Waters 2998, Overview And Maintenance Manual

Page: 83 / 94

December 5, 2017, 715004753 Rev. B
Page 83
C
Solvent Considerations
This appendix contains certain solvent considerations you must take into account when
operating or maintaining the 2998 PDA Detector.
C.1 Introduction
C.1.1 Clean solvents
Clean solvents provide reproducible results and permit you to operate with minimal instrument
maintenance.
A dirty solvent can cause baseline noise and drift. It can also block the solvent filters with
particulate matter.
C.1.2 Solvent quality
Use HPLC-grade solvents for the best possible results. Filter solvents through 0.45-µm filters
before their use. Solvents distilled in glass generally maintain their purity from lot to lot; use them
to ensure the best possible results.
C.1.3 Preparation checklist
The following solvent preparation guidelines help to ensure stable baselines and good resolution:
• Filter solvents with a 0.45-µm filter.
• Degas, sparge or degas and sparge the solvent.
• Stir the buffers and mixed mobile phases, if necessary.
• Keep in a place free from drafts and shock.
C.1.4 Water
Use water only from a high-quality water purification system. If the water system does not deliver
filtered water, filter it through a 0.45-µm membrane filter before use.
Warning:
To avoid chemical hazards, always observe Good Laboratory Practices
when operating your system.