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CryoProbe Prodigy Safety

H171764_6_001

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7

CryoProbe Prodigy Safety

The Prodigy system is an accessory for an NMR-spectrometer and consists of a CryoProbe
Prodigy, a vacuum-insulated transfer line for liquid nitrogen, a dewar for liquid nitrogen (LN2
Dewar) with a permanent installed dewar adaptor and a Prodigy Unit for the control of the
CryoProbe Prodigy.

The  CryoProbe  Prodigy  is  a  NMR  probe  with  integrated  Cryo-preamplifiers.  The  NMR  coil
assembly and the Cryo-preamplifier are cooled by evaporation of liquid nitro-gen (LN2). The
advantage of this cooling method is to achieve extremely efficient operation of the NMR coil
assembly  and  to  significantly  reduce  thermal  noise.  These  combined  efforts  drastically
enhance  the  overall  signal-to-noise  ratio  compared  to  room  temperature  NMR
measurements.

LN2 is transferred to the probe from the LN2 Dewar via the LN2 transfer line. The CryoProbe
is an open system, meaning that gaseous nitrogen is discharged into the atmosphere through
an exhaust on the probe. A special exhaust heater is used to heat up and evaporate any
excess LN2 droplets at the exhaust. The cold parts inside the probe are thermally insulated
by vacuum, which is evacuated by a roughing and turbo pump located in the Prodigy Unit.

For additional Prodigy safety and related information, refer to the CryoProbe Prodigy System
User Manual (P/N Z31986), available on the BASH DVD or from Bruker.

As the CryoProbe Prodigy system is used in conjunction with a magnet system, also refer to
the

Magnet Safety [

chapter in this manual.

7.1

Personnel Safety Issues

All persons who work with or in the close vicinity of an NMR system must be informed about
its safety issues and emergency procedures.

If in doubt: Wear goggles and protective gloves, particularly when handling samples!

Inherent Safety

An NMR system, including its components, is designed for inherent safety. Pressure relief
valves, sensors, and error handling in hardware and software have been included to protect
the operator, equipment, and environment.

Technically Qualified Personnel Only

Only persons with a basic technical understanding of electricity, pressurized gas systems,
and cryogens should operate and maintain an NMR system. User interface, system
messages, and manuals require a good understanding of the English language.

No User-serviceable Parts Inside

There are no user-serviceable parts inside a probe/CryoProbe. Do not open these devices.

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Содержание NMR AVANCE NEO Systems

Страница 1: ...AVANCE NEO Systems General Safety Considerations User Manual Version 001 Innovation with Integrity NMR ...

Страница 2: ... registered trademarks of their re spective holders This manual was written by Bruker BioSpin Group August 16 2018 Bruker Corporation Document Number 10000061249 P N H171764 For further technical assistance for this product please do not hesitate to contact your nearest BRUKER dealer or contact us directly at Bruker Corporation Am Silberstreifen 76287 Rheinstetten Germany Phone 49 721 5161 6155 E ...

Страница 3: ...s 13 3 2 System Grounding and Potential Equalization of Avance Systems 13 3 3 Console Safety 15 3 3 1 Normal Shutoff 15 3 3 2 Emergency Shutoff 16 3 4 AVANCE NEO AQS 17 3 4 1 Emergency Shutoff 17 3 4 2 Personnel Safety 17 3 5 BSMS 2 18 3 5 1 Emergency Shutoff 18 3 5 2 Personnel Safety 18 3 6 Transmitter Safety 19 3 6 1 Transmitter Safety 19 3 6 1 1 Safety Labels 20 3 6 2 Emergency Shutoff 20 4 Mag...

Страница 4: ...um Refill Instructions 28 4 5 3 Rapid Helium Transfer 28 4 6 Ventilation 28 4 6 1 Ventilation During Normal Operation 29 4 6 2 Emergency Ventilation During Magnet Installation or a Quench 29 4 6 3 Emergency Exhaust 29 4 6 4 Oxygen Monitor and Level Sensors 30 5 Probe Safety Considerations 31 5 1 Personnel Safety Issues 31 5 1 1 First Aid 32 6 CryoProbe Safety 33 6 1 Emergency Shutoff 33 6 2 Person...

Страница 5: ...products as new techniques and components become available Bruker reserves the right to change specifications at any time Every effort has been made to avoid errors in text and figure presentation in this publication In order to produce useful and appropriate documentation we welcome your comments on this publication Field Service Engineers are advised to check regularly with Bruker for updated in...

