Waters Xevo TQ MS, Operator And Maintenance Manual, Page: 26 / 184

1-10 Waters Xevo TQ MS Overview
MS operating modes
The following table shows the MS operating modes.
In MS mode, the instrument can acquire data at scan speeds up to
10,000 Da/s. Use this mode for instrument tuning and calibration before
MS/MS analysis. See the mass spectrometer’s online Help for further
information.
Use the selected ion recording (SIR) mode for quantitation when you cannot
find a suitable fragment ion to perform a more specific multiple reaction
monitoring (MRM) analysis. See “MS/MS operating modes” on page 1-11 .
Note:
In SIR and MRM modes, neither quadrupole is scanned, therefore no
spectrum (intensity versus mass) is produced. The data obtained from SIR or
MRM analyses derive from the chromatogram plot (specified mass intensity
versus time).
MS operating modes
Operating mode MS1 Collision cell MS2
MS Pass all masses Resolving
(scanning)
SIR Pass all masses Resolving (static)