Logitech MX ERGO, Online Manual

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A MORE NATURAL HAND POSITION
Imaging sleeping in space, or in water. Naturally, your body will take a natural
fetal position where all the muscles and tendons are at rest. The forearm and
hand will take a vertical position, just like in a handshake.
Poor posture has been identified as one of the key risk factors for Repetitive
Strain Injury (RSI). The goal of ergonomics is to moved toward natural
postures. However, by being used on the table, the mouse forces the hand to
be in a more horizontal, pronated position.
The trackball and in particular the MX ERGO, by its innovative design, allows
the forearm to rotate clockwise and reduces the stress on the muscles
holding the 2 forearm bones: the Radial and Ulnar.