• Superior peak capacity
• Higher sensitivity
• Faster data acquisition
• Consistent, reproducible results
The I-Class Series system is an effective tool for analyzing complex or dilute samples, providing
high resolution and reproducible results for chromatographic separations.
1.3 Binary solvent manager
The ACQUITY UPLC I-Class Series system employs a binary solvent manager that, like the
system, is optimized for sub-2-μm particle liquid chromatography and uses reduced fluid
volumes. New pressure management capabilities extend the flow rate envelope for the system to
support ballistic gradients. This support enables you to run higher flow rates and faster cycle
times to accelerate your chromatography, while maintaining the integrity of the separation.
1.4 Column compartments
Column compartments configured with ACQUITY UPLC I-Class Series systems ensure reliable
and robust separations. This is especially important when you transfer methods to other systems.
UPLC applications can benefit from pre-column, mobile-phase heating to improve
chromatographic separations.
The ACQUITY UPLC I-Class Series column compartments use an active preheater to condition
solvent as it enters the column. The preheater is a heat source that raises the temperature of the
incoming mobile phase and injected sample to the same set point as that of the column
compartment. Active solvent preheaters provide precise thermal performance with low dispersion
for exact control of chromatographic conditions that remain consistent between systems.
1.5 Injector mechanisms
ACQUITY UPLC I-Class Series system configurations include a sample manager with either a
fixed-loop or flow through needle injector mechanism. This flexibility allows you to choose the
optimum injector mechanism for your application. Both mechanisms provide high precision with
low dispersion and efficient sample recovery. The low carryover performance of the injector
mechanisms, which enables you to use a wider sample concentration range, is also beneficial for
mass spectrometry applications.
April 4, 2018, 715005704 Rev. A
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