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FreeZone® Benchtop and Console
Freeze Dry Systems

Models
7750000

7751000

7750001

7751001

7750003

7751003

7750004

7751004

User’s Manual

LABCONCO CORPORATION
8811 PROSPECT AVENUE
KANSAS CITY, MO 64132-2696
800-821-5525, 816-333-8811
FAX 816-363-0130
E-MAIL [email protected]
HOME PAGE www.labconco.com

Labconco’s Mascot,

Labby the LABster

Register your product online at

www.labconco.com/productreg.html

or return the attached card and 

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FREE LabbyWear

™

!

Summary of Contents for FreeZone 7750000

Page 1: ...anual LABCONCO CORPORATION 8811 PROSPECT AVENUE KANSAS CITY MO 64132 2696 800 821 5525 816 333 8811 FAX 816 363 0130 E MAIL labconco labconco com HOME PAGE www labconco com Labconco s Mascot Labby the...

Page 2: ...Product designs are subject to change without notice 2002 Labconco Corporation Printed in U S A...

Page 3: ...who sold you the product If the cause is determined to be a manufacturing fault the dealer or Labconco Corporation will repair or replace all defective parts to restore the unit to operation Under no...

Page 4: ...rements 10 Vacuum Pump Requirements 10 Space Requirements 11 Your Next Step 11 CHAPTER 3 GETTING STARTED 13 Unpacking Your Freeze Dryer 14 Freeze Dryer Components 14 Setting Up Your Freeze Dryer 15 Co...

Page 5: ...NG 37 Vacuum Pump 37 Gaskets Tubing Connections Sample Valves 38 System Components Collection Chamber Isolation 40 Refrigeration Module Operation 42 APPENDIX A FREEZE DRYER COMPONENTS 43 APPENDIX B FR...

Page 6: ...dependable service Freeze Dry Process Dehydration is an important process for the preservation and storage of biologicals pharmaceuticals and foods Of the various methods of dehydration freeze drying...

Page 7: ...ater vapor into ice Freeze Dry Rates The efficiency of the freeze drying process is dependent upon the surface area and the thickness of the sample the collector temperature and vacuum obtained the eu...

Page 8: ...e dry flask should be two to three times the volume of the sample In order for lyophilization to occur ice must be removed from the frozen sample via sublimation This is accomplished by the collector...

Page 9: ...hese factors the eutectic temperature is the most important factor in determining the amount of sample that can be freeze dried at one time particularly when flasks are used This is because as the eut...

Page 10: ...e substances will have a greater tendency to melt particularly when placed in flasks or exposed to room temperature If a sample containing a volatile substance tends to melt when placed on a freeze dr...

Page 11: ...how to attach a recorder or computer for monitoring the operation Chapter 7 Troubleshooting contains a table of problems you may encounter while using your Freeze Dryer including the probable causes o...

Page 12: ...in injury to the user or permanent damage to your Freeze Dryer Important information is presented in capitalized type in paragraphs that are preceded by the pointer icon It is imperative that the inf...

Page 13: ...8 Product Service Domestic 1 800 522 7658 International 816 333 8811 Chapter 1 Introduction Refer to Chapter 7 Troubleshooting if you are experiencing problems with your Freeze Dryer...

Page 14: ...he location where you intend to install your Freeze Dryer You must be certain that the area is level and of solid construction An electrical source must be located near the installation site Carefully...

Page 15: ...ocation Requirements The Freeze Dryer should be located in an area that provides an unobstructed flow of air around the cabinet This air cools the refrigeration system The refrigeration system draws a...

Page 16: ...ill allow the vacuum pump to be plugged into the receptacle on the back of the Freeze Dryer See Appendix D Freeze Dryer Accessories for vacuum pumps available from Labconco Space Requirements Refer to...

Page 17: ...12 Product Service Domestic 1 800 522 7658 International 816 333 8811 Chapter 2 Prerequisites...

Page 18: ...ck and move your Freeze Dryer set up your Freeze Dryer connect the electrical supply source to your Freeze Dryer properly exhaust your Freeze Dryer safely use solvents with your Freeze Dryer The Bench...

Page 19: ...YOU MUST FILE A CLAIM DIRECTLY WITH THE FREIGHT CARRIER LABCONCO CORPORATION AND ITS DEALERS ARE NOT RESPONSIBLE FOR SHIPPING DAMAGE Do not discard the carton or packing material for your Freeze Dryer...

Page 20: ...V 7646000 Tubing 1967600 Clamps 2 1291000 Plug 230V IEC 320 230V Models only If you did not receive one or more of the components listed for your Freeze Dryer or if any of the components are damaged c...

Page 21: ...on the floor of the cabinet Connect the vacuum pump power cord to the receptacle on the back of the cabinet If the vacuum pump has an off on switch turn the switch on The vacuum pump will be controlle...

Page 22: ...inside the chamber are made of stainless steel which can be attacked by acids Use of acids can result in degradation of the product and the vacuum pump Use care when using aggressive liquids which can...

Page 23: ...your Freeze Dryer is now complete To learn how to load and operate your Freeze Dryer proceed to Chapter 4 Using Your Freeze Dryer To perform additional diagnostics on your Freeze Dryer proceed to Cha...

Page 24: ...ed in Chapter 3 Getting Started you are ready to begin using your Freeze Dryer Read this chapter to learn how to operate the controls understand the display connect samples Do not use the Freeze Dryer...

Page 25: ...mBar and collector temperature C Displays type of alarm when an alarm has occurred 3 Menu Switch This switch is used to change the display from system parameters to alarm messages 4 Vacuum Graph Disp...

Page 26: ...am 7 Auto Mode Annunciator When lit the green LED indicates that the Freeze Dryer is in the Auto Mode In this mode the vacuum pump will start when the collector temperature reaches 40 C 8 Auto Mode Sw...

Page 27: ...to remove any dirt and contaminants that could cause a vacuum leak Vacuum grease is not required on the lid gasket to obtain a proper vacuum seal 4 Inspect each sample valve and check for any visible...

Page 28: ...l temperature of the collector When the vacuum in the system is above 2000 x 10 3 mBar the vacuum display will indicate HI At 2000 x 10 3 mBar and below the display will show the actual vacuum When th...

Page 29: ...pules and serum bottles may be frozen in a freezer The sample container size should always be at least two to three times the sample size i e 150 ml samples should be prepared in 300 ml containers or...

Page 30: ...e sample container and no cold spots can be detected by handling the container the sample is nearly dry To be certain of low final moisture content dