shown in this illustration Orient the micro plate by well position and not by corner shape Samplein...

Page 41: ...bout150nm tothesensorsurfaceontheoppositesideofthegoldfilm so thatchangesintheSPRanglecanbeusedtomonitorthechangesinconcentrationat thesensorsurfaceasinteractionproceeds Thelightusedtogeneratethesigna...

Page 42: ...ntswitched off tocreateanalysismethodsandtoopensavedresults EvaluationSoftware BiacoreInsight EvaluationSoftwareisastand alonesoftwareforevaluationofresults obtainedfrom Biacore8K 8K andsomeotherBiaco...

Page 43: ...ING Heavypackage Thedeliveredinstrumentpackageisheavy Use suitableliftingandmovingequipmenttohandlethepackage WARNING Heavyobject Usefourormoreproperlytrainedpersonsorsuit ableliftingequipmentwhenmovi...

Page 44: ...hsteeltoecapswhenmovingtheinstru menttoprotectagainstfallingobjects CAUTION Makesurethathandsorfingersarenottrappedundertheinstru mentwhentheinstrumentisliftedormoved 4 Installation 44 Biacore8K 8K Op...

Page 45: ...ed Donotinstallthe instrumentonafixedlaboratorybench Accesstotherearoftheinstrumentisrequired forservicepurposesandforliftingtheinstrument seeLifting and moving on page 51 Thedimensionsoftheinstrument...

Page 46: ...stallationsitemustcomplywiththefollowingspecifications Parameter Specification Allowedlocation Indooruseonly Ambienttemperature Maximumchangerate 18 Cto33 C fullperformance 15 Cto35 C operational 0 25...

Page 47: ...directionontheinstrumentareshownintheillustration below Electricalpowerrequirements WARNING Protectiveground Theproductmustalwaysbeconnectedtoa groundedpoweroutlet WARNING Useonlymainscablessuppliedor...

Page 48: ...quirementslistedbelow CPUwithatleasttwocores Atleast8GBinternalmemory 4GBfree Atleast40GBfreeharddiskspace Screenresolutionatleast1600 900 thegraphicaluserinterfaceisoptimizedfor 1920 1080 OneUSB2port...

Page 49: ...maybeinstalledautomaticallytogetherwiththesoft ware however anetworkdatabaseisrecommendedforregularuseofthesystem A networkdatabaseisrequiredifdatafromseveralinstrumentsistobestoredinthe samedatabase...

Page 50: ...roductis installedmusthavealoadcapacityofatleast200kg CAUTION Wearprotectiveshoeswithsteeltoecapswhenmovingtheinstru menttoprotectagainstfallingobjects CAUTION Makesurethathandsorfingersarenottrappedu...

Page 51: ...owtheinstructionsbelowiftheinstrumentneedstobeliftedfromthetrolley Step Action 1 Insertthetwoliftingrodsintothefittingsundertheinstrument Therods shouldextendsufficientlyinfrontofandbehindtheinstrumen...

Page 52: ...efromcytiva com eDelivery Youwillneedtoprovide youraccountcredentials Contact Cytiva customersupportifyourequire assistance 2 Installthesoftwareaccordingtotheinstructionsonthedownloadportal 3 Iftherei...

Page 53: ...ePCandperipheralequipmentaccordingtotherespectiveinstruc tionmanuals Connecttheinstrumenttothe computer NOTICE AnycomputerusedwiththeequipmentshallcomplywithIEC 60950requirementsandbeinstalledanduseda...

Page 54: ...perform thestepsintheorderlistedbelow Thiswillensurethatthecorrectdriversareinstalled onthecontrollingcomputer Step Action 1 Makesurethatthesoftwareisinstalledonthecomputerandthatthe computerisswitch...

Page 55: ...are 68 Precautions WARNING Alwayswearappropriateprotectiveclothingandequipmentduring operationandmaintenanceoftheproduct Userequiredsafety equipmentwhenhandlinghazardoussubstances WARNING Afumehoodors...

Page 56: ...apartduring operation CAUTION Ensurethatallfluidictubesaresecuredandproperlyconnectedor sealedatbothendsbefore duringandafteroperation CAUTION Wastetubesandcontainersmustbesecuredandsealedto preventac...

