MULTICHANNEL SYSTEMS MEA 1060-Inv, Manual

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Operating
17
5.4 Stimulation
Recommended stimulus protocols for MEA electrodes
MCS recommends to use biphasic stimulation pulses only with negative phase first. The duration
of each phase should be 100
μ s and the amplitude between 100 mV and 3000 mV. (See also
Potter, S. M., Wagenaar, D. A. and DeMarse, T. B. (2005). Closing the Loop: Stimulation Feedback
Systems for Embodied MEA Cultures. Advances in Network Electrophysiology Using Multi-
Electrode Arrays. M. Taketani and M. Baudry, Springer; Wagenaar, D. A., Madhavan, R., Pine, J.
and Potter, S. M. (2005). "Controlling bursting in cortical cultures with closed-loop multi-electrode
stimulation." J Neurosci 25(3): 680-8.)
Stimulation with MEA electrodes
You can use any MEA electrode for stimulation. Simply connect the output channel(s)
of your stimulus generator to the input socket(s) of any desired electrode(s).
You should use the dip switches for connecting stimulating electrodes with the ground.