Coaguchek INRange, User Manual, Page: 14 / 296

14
Test principle
The CoaguChek XS PT Test PST test strip
contains a lyophilized reagent (reagent in
dried form). The reactive components of
this reagent consist of thromboplastin and a
peptide substrate. When a sample is applied,
thromboplastin activates coagulation, which
leads to the formation of thrombin. At the
same time, the meter starts to measure the
time. The enzyme thrombin cleaves the pep-
tide substrate, generating an electrochemical
signal. Depending on the time elapsed when
it first appears, this signal is then converted
by means of an algorithm into customary
coagulation units (INR, %Quick, seconds) and
the result is displayed.
Introduction
CoaguChek INRange User’s Manual