27. Yamanaka S. Strategies and new developments in the generation of patient-specific
pluripotent stem cells.
Cell Stem Cell
2007;
1
: 39
–
49.
28. Rowland BD, Bernards R, Peeper DS. The KLF4 tumour suppressor is a transcriptional
repressor of p53 that acts as a context-dependent oncogene.
Nat Cell Biol
2005;
7
:
1074
–
1082.
29. Hunt CR, Ro JH, Dobson DE, Min HY, Spiegelman BM. Adipocyte P2 gene: developmental
expression and homology of 5'-flanking sequences among fat cell-specific genes.
Proc Natl
Acad Sci USA
1986;
83
: 3786
–
3790.
30. Maxwell PH, Wiesener MS, Chang G-W, Clifford SC, Vaux EC, Cockman ME
et al.
The
tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent
proteolysis.
Nature
1999;
399
: 271
–
275.
31. Iavarone C, Catania A, Marinissen MJ, Visconti R, Acunzo M, Tarantino C
et al.
The platelet-
derived growth factor controls c-myc expression through a JNK- and AP-1-dependent
signaling pathway.
J Biol Chem
2003;
278
: 50024
–
50030.
32. Sarjeant K, Stephens JM. Adipogenesis.
Cold Spring Harb Perspect Biol
2012;
4
: a008417.
33. Umezawa A, Maruyama T, Segawa K, Shadduck RK, Waheed A, Hata J. Multipotent marrow
stromal cell line is able to induce hematopoiesis
in vivo
.
J Cell Physiol
1992;
151
: 197
–
205.
34. Kuri-Harcuch W, Green H. Adipose conversion of 3T3 cells depends on a serum factor.
Proc
Natl Acad Sci USA
1978;
75
: 6107
–
6109.
35. Green H, Meuth M. An established pre-adipose cell line and its differentiation in culture.
Cell
1974;
3
: 127
–
133.
36. Cristancho AG, Lazar MA. Forming functional fat: a growing understanding of adipocyte
differentiation.
Nat Rev Mol Cell Biol
2011;
12
: 722
–
734.
37. Siersbaek R, Nielsen R, Mandrup S. Transcriptional networks and chromatin remodeling
controlling adipogenesis.
Trends Endocrin Metab
2012;
23
: 56
–
64.
38. Ali AT, Hochfeld WE, Myburgh R, Pepper MS. Adipocyte and adipogenesis.
Eur J Cell Biol
2013;
92
: 229
–
236.
39. Niwa H, Ogawa K, Shimosato D, Adachi K. A parallel circuit of LIF signalling pathways
maintains pluripotency of mouse ES cells.
Nature
2009;
460
: 118
–
122.
40. Simon AR, Rai U, Fanburg BL, Cochran BH. Activation of the JAK-STAT pathway by reactive
oxygen species.
Am J Physiol Cell Physiol
1998;
275
: C1640
–
C1652.
41. McConnell BB, Yang VW. Mammalian Kruppel-like factors in health and diseases.
Physiol
Rev
2010;
90
: 1337
–
1381.
42. Freytag SO. Enforced expression of the c-myc oncogene inhibits cell differentiation by
precluding entry into a distinct predifferentiation state in G0/G1.
Mol Cell Biol
1988;
8
:
1614
–
1624.
43. Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W
et al.
c-Myc is a universal amplifier of
expressed genes in lymphocytes and embryonic stem cells.
Cell
2012;
151
: 68
–
79.
44. Rodeheffer MS, Birsoy K, Friedman JM. Identification of white adipocyte progenitor cells
in vivo
.
Cell
2008;
135
: 240
–
249.
45. Uezumi A, Fukada S, Yamamoto N, Takeda S, Tsuchida K. Mesenchymal progenitors distinct
from satellite cells contribute to ectopic fat cell formation in skeletal muscle.
Nat Cell Biol
2010;
12
: 143
–
152.
46. Bolli R, Chugh AR, D'Amario D, Loughran JH, Stoddard MF, Ikram S
et al.
Cardiac stem cells
in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase
1 trial.
Lancet
2011;
378
: 1847
–
1857.
47. Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D
et al.
Intracoronary
cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a
prospective, randomised phase 1 trial.
Lancet
2012;
379
: 895
–
904.
48. Smits AM, van Vliet P, Metz CH, Korfage T, Sluijter JP, Doevendans PA
et al.
Human
cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an
in vitro
model for studying human cardiac physiology and pathophysiology.
Nat Protocols
2009;
4
:
232
–
243.
49. Pouliopoulos J, Chik WW, Kanthan A, Sivagangabalan G, Barry MA, Fahmy PN
et al.
Intramyocardial adiposity post-myocardial infarction: new implications of a substrate for
ventricular tachycardia.
Circulation
2013;
128
: 2296
–
2308.
50. Hou X, Zhang Y, Shen YH, Liu T, Song S, Cui L
et al.
PPAR-gamma activation by
rosiglitazone suppresses angiotensin II-mediated proliferation and phenotypictransition in
cardiac fibroblasts via inhibition of activation of activator protein 1.
Eur J Pharmacol
2013;
715
: 196
–
203.
51. Wang C, Mayer JA, Mazumdar A, Fertuck K, Kim H, Brown M
et al.
Estrogen induces c-myc
gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1
transcription factor.
Mol Endocrinol
2011;
25
: 1527
–
1538.
52. Zhang Y, Wang Y, Liu Y, Wang N, Qi Y, Du J. Kruppel-like factor 4 transcriptionally regulates
TGF-beta1 and contributes to cardiac myofibroblast differentiation.
PloS One
2013;
8
:
e63424.
53. Gabrielsen A, Lawler PR, Yongzhong W, Steinbruchel D, Blagoja D, Paulsson-Berne G
et al.
Gene expression signals involved in ischemic injury, extracellular matrix composition and
fibrosis defined by global mRNA profiling of the human left ventricular myocardium.
J Mol
Cell Cardiol
2007;
42
: 870
–
883.
54. Boengler K, Hilfiker-Kleiner D, Drexler H, Heusch G, Schulz R. The myocardial JAK/STAT
pathway: from protection to failure.
Pharmacol Ther
2008;
120
: 172
–
185.
55. Holmstrom KM, Finkel T. Cellular mechanisms and physiological consequences of redox-
dependent signalling.
Nat Rev Mol Cell Biol
2014;
15
: 411
–
421.
56. Funato Y, Michiue T, Asashima M, Miki H. The thioredoxin-related redox-regulating protein
nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled.
Nat Cell Biol
2006;
8
:
501
–
508.
57. Huang, da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene
lists using DAVID bioinformatics resources.
Nat Prot
2009;
4
: 44
–
57.
58. Fukai K, Nakamura A, Hoshino A, Nakanishi N, Okawa Y, Ariyoshi M
et al.
Pyk2 aggravates
hypoxia-induced pulmonary hypertension by activating HIF-1alpha.
Am J Physiol Heart Circ
Physiol
2015;
308
: H951
–
H959.
59. Michael LH, Entman ML, Hartley CJ, Youker KA, Zhu J, Hall SR
et al.
Myocardial
ischemia and reperfusion: a murine model.
Am J Physiol
1995;
269
(6 Pt 2):
H2147
–
H2154.
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Cardiac adiposity is regulated by
Klf4
and
c-Myc
D Kami
et al
12
Cell Death and Disease
