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A Safety Advisories

September, 2019, 715003738IVD Rev. C

Electrical and handling symbols

Electrical symbols

The following electrical symbols and their associated statements can appear

in instrument manuals and on an instrument’s front or rear panels.

Electrical power on

Electrical power off

Standby

Direct current

Alternating current (single phase)

Protective earth terminal

Frame or chassis ground

Fuse

Содержание ACQUITY UPLC I-Class IVD

Страница 2: ...ii Rev C 715003738IVD...

Страница 3: ...T S POSSIBLE are trademarks of Waters Corporation PEEK is a trademark of Victrex Corporation Phillips is a trademark of Phillips Screw Company TORX is a trademark of Textron Corporation Other register...

Страница 4: ...ces you work with Always follow good laboratory practice and consult your organization s safety representative for guidance Telephone and fax From the USA or Canada phone 800 252 HPLC 800 252 4752 or...

Страница 5: ...ICES 001 Cet appareil num rique de la classe A est conforme la norme NMB 001 Electrical power safety notice Do not position the instrument so that it is difficult to operate the disconnecting device W...

Страница 6: ...mpaired Safety advisories Consult Appendix A for a comprehensive list of warning and caution advisories Operating this device When operating this device follow standard quality control QC procedures a...

Страница 7: ...ithin the product are likely to be discarded or degrade into the environment Consult instructions for use Alternating current Electrical and electronic equipment with this symbol may contain hazardous...

Страница 8: ...ructions Quality control Routinely run three QC samples that represent subnormal normal and above normal levels of a compound If trays are the same or very similar vary the location of the QC samples...

Страница 9: ...Group 1 Class B This classification has been assigned in accordance with IEC CISPR 11 Industrial Scientific and Medical ISM instruments requirements Group 1 products apply to intentionally generated...

Страница 10: ...anufacturing information Australian sponsor information Waters Corporation 34 Maple Street Milford MA 01757 USA Australian Sponsor Emergo Australia Level 20 Tower II Darling Park 201 Sussex Street Syd...

Страница 11: ...emissions notice v Electrical power safety notice v Safety hazard symbol notice vi Equipment misuse notice vi Safety advisories vi Operating this device vi Applicable symbols vi Audience and purpose v...

Страница 12: ...quired tools 38 Installing the optional in line filter 41 Required materials 42 Required tools 42 Installing the column 44 Required materials 44 Required tool 44 3 Using the column heater 49 Resolving...

Страница 13: ...ls 77 Required tools 77 Cleaning the instrument s exterior 79 A Safety Advisories 81 Warning symbols 81 Specific warnings 83 Burst warning 83 Biologically hazardous materials warning 83 Biologically h...

Страница 14: ...xiv September 2019 715003738IVD Rev C Electrical specifications 96 Performance specifications 97 Wetted materials of construction 98...

Страница 15: ...such as those caused by air conditioning or heating affect the performance of the column preheater also known as a stablilizer Ensure that the temperature limits you set are in accordance with your an...

Страница 16: ...ses an electric heating element to directly heat the column inlet tubing The rapid heating low volume design reduces gradient delay and extra column bandspreading It ensures that high flow rate separa...

Страница 17: ...ss spectrometer you can mount the assembly on an external bracket on the right hand side of the chassis In line filter Protects the analytical column against contamination by trapping impurities befor...

Страница 18: ...e solvent enters the column Originally used in the ACQUITY UPLC system the column stabilizer can be useful when you transfer methods from that system Drip tray Captures any leakage from the column or...

Страница 19: ...itting hole before tightening the compression screw For easier accessibility use long compression screws to attach tubes to the injector and vent valve Contents Topic Page Installation recommendations...

Страница 20: ...ve preheater s reusable compression fitting in place and rotate the column or in line filter onto the fitting When tightening system fittings consult the following table Installation recommendations f...

Страница 21: ...plus 3 4 turn using wrench Reinstalled Stainless steel gold plated fitting with long flats and 2 piece stainless steel ferrule Finger tight plus up to 1 6 turn using wrench Installation recommendatio...

Страница 22: ...ainless steel cap nut from the gold fitting 2 Finger tighten the gold fitting with the ferrule into the column Requirement If you are reinstalling the fitting replace the PEEK ferrule 3 Rotate the col...

Страница 23: ...en end wrench 4 mm open end wrench 3 mm hex wrench Phillips screwdriver Small flat screwdriver T20 TORX driver Process for installing the MS bracket Task See Remove the column heater from the device c...

Страница 24: ...burn injuries set the column temperature to Off and then allow the column compartment and its components to cool for 60 minutes before touching them Monitor the column compartment s internal temperatu...