Page 57: ...nedtobeusedwithliquidsupplybottlesonthe right handsideoftheinstrumentandthecontrollingcomputeron theleft Donotplacethecomputerontherightwherethereisarisk ofspillage 5 Operation Biacore8K 8K OperatingI...

Page 58: ...ssingtheclampstowardsthepumpbodyuntilthey clickintoplace seePeristaltic pumps on page 34 Makesuretheclamps stayflushwiththepumpbodyonbothsidesastheclampisclosed 2 Switchonthepowertotheinstrument seeEl...

Page 59: ...licktheEditicon besidetheDatabasenametochangetheselected database Contactyoursystemadministratorifyouareuncertain 7 Enteryouraccountcredentials YourWindowsusernameandpasswordare validascredentialsfor...

Page 60: ...e theinstrumentstatuspanelatthebottomofthe screenshowsRunningstandbyflow nofurtheractionisneeded Standbymodewill bestoppedautomaticallywhenanewinstrumentactivityisstarted 5 Operation 5 1 Startingthesy...

Page 61: ...ved from the queue quickly However temperature equilibration normally takes a longer time Setuptheliquidsupply Followtheinstructionsbelowtoproviderunningbuffer distilledwater optionallarge volumereage...

Page 62: ...hipwillbedockedintheinstrument Normally youwillneedtoreplacethissensorchipwithoneappropriateforyourrun Followthestepsbelowtochangethesensorchip Followthesamestepsbutomit step2iftheinstrumenthasbeenres...

Page 63: ...thoddefinition 3 GototheVariablesandpositioningtab Enterormodifythevariable detailsasrequiredincludingsampleinformation microplatetypesandposi tionassignments 4 Optional GototheCycleoverviewtabandchec...

Page 64: ...roplatesasrecommended seeMicroplate covers on page 39 topreventevaporationfromthesamplesduringanalysis Note Microplate foils and septa may cover the well position identifiers on the microplates You ma...

Page 65: ...el door on page 31 6 Placethesampletray s onthecorrectshelfinthesamplehotelasassigned inthesoftware 7 Closethehoteldoor MakesurethatthestatusisshownasClosedinthe software 8 ClickReadytostart 9 Navigat...

Page 66: ...eintendedstandbyperiod Emptythewastebottle Cleanthedriptrayifnecessary Standbymode Alwaysleavethesysteminstandbymodeunlesstheinstrumentistobeshutdown Standbymodewillusethecurrentbuffertube Tip The cur...

Page 67: ...ption mL 24h Passesoversensorsurface BUFFER 250 Yes WATER1 150 No REAGENT1 25 No 1 PlaceboththeREAGENTandWATERtubinginthewaterbottle 5 Operation 5 4 Performingtherun Biacore8K 8K OperatingInstructions...

Page 68: ...byandclosethesoftware recom mended 1 2 Closethesoftware Standbyrunning Closethesoftware Activityqueuenotempty butnoactivitystarted Closethesoftware Activitiesinthequeuewillbe discarded Activityrunning...

Page 69: ...dures WARNING Explosionrisk DonotrunShutdownoranyothermaintenance proceduresthatuse20 ethanolatsamplecompartmenttemper aturesabove25 C WARNING Alwayswearappropriateprotectiveclothingandequipmentduring...

Page 70: ...bingmaybetoxicorflammableor maycausechemicalburnsorirritationtoskinandeyes Take appropriateprecautionsintheeventofbottlebreakage accidental spillageandinsecurefittingoftubingstobottles WARNING Ifthein...

Page 71: ...opbanneroftheControlSoftwarewhensched uledmaintenanceisdue Clickthenotificationsymbolforinformationincluding optionstoaddthemaintenanceoperationtotheactivityqueueorignorethereminder Requiredmaterials...

Page 72: ...ingtheflow system RuntheDesorbtoolfromtheInstrumentcontrolworkspaceandfollowtheinstruc tionsonthescreentocleantheflowsystem Youwillneedtworowsofwellpositionsin a96 deepwellmicroplateforBIAdesorb1andBI...

Page 73: ...Service Health and Safety Declaration FormortheHealth and Safety Declaration Form for Product Return or Servicing dependingonwhethertheinstrumentisgoingtobeservicedonsiteorreturnedfor service respecti...