Страница 6: ...condition u This is the safety instruction NOTICE NOTICE Indicates information considered important but not hazard related e g messages relating to property damage This is the consequence of not following the notice 1 This is a safety condition u This is a safety instruction SAFETY INSTRUCTIONS SAFETY INSTRUCTIONS are used for control flow and shutdowns in the event of an error or emergency This i...

Страница 7: ... of a field strength between 7 T to over 20 T with room temperature bore sizes between 54 mm and 155 mm Typical sample amounts range from nanogram to less than gram level The method allows to identify and or confirm the structure of chemical and biochemical compounds and mixtures including information concerning molecular mobility and interactions The method is also used to obtain information abou...

Страница 8: ... is brought too close it may suddenly be drawn into the magnet with surprising force This may damage the magnet or cause personal injury to anybody in the way Because the strength of the stray field drops significantly as one moves away from the magnet it is useful to discuss safety in terms of two broadly defined regions the inner and outer zone In terms of organizing a laboratory as well as defi...

Страница 9: ...edure Helium and nitrogen are non toxic gases However because of a possible magnet quench whereupon the room may suddenly fill with evaporated gases adequate ventilation must always be provided 2 5 Electrical Safety The spectrometer hardware is no more or less hazardous than any typical electronic or pneumatic hardware and should be treated accordingly Do not remove any of the protective panels or...

Страница 10: ...d labels always relate to their immediate vicinity The following signs and labels are found on or around the spectrometer system Prohibition sign No person with pacemakers People with pacemakers are endangered in the marked area and are not allowed to enter these areas Prohibition sign No person with implants People with metallic implants are endangered in the marked area and are not allowed to en...

Страница 11: ...ewelry No metallic items Hazard warning sign Risk of damage to life and limb due to electricity and high voltage Risk of damage to life and limb due to contact with electrical lines and damaged isolation or Electrostatic Sensitive Device Observe precautions for handling Protective Ground Earth Terminal Used to identify any terminal which is connected to the external protective conductor or protect...

Страница 12: ... cm feet ft inch in 1 m 3 28 ft 1 m 39 37 in 1 cm 0 394 in Area square meter m 2 square foot ft 2 1 m 2 10 76 ft 2 Volume cubic meter m 3 liter l cubic foot ft 3 quart qt 1 m 3 35 32 ft 3 1 l 1 06 qt liquid Weight kilogram kg pounds lbs 1 kg 2 21 lbs Pressure bar pounds square inch psi atmosphere ATM 1 bar 14 51 psi 1 bar 0 99 ATM standard Temperature C F F C 1 8 32 F C C F 32 1 8 Magnet Field Str...

Страница 13: ...r s site To establish a complete potential equalization of the whole system each system is delivered with grounding cables that have to be attached to the console the HPPR and the magnet as follows A cable must be connected from the central grounding point located on the lower backside of the cabinet to the grounding of the building When an external preamplifier HPPR 2 is used a cable has to be co...

Страница 14: ...Cabinet Safety 14 48 H171764_6_001 Figure 3 1 AVANCE Spectrometer with Internal Preamp Figure 3 2 AVANCE Spectrometer with External Preamp HPPR 2 ...

Страница 15: ...s TwoBay consoles should only be moved by two persons 3 3 1 Normal Shutoff A Power Distribution Unit PDU in the back of the console is used to power up the spectrometer in a controlled way It is possible to power up down the AVANCE by a software instruction from TopSpin The PDU takes care that all units are powered up down in the correct order and that high power units are switched on with suitabl...

Страница 16: ...U must be switched off by using the mains switch described in the next section 3 3 2 Emergency Shutoff The mains switch powers down the console including the PDU after a controlled shutdown The mains switch of the AVANCE consoles also serves as an EMERGENCY OFF for instance if no controlled shutdown through the PDU is possible Figure 3 5 Location of the Emergency Shutoff on the AVANCE NEO Series ...

Страница 17: ... not advised to selectively switch off the AQS Instead shutdown the console completely Only if otherwise instructed by Bruker personnel you may be guided through a process to selectively shutdown the AQS 3 4 2 Personnel Safety Ground Connection WARNING To minimize shock hazard the AQS chassis must be connected to an electrical ground The electronics cabinet is equipped with a three conductor AC po...

Страница 18: ... be observed during all phases of operation and service of the BSMS 2 system Failure to comply with these precautions or with specific warnings elsewhere in this manual violates safety standards of design manufacture and intended use of the BSMS 2 system BRUKER assumes no liability for the customer s failure to comply with these requirements and is therefore not responsible or liable for any injur...