Страница 25: ...remove the column To install the MS bracket on the column heater chassis 1 Using a small screwdriver gently pry out the active preheater retainer and remove it from the column compartment 2 Slide the...

Страница 26: ...hand side of the column heater just behind the eCord receptacle 6 Remove the column heater chassis by gently pulling it toward you with your left hand while releasing the lock with your right hand 7...

Страница 27: ...t secures the column heater s rear enclosure to the sample manager chassis c Remove the column heater s rear enclosure from the sample manager s chassis d Secure the retainer bracket supplied in the c...

Страница 28: ...n the chassis f Install the Phillips screw that secures the column heater s rear enclosure to the chassis g Replace any other instruments and the solvent tray above the column heater s rear enclosure...

Страница 29: ...n the slot as you guide the tab into the cutout If the cable slips out of the slot it can prevent the bracket from seating fully into the chassis d Tighten the TORX screw in the tab e Tighten the 3 mm...

Страница 30: ...TORX screws that secure the hinge to the MS bracket b Using two TORX screws attach the hinge assembly on the column heater housing to the height adjustment bracket c Swing the column heater housing a...

Страница 31: ...of the MS bracket drip tray and slide the leak sensor into place b Route the leak sensor cable through the slot in the column heater housing 3 Secure the 25 pin cable a Insert the 25 pin cable into t...

Страница 32: ...the left hand side of the column heater into the slot on the left hand side of the housing b Hold the left hand side of the column heater into the slot and guide the eCord tab on the right hand side...

Страница 33: ...ocket 6 If you installed the optional leak sensor plug the connector into the receptacle located behind the column heater 7 Swing the column heater into the operating position 8 Push the drain tubing...

Страница 34: ...hand side of the column compartment until it snaps into place b Install the active preheater assembly in the retainer To install the column in the column tray and connect inlet and outlet tubing 1 Sn...

Страница 35: ...t the column inlet to the active preheater by holding the active preheater s reusable compression fitting in place rotating the column onto the fitting until it is snug and then tightening an addition...

Страница 36: ...element through the thermal gasket to the column inlet tubing The looped tubing path reduces dispersion while ensuring maximum surface area contact between the tubing and the column tray maximizing h...

Страница 37: ...ass IVD system Requirement You must remove the active preheater assembly before installing the column stabilizer assembly For instructions on how to replace the column stabilizer assembly see page 73...

Страница 38: ...ng for connecting the column to the MS flow cell Three Phillips screws one is a spare Three thermal gaskets two are spares Required tools Needle nose pliers Phillips screwdriver To install the optiona...

Страница 39: ...ose pliers gently compress the top and bottom of the active preheater retainer and pull it out of the column compartment 6 Remove the clear protective backing from the thermal gasket and with the ther...

Страница 40: ...ly press the column stabilizer assembly into the thermal gasket ensuring that the thermal gasket uniformly envelops the sides of the column stabilizer and does not bunch beneath it Column stabilizer a...

Страница 41: ...e the tubing behind the sample manager door hinge 12 Remove the O ring retainer from the inlet end of the column stabilizer inlet tubing and then connect the inlet tubing to injector port 6 of the sam...

Страница 42: ...re that the ferrule is approximately 3 mm from the end of the outlet tubing and that the collet is touching the back of the ferrule Warning To avoid burn injuries set the column temperature to Off and...

Страница 43: ...r inlet until it stops Installing the in line filter 3 Holding the reusable fitting in place rotate the in line filter unit onto the fitting until it is snug 4 Finger tighten the fitting until it is s...

Страница 44: ...h the outlet end of the column in line filter unit into the column inlet until it stops Warning To avoid burn injuries set the column temperature to Off and then allow the column compartment and its c...

Страница 45: ...e high temperature outlet fitting into the column outlet until it is finger tight 3 Using a 5 16 inch wrench to hold the column steady use the high temperature outlet fitting wrench to give the outlet...

Страница 46: ...es the type of MS and flow cell in your system 3 Attach the 0 004 inch or 0 0025 inch ID inlet tubing included with the flow cell or the stabilizer kit to the column outlet 4 Snap the column support c...

Страница 47: ...er before you connect or disconnect the external communication cable between the sample manager and the column heater Caution To avoid damage to the components power off the sample manager before you...

Страница 48: ...2 Preparing the column heater 48 September 2019 715003738IVD Rev C...

Страница 49: ...nition temperatures are below 150 C Warning To avoid breathing harmful fumes or vapors when using hazardous solvents run the system in a hooded environment that provides a sufficient air exchange rate...