Page 74: ...onsbelowtoreplacethemainsfuses Step Action 1 Turnoffthepowertothe Biacore8K 8K instrument 2 Disconnectthemainscordfromthemainspowerinlet 3 Insertasmallflat bladedscrewdriverunderthetabonthefusedrawer...

Page 75: ...utsidesurfacesoftheinstrumentusing asoftclothandwateroramilddetergent Releasetheperistalticpumpclampsbefore storage seePeristaltic pumps on page 34 Maintainnormalconditionsoftemperatureandhumiditywhil...

Page 76: ...ng Aboutthischapter Thischapterdescribestroubleshootingprocedures Inthischapter Section Seepage 7 1 Troubleshootingtools 77 7 2 Instrumentproblems 79 7 Troubleshooting 76 Biacore8K 8K OperatingInstruc...

Page 77: ...ndsamplecompartmenttemperatureto25 C 2 FillthebufferbottlewithHBS EP buffer PlacetheBUFFERAandBUFFERCtubesinthebufferbottleandthe BUFFERBandBUFFERDtubesindeionizedwater 3 DockanunusedSeriesSSensorChip...

Page 78: ...ck Airinflowsystemduetoleakageor blockedchannel Contact Cytiva service Failedleakage Particlesonthesensorchip Changethe chipandrerunSystemcheck IFCorpneumaticsystemfailure Contact Cytiva service Mixin...

Page 79: ...samplecompart ment Thisisnormal Waituntilthetray movementiscomplete Powerfailure Thedoorshouldoperatenormally whenthepowerisrestored SeeRecovering samples when the power has failed on page 24ifyou nee...

Page 80: ...foreor afterinjection Somedisturbances frominjectionprepara tionandwashare normal Baseline disturbancesaremore noticeableathigher flowcelltemperatures andhigherflowrates Contact Cytiva serviceifthe di...

Page 81: ...also affectadjacentchan nels Theriskishighestat elevatedflowcell temperaturesandlow samplecompartment temperatures and whentheinjectiontime isalargepartofthe totalcycletime Makesurethatallmicroplate w...

Page 82: ...ignal spikesduring injectionand dissociation phase IFCmalfunction Contact Cytiva service Sensorgramoscil lationduringinjec tions Incompleteneedle wash Checkthatallperistalticpump clampsarecorrectlyclo...

Page 83: ...esolutions Leakage Contact Cytiva service Injectionfromempty microplatewell Injec tionofaircandelay subsequentinjections inthesamechannel Makesureallusedmicroplate positionscontainsufficientliquid 7 T...

Page 84: ...Section Seepage 8 1 Systemspecifications 85 8 2 Orderinginformation 87 8 3 Chemicalresistanceofwettedparts 88 8 4 Recyclinginformation 90 8 5 Regulatoryinformation 91 8 6 DeclarationofHazardousSubsta...

Page 85: ...wersupply 100to240V 50 60Hz Maximum 10 fluctuationfromthenominal voltage Maximumpowerconsumption excludingcomputer Biacore8K instrument Biacore8K instrument 350VA 550VA Fuserating 2 T6 3AH250V Overvol...

Page 86: ...1 C Maximumhumidity decreaseslinearlyto67 RHat35 C Relativehumidity transportation 5 to95 Atmosphericpressure transportation 0 85to1 15bar Altitude operation Upto2000m Pollutiondegreeoftheintendedenvi...

Page 87: ...tion Systemandrelatedproducts Orderinginformationforthe Biacore8K 8K systemandrelatedproductsmaybe foundon cytiva com biacore 8 Referenceinformation 8 2 Orderinginformation Biacore8K 8K OperatingInstr...

Page 88: ...forrecom mendationsconcerningsubstancesnotlistedhere Chemicalresistance Concentratedorganicsolventsaswellaslong termexposuretoextremesofpH 3 and 11 shouldbeavoided Forsolutionswithshort termcompatibil...

Page 89: ...Solution Concentration Compatibility Urea 8M Shortterm 8 Referenceinformation 8 3 Chemicalresistanceofwettedparts Biacore8K 8K OperatingInstructions29286967AC 89...

