500 L HyPerforma DynaDrive Single-Use
Bioreactor Quick Start Guide
This Guide provides a brief overview of setting up the Thermo Scientific
™
HyPerforma
™
DynaDrive Single-Use Bioreactor (S.U.B.)
system. For more detailed information about the DynaDrive S.U.B., refer to the 50 and 500 L HyPerforma DynaDrive S.U.B. User’s
Guide (DOC0090).
Warnings and safety
Hazardous voltage inside
—
risk of electrical
shock.
Service should be provided by certified
personnel only.
Hot surface
—do not touch
.
The heating jacket is designed to heat the inner
vessel wall. Contact with surfaces may cause
burns.
Pinch hazard.
Use caution when opening/
closing the door, securing the BPC to the
top and bottom ports in the tank, and during
operation of the DynaDrive S.U.B.
Burst hazard
—
air under pressure.
Do not
exceed 30 mbar (0.5 psi) BPC pressure. Do
not exceed 34 mbar (5 psi) inlet pressure.
Ensure that the vent filter is correctly positioned
and working properly.
Tipping hazard. The vessel should only
be moved by pushing using the provided
handles or at the mid-point of the vessel.
If pulled or moved too quickly, the vessel can
tip, potentially leading to damage to equipment
or injury to personnel. To reduce the risk of
tipping, the vessel should only be moved
slowly over smooth, flat surfaces by at least
two qualified personnel. During movement, any
locking feet should be retracted, and casters
should be in the unlocked position. The vessel
should not be moved by pulling of any kind.
The Thermo Scientific HyPerforma
DynaDrive S.U.B. may not be installed in
a potentially explosive atmosphere as set
forth in the applicable EU ATEX Directive.
It is the responsibility of the end user to review
and understand the potential dangers listed in
the ATEX 2014/34/EU guidelines.
Static electricity may build up in BPCs.
• BioProcess Containers (BPCs) may act
as insulators for electrostatic charge. If
electrostatic charge is transferred to a BPC,
the charge may be stored in the BPC and/or
the product inside. This phenomena varies
by product and use; therefore, it is the sole
responsibility of the end user to ensure a
hazard assessment is conducted and the
risk of electrostatic shock is eliminated.
• Where applicable, a product contact
stainless steel coupler may be grounded
to the frame to dissipate electrostatic
buildup from the material within a BPC. It
is good practice to dissipate electrostatic
buildup by grounding all BPCs prior to
coming in contact with them. When working
with BPCs, the use of nonconductive
materials, such as nonconductive gloves, is
recommended.
Rotating parts—entanglement hazard.
Rotating and moving parts can cause injury.
Keep hands away from moving parts during
operation. Do not operate this equipment unless
the supplied guarding is in place and properly
functioning. It is the responsibility of the end
user to assess this equipment and ensure that
equipment and safeguards are in good working
condition, and that all operators are trained and
aware of entanglement hazards and associated
protective devices, such as hazard signs and
guarding.