Страница 50: ...pen the column heater s door Otherwise see the Resolving leak sensor errors section in the Sample Manager Operator s Overview and Maintenance Information document 3 Locate the source of the leak and r...

Страница 51: ...lumn outlet PEEK tubing from the detector inlet 6 Remove any solvent tubing routed behind the column heater door 7 Power off the sample manager and detach the leak sensor connector from the front of t...

Страница 52: ...the leak sensor from its reservoir grasping it by its serrations and pull upward on it tilting it to the left hand side Tip If you cannot easily manipulate the leak sensor after removing it from its...

Страница 53: ...C 53 11 Use a nonabrasive lint free wipe to dry the leak sensor prism 12 Roll up a nonabrasive lint free wipe and use it to absorb the liquid from the leak sensor reservoir and its surrounding area T...

Страница 54: ...d from the corners of the leak sensor reservoir and its surrounding area 14 Align the leak sensor s T bar with the slot in the side of the leak sensor reservoir and slide the leak sensor into place Co...

Страница 55: ...3738IVD Rev C 55 15 If you detached the connector from the front of the instrument reattach it and power on the sample manager 16 In the ACQUITY UPLC Console select Sample Manager FTN from the system...

Страница 56: ...3 Using the column heater 56 September 2019 715003738IVD Rev C...

Страница 57: ...Y UPLC Console online Help Under normal operating conditions the column compartments do not require any maintenance If residue from solvent leaks accumulates in the column compartment remove the colum...

Страница 58: ...ce based on system usage see page 63 Recommended routine maintenance schedule Maintenance procedure Frequency For information Replace the leak sensor on the column heater As needed For example when th...

Страница 59: ...tive preheater assembly connections and or replace the ferrules Split peaks Reseat the active preheater assembly connections and or replace the ferrules See page 70 Replace the column stabilizer assem...

Страница 60: ...er unit As needed The typical failure modes are as follows High back pressure The column in line causes a high pressure shutdown In this case disconnect the in line filter If the system exhibits press...

Страница 61: ...rs Quality Parts Visit www waters com wqp for information about Waters Quality Parts including how to order them Warning To avoid the harmful effects of personal contact with solvents including inhala...

Страница 62: ...version For complete information on reporting shipping damages and submitting claims see Waters Licenses Warranties and Support Services documentation Locating system serial numbers The serial number...

Страница 63: ...nance warnings that alert you when a component reaches the designated threshold limit By setting threshold limits and monitoring these usage counters regularly you can minimize unexpected failures and...

Страница 64: ...ample manager 3 Open the sample manager door gently pulling its right hand edge toward you 4 Press down on the tab to detach the leak sensor connector from the front of the instrument 5 Disconnect the...

Страница 65: ...ev C 65 7 Remove the TORX screw from the right hand side of the column heater just behind the eCord receptacle 8 Remove the column heater chassis by gently pulling it toward you with your left hand wh...

Страница 66: ...Remove the leak sensor from its reservoir grasping it by its serrations and pull upward on it tilting it to the left To install a new leak sensor 1 Unpack the new leak sensor Caution To avoid damaging...

Страница 67: ...leak sensor reservoir and slide the leak sensor into place 3 Plug the leak sensor connector into the front of the instrument 4 Insert the tab on the left hand side of the column heater into the slot...

Страница 68: ...ocated behind the eCord receptacle 7 Connect the column inlet active preheater or column stabilizer tubing to injector port 6 of the sample manager 8 Connect the column outlet PEEK tubing to the MS in...

Страница 69: ...following a Remove the active preheater assembly from the retainer b While holding the column disconnect the column outlet tubing Warning To prevent burn injuries set the column temperature to Off and...

Страница 70: ...ollet separator over the collet on the column stabilizer tubing and gently move it back and forth to pry the reusable fitting loose from the collet Older reusable fittings do not have holes in their s...

Страница 71: ...injector port 6 of the sample manager Warning To avoid burn injuries set the column temperature to Off and then allow the column compartment and its components to cool for 60 min before touching them...

Страница 72: ...sembly to the optional in line filter or to the column To install the new active preheater assembly 1 Loosen the stainless steel cap nut from the gold fitting 2 Finger tighten the gold fitting with th...

Страница 73: ...urn injuries set the column temperature to Off and then allow the column compartment and its components to cool for 60 minutes before touching them Monitor the column compartment internal temperature...

Страница 74: ...inlet tubing from injector port 6 of the sample manager 3 Open the column heater door 4 Using the Phillips screwdriver loosen the two screws that fasten the column stabilizer assembly to the column c...