Страница 19: ...d to insert and remove the BSMS 2 chassis from the electronics cabinet A fully equipped BSMS 2 system can weight more than 50 kg NOTE Remove some or all of the BSMS 2 units from the chassis prior to handling to reduce weight Cleaning WARNING Always switch power off and disconnect the power cable before cleaning Never power on until all surfaces are completely dry Clean the outside of the BSMS 2 ch...

Страница 20: ...pSpin command line or click on the STOP icon in the TopSpin menu bar When in doubt turn off the RF transmitter Disconnect the mains power cable before opening the unit to prevent risk of electrical shock 3 6 2 Emergency Shutoff In case of an emergency use the mains switch described in the console Emergency Shutoff 16 to switch off the complete console The amplifier in AVANCE NEO systems can only b...

Страница 21: ...es are placed and maintained to effectively warn people that they are entering a hazardous area All health and safety procedures are observed These notes outline aspects of operation and installation which are of particular importance However the recommendations given cannot cover every eventuality and if any doubt arises during the operation of the system the user is strongly advised to contact t...

Страница 22: ...r even stopped in the presence of either static or changing magnetic fields Not all pacemakers respond in the same way or at the same field strength if exposed to fields above 5 gauss 4 1 3 Surgical Implants and Prosthetic Devices The following must be understood concerning the effects on surgical implants and prosthetic devices Besides electronic electrical and mechanical medical implants other m...

Страница 23: ...inimum requirements Every magnet site location should be reviewed individually to determine the precautions needed to be taken against these hazards Consideration must be given to floors above and below the magnet as well as the surrounding space at the same level since the magnetic field produced by the NMR magnets is three dimensional 4 2 Controlled Access Area For equipment that generates a str...

Страница 24: ...comes a liquid at approximately 4 K It is colorless odorless non flammable and non toxic In order to remain in a superconducting state the magnet is immersed in a bath of liquid helium Nitrogen This is a naturally occurring gas that becomes liquid at approximately 77K It is also colorless odorless non flammable and non toxic It is used to cool the shields which surround the liquid helium reservoir...

Страница 25: ...oduct losses All cryogen transport dewar must be constructed of non magnetic materials 4 3 4 Health Hazards Main health hazard related rules include but are not limited to Evacuate the area immediately in the event of a large spillage Provide adequate ventilation in the room to avoid oxygen depletion Helium can displace air in the upper area of a room and cold nitrogen can displace air in the lowe...

Страница 26: ...by flexible metal or Teflon hose for transferring liquid nitrogen Use only gum rubber or Teflon tubing Do not use Tygon or plastic tubing They may split or shatter when cooled by the liquid flowing through it and could cause injury to personnel 4 3 8 Smoking Please obey the following basic rules concerning smoking Do not smoke in any rooms in which cryogenic liquids are being handled Designate all...

Страница 27: ... on the nitrogen neck tubes during refill Stop the transfer immediately when the vessel is full Failure to observe this can lead to the freezing of the o rings and a subsequent vacuum loss of the magnet cryostat 4 5 Liquid Helium Refill Please read this section carefully and make it accessible to anybody working with the magnet system A shielded superconducting NMR Magnet System can be operated ea...

Страница 28: ... the magnet Always allow the helium transfer line to cool down to helium temperature before inserting it into the right helium neck tube You should see liquid helium leaving of the short end transfer lines for a few moments before inserting it into the right helium neck tube 4 5 3 Rapid Helium Transfer Do not remove the nitrogen security flow system during any transfer liquid helium During a rapid...

Страница 29: ...ded to prevent oxygen depletion in case of a quench or during the magnet installation During a quench an extremely large quantity of helium gas i e 43 to 595 m3 depending on the magnet type is produced within a short time During the installation and cooling of superconducting magnets and under certain conditions large volumes of nitrogen or helium gases may be generated Although these gases are in...

Страница 30: ...s from happening in all atmospheric conditions and winds Insulation of accessible exhaust piping should also be provided to prevent cold burns during a quench Exhaust for Magnet Pits Special attention to ventilation and emergency exhaust must be given when magnets are placed inside pits Magnet pits are confined spaces with a possibility of increased risk of oxygen depletion if appropriate exhaust ...

Страница 31: ...ut its safety issues and emergency procedures If in doubt Wear goggles and protective gloves particularly when handling samples Inherent Safety An NMR system including its components is designed for inherent safety Pressure relief valves sensors and error handling in hardware and software have been included to protect the operator equipment and environment Technically Qualified Personnel Only Only...

