Lexus 2012 RX350, Owner'S Manual

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2-1. Driving procedures
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When driving with cruise control or radar cruise control activated
Even when performing the following actions with the intent of enabling engine
braking, engine braking will not activate while driving in S mode and downshifting
to 5 or 4 because cruise control or radar cruise control will not be canceled.
(

P. 291, 296)
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If the shift lever cannot be shifted from P

P. 916
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If S does not come on or D comes on even after shifting the shift lever to S
This may indicate a malfunction in the automatic transmission system. Have the
vehicle inspected by your Lexus dealer immediately.
(In this situation, the transmission will operate in the same as manner as when the
shift lever is in D.)
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Downshift restriction warning buzzer (S mode)
To help ensure safety and driving performance, downshifting operation may some-
times be restricted. In some circumstances, downshifting may not be possible even
when the shift lever or paddle shift switch is operated. (The warning buzzer will
sound twice.)