Страница 75: ...ermal gasket Ensure that the thermal gasket uniformly envelops the sides of the column stabilizer and does not bunch beneath it Column stabilizer assembly two styles TP03425 Column stabilizer inlet tu...

Страница 76: ...r to the injector Requirement Do not route the tubing behind the sample manager door hinge 5 Remove the O ring retainer from the inlet end of the column stabilizer tubing Then connect the inlet tubing...

Страница 77: ...it Required materials Gloves clean powder free chemical resistant Replacement frit Required tools 5 16 inch open end wrench 2 To replace the frit in the in line filter unit 1 After allowing sufficient...

Страница 78: ...r unit by placing two 5 16 inch open end wrenches onto the flats as shown 5 Remove the in line filter unit inlet nut which contains the used frit Tips Discard the frit it cannot be reused Over time th...

Страница 79: ...mbled components to the column compartment Cleaning the instrument s exterior Clean surfaces of the solvent manager using only a clean soft lint free paper or clean cloth dampened with water Warning T...

Страница 80: ...4 Maintenance Procedures 80 September 2019 715003738IVD Rev C...

Страница 81: ...ls Warning symbols alert you to the risk of death injury or seriously adverse physiological reactions associated with an instrument s use or misuse Heed all warnings when you install repair or operate...

Страница 82: ...ment s user documentation for important safety related information before you use the instrument Warning Risk of burn injury from contacting hot surfaces Warning Risk of electric shock Warning Risk of...

Страница 83: ...uish all nearby flames Do not use tubing that is or has been stressed or kinked Do not expose nonmetallic tubing to incompatible compounds like tetrahydrofuran THF and nitric or sulfuric acids Be awar...

Страница 84: ...Warning To avoid personal contamination with biologically hazardous toxic or corrosive materials you must understand the hazards associated with their handling Guidelines prescribing the proper use a...

Страница 85: ...de la conformit la r glementation peut annuler le droit de l utilisateur exploiter l quipement Achtung Jedwede nderungen oder Modifikationen an dem Ger t ohne die ausdr ckliche Genehmigung der f r die...

Страница 86: ...se trouvant proximit de l instrument Evitez d utiliser des tubes s v rement d form s ou endommag s Evitez d utiliser des tubes non m talliques avec du t trahydrofurane THF ou de l acide sulfurique ou...

Страница 87: ...l dimetilsolfossido provocano rigonfiamenti nei tubi non metallici riducendo notevolmente la pressione di rottura dei tubi stessi Advertencia se recomienda precauci n cuando se trabaje con tubos de po...

Страница 88: ...A Safety Advisories 88 September 2019 715003738IVD Rev C Nonmetallic Tetrahydrofuran THF Methylene chloride Dimethyl sulfoxide THF...

Страница 89: ...e par le mat riel risque d tre d fectueuses Vorsicht Der Benutzer wird darauf aufmerksam gemacht dass bei unsachgem er Verwenddung des Ger tes die eingebauten Sicherheitseinrichtungen unter Umst nden...

Страница 90: ...u type et de la puissance indiqu s sur le panneau proximit du couvercle de la boite fusible de l instrument Vorsicht Zum Schutz gegen Feuer die Sicherungen nur mit Sicherungen ersetzen deren Typ und N...

Страница 91: ...s la rubrique Rem placement des fusibles du chapitre traitant des proc dures de maintenance Vorsicht Zum Schutz gegen Feuer die Sicherungen nur mit Sicherungen ersetzen deren Typ und Nennwert im Absch...

Страница 92: ...ymbols The following electrical symbols and their associated statements can appear in instrument manuals and on an instrument s front or rear panels Electrical power on Electrical power off Standby Di...

Страница 93: ...5003738IVD Rev C 93 Handling symbols The following handling symbols and their associated statements can appear on labels affixed to the packaging in which instruments devices and component parts are s...

Страница 94: ...A Safety Advisories 94 September 2019 715003738IVD Rev C...

Страница 95: ...l information about specifications Physical specifications The following table lists the physical specifications for the ACQUITY UPLC I Class IVD column heater Contents Topic Page Physical specificati...

Страница 96: ...Attribute Specification Operating temperature 4 to 40 C 39 2 to 104 F Operating humidity 20 to 80 noncondensing Transportation and storage temperature 30 to 60 C 22 to 140 F Transportation and storage...

Страница 97: ...mass spectrometer Fittings 124 106 kPa 1241 bar 18 000 psi low dispersion with reusable column inlet fittings Column compartment temperature range 20 to 90 C in increments of 0 1 C control requires a...

Страница 98: ...w Measurement taken with traceable external temperature measurement device Measurement taken after one hour of thermal equilibration at setpoint Measurement taken at column compartment sensor location...

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