Pitch is only one of the synth parameters and adjustable semitone-wise without any
musical scale assistance, so there may be better editors for plain harmonic melodies.
Nanoloop is not sample based, but gives full access to the built-in features of the
GB's sound chips (like the various noise-"colors") plus software-synthesis. The
sound chips are analogoue oscillators with digital control registers for volume,
pitch, etc. The softsynth is based on the writable harware wavetable and uses the
possibility of quick frequency changes for FM. So there is no digital distortion by
sample rate or bit depth except for the wavetable. The contained wave form is a
sample of 32 bytes with 4 bit depth and it's sampling frequency depends on pitch.
On very low pitch this results in crispy "digital" sound while a sine wave for
example sounds rather smooth on higher pitch.