Страница 32: ...rious hazards The danger zone should be labelled as precise as possible by the use of barriers floor taping or visual warning devices Consult your safety manual for specific information concerning the danger zone 0 5 mT 5 Gauss line Strictly enforce the smoking ban during refill procedures 5 1 1 First Aid If cold helium or nitrogen gas comes in contact with eyes or skin immediately flood the affec...

Страница 33: ...cludes the CryoCooling Unit the He Compressor the mounting hardware at the magnet etc It is compatible with all BRUKER CryoProbes and only one per spectrometer is needed For additional CryoProbe safety and related information refer to the CryoProbe System User Manual P N Z31551 available on the BASH DVD or from Bruker As the CryoProbe system is used in conjunction with a magnet system also refer t...

Страница 34: ...le Parts Inside There are no user serviceable parts inside a probe CryoProbe Do not open these devices Magnetic Stray Field When working within the 0 5 mT 5 Gauss stray field of the magnet all magnetic parts and tools must be avoided or handled with great care CAUTION Deposit mechanical watches and cards with a magnetic strip e g credit cards outside the 0 5 mT 5 Gauss range of the magnet General ...

Страница 35: ...ds If crossing of walkways cannot be avoided the He Hose must be covered or buried Moreover the He Hose must be fixed to a wall or to the floor once every meter WARNING If the He Hose is not fixed it can whip around in case of a rupture WARNING If a large quantity of helium gas escapes from the He steel cylinder during a short period there is a danger of suffocation particularly in small rooms Goo...

Страница 36: ...ews can destroy factory settings and will in general render the CryoProbe unusable Never force a CryoCoupler into position Do not obstruct the operation of the safety valves on the top and front faces of the CryoProbe body Never force a CryoCoupler into position Do not move a cryogenically cold device Do not try to fix a leak on a cold part because cracking of frozen O rings valves etc may occur E...

Страница 37: ...The cold parts inside the probe are thermally insulated by vacuum which is evacuated by a roughing and turbo pump located in the Prodigy Unit For additional Prodigy safety and related information refer to the CryoProbe Prodigy System User Manual P N Z31986 available on the BASH DVD or from Bruker As the CryoProbe Prodigy system is used in conjunction with a magnet system also refer to the Magnet S...

Страница 38: ...hould not be accessible to the public Make sure access is restricted to authorized and qualified persons only Strong magnetic fields involve various hazards The danger zone should be labelled as precise as possible by the use of barriers floor taping or visual warning devices Consult your safety manual for specific information concerning the danger zone 0 5 mT 5 Gauss line Strictly enforce the smo...

Страница 39: ...ce centers Bruker BioSpin NMR provides dedicated hotlines and service centers so that our specialists can respond as quickly as possible to all your service requests applications questions software or technical needs Please select the NMR service center or hotline you wish to contact from our list available at https www bruker com service information communication helpdesk html Phone 49 721 5161 6...

Страница 40: ...Contact 40 48 H171764_6_001 ...

Страница 41: ...re 3 1 AVANCE Spectrometer with Internal Preamp 14 Figure 3 2 AVANCE Spectrometer with External Preamp HPPR 2 14 Figure 3 3 The Power Distribution Unit 15 Figure 3 4 The PDU Display 16 Figure 3 5 Location of the Emergency Shutoff on the AVANCE NEO Series 16 ...

Страница 42: ...List of Figures 42 48 H171764_6_001 ...

Страница 43: ...List of Tables H171764_6_001 43 48 List of Tables Table 2 1 Spectrometer System Operating Environment 10 Table 2 2 Signs and Labels 10 Table 2 3 SI to U S Conversion Factors 12 ...

Страница 44: ...List of Tables 44 48 H171764_6_001 ...

Страница 45: ...3 CryoPlatform 33 CryoProbe Prodigy 37 CryoProbes 33 H He Compressor 33 M Magnet quench 9 Metallic implants 8 P Prodigy Unit 37 S Safety Chemical 9 Safety Cryogenic 9 Safety Electrical 9 Safety Outer zone precautions 9 Site Planning Guide 8 Stray fields 8 Symbols and Conventions Safety 5 ...

Страница 46: ...Index 46 48 H171764_6_001 ...

Страница 47: ...H171764_6_001 47 48 ...

Страница 48: ...Bruker Corporation info bruker com www bruker com Order No H171764 ...

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