Page 90: ...eseparatedand recycledaccordingtonationalandlocalenvironmentalregulations Recyclingofhazardoussubstances Theproductcontainshazardoussubstances Detailedinformationisavailablefrom your Cytiva representa...

Page 91: ...ion Section Seepage 8 5 1 Contactinformation 92 8 5 2 EuropeanUnionandEuropeanEconomicArea 93 8 5 3 EurasianEconomicUnion 94 8 5 4 RegulationsforNorthAmerica 96 8 5 5 Regulatorystatements 97 8 5 6 Oth...

Page 92: ...Manufacturinginformation Thetablebelowsummarizestherequiredmanufacturinginformation Requirement Information Nameandaddressofmanufacturer CytivaSwedenAB Bj rkgatan30 SE75184Uppsala Sweden Telephonenum...

Page 93: ...fnotincludedwiththeproduct acopyoftheEUDeclarationofConformityisavailable onrequest CEmarking TheCEmarkingandthecorrespondingEUDeclarationofConformityisvalidforthe instrumentwhenitis usedaccordingtoth...

Page 94: ...ingtableprovidessummaryinformationaboutthemanufacturerand importer inaccordancewiththerequirementsoftheTechnicalRegulationsofthe CustomsUnionand or theEurasianEconomicUnion Requirement Information Nam...

Page 95: ...123112 10 12 III 6 74957396931 74957396932 rucis cytiva com 8 Referenceinformation 8 5 Regulatoryinformation 8 5 3 EurasianEconomicUnion Biacore8K 8K OperatingInstructions29286967AC 95...

Page 96: ...e the equip ment ThisequipmenthasbeentestedandfoundtocomplywiththelimitsforaClassAdigital device pursuanttopart15oftheFCCRules Theselimitsaredesignedtoprovide reasonableprotectionagainstharmfulinterfe...

Page 97: ...radioreceptionin suchenvironments SouthKorea RegulatoryinformationtocomplywiththeKoreantechnicalregulations NOTICE ClassAequipment equipmentforbusinessuse Thisequipmenthasbeenevaluatedforitssuitabilit...

Page 98: ...meetthesafetyrequire mentsofEN IEC61010 1 orotherrelevantnationalsafetyregulationsandstandards WithinEU connectedequipmentmustbeCEmarked NOTICE AnycomputerusedwiththeequipmentshallcomplywithEN IEC 609...

Page 99: ...roductswillnotleakormutateundernormal operatingconditionssothattheuseofsuchelectricalandelectronicproductswillnotresultin anysevereenvironmentalpollution anybodilyinjuryordamagetoanyassets Theunitofth...

Page 100: ...sthatthishazardoussubstancecontainedinallofthehomogeneous materialsforthispartisbelowthelimitrequirementinGB T26572 X Indicatesthatthishazardoussubstancecontainedinatleastoneofthe homogeneousmaterials...

Page 101: ...r instrument service repair or installation In some cases this may require customer to move equipment from normal operating location prior to Cytiva arrival Consumables such as columns or gels have be...

Page 102: ...must be decontaminatedprior to service return Provide a telephone number where Cytiva can contact you for additional information concerning the system equipment Telephone No Liquid and or gas in equi...

Page 103: ...ctingtheinstrument 72 Dockchip 62 Driptray 28 29 37 E Electricalconnectionpanel 32 Electricalrequirements 48 Emergencyprocedures 22 acutestop 22 controlledstop 22 Emergencystop 22 Environmentalconditi...

Page 104: ...s 90 Regulatorycompliance 98 connectedequipment 98 Regulatoryinformation 91 Reinstallingthesoftware 52 Reminders 42 Replacingfuses 74 Resourcesontheweb 8 Restartafterpowerfailure 26 S Safety 13 precau...

Page 105: ...ansport 51 Troubleshootingproblems 79 Tubinginletpanel 33 Typographicalconventions 5 U Undockchip 62 Unpacking 50 Userdocumentation 8 Usermaintenance 71 schedule 71 V Ventilation 46 W Wastetube 28 29...

Page 106: ...ners 2020 Cytiva Anyuseof Biacore8K 8K software issubjectto Cytiva StandardSoftwareEnd UserLicenseAgreementforLifeSciencesSoftware Products AcopyofthisStandardSoftwareEnd UserLicenseAgreementisavailab...

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