IMS MM1000, Инструкция по эксплуатации

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No toxic effects or abnormal histopathological observations occurred in rats repeatedly exposed to
concentrations ranging from 10,000 to 50,000 ppm (v/v). Long-term exposures to 50,000 ppm (v/v)
of vapors produced organ weight increases and a decrease in body weight gain, but no increased
mortality or adverse hematological effects, In chronic inhalation studies, HCFC-22, at a
concentration of 50,000 ppm (vlv), produced a small, but statistically significant increase of late-
occurring tumors involving salivary glands in male rats, but not female rats or male or female mice.
In the same studies, no increased incidence of tumors was seen in either species at concentrations of
10,000 ppm or 1,000 ppm (v/v).
Long-term administration in corn oil produced no effects on body weight or mortality.
HCFC-22 was mutagenic in some strains of bacteria in bacterial cell cultures, but not mammalian
cell cultures or animals. It did not cause heritable genetic damage in
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2008FR
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TOXICOLOGICAL INFORMATION
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mammals.
Single exposure caused: Cardiac sensitation, a potentially fatal disturbance of heart rhythm
associated with a heightened sensitivity to the action of epinephrine. Lowest-Observed-Adverse-
Effect-Level for cardiac sensization: 75,000 ppm. Single exposure caused: Lethargy. Narcosis.
Incrased respiratory rates. These effects were temporary. Single exposure to near lethal doses caused:
Pulmonary edema. Repeated exposure to caused: Increased adrenals, liver, spleen weight. Decreased
uterine, prostate weight. Repeated dosing of higher concentrations caused: the following tempoerary
effects- Tremors. Incoordination.
CARCINOGENIC, DEVELOPMENTAL, REPRODUCTIVE, MUTAGENIC EFFECTS:
In a two-year inhalation study, HFC-134A, at a concentration of 50,000 ppm, produced an increase
in late-occuring benign testicular tumors, testicular hyperplasia and esticular weight. The no-effect-
level for this study was 10,000 ppm. Animal data show slight fetoxicity but only
ECOLOGICAL INFORMATION
ECOTOXICOLOGICAL INFORMATION
Aquatic Toxicity:
HCFC-22 48 hour EC50 - Daphnia magna: 433 mgiL
DISPOSAL CONSIDERATIONS
WASTE DISPOSAL