Waters Xevo TQD, Operator'S, Overview And Maintenance Manual

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Uses and compatibility 1-7
biomarker discovery and proteomics applications, including protein
identification and characterization.
This system is optimized for high-resolution separations at precise nanoflow
rates. With closed-loop control, those rates range between 0.20 and
5.00 µL/min. With open-loop control and nanoACQUITY UPLC columns of
internal diameters ranging from 75 µm to 1 mm, the flow rates can extend to
100 µL/min. The column hardware and the matched outlet tubing can
withstand pressure of as much as 69,000 kPa (690 bar, 10,000 psi). The
column dimensions allow optimal MS-compatible flow rates, and matched
outlet tubing minimizes the effect of extra-column volume.
For further instruction, see the
nanoACQUITY UPLC System Operator’s
Guide or Controlling Contamination in LC/MS Systems (part number
715001307). You can find these documents on http://www.waters.com; click
Services and Support > Support.
Non-ACQUITY devices for use with the Xevo TQD
The following non-ACQUITY LC devices are validated for use with the Xevo
TQD:
• Waters Alliance 2695 separations module
• Waters Alliance 2795 separations module
• Waters 2998 PDA detector
• Waters 2487 UV detector
• Waters 1525µ binary gradient pump + 2777 autosampler
• Spark Holland Symbiosis™ system
Software and data system
MassLynx mass spectrometry software v4.1controls the mass spectrometer. It
is a high-performance application that acquires, analyzes, manages, and
distributes mass spectrometry, ultraviolet (UV), evaporative light scattering,
and analog data.
MassLynx software enables these major operations:
• Configuring the system.
• Creating LC and MS/MS methods that define operating parameters for a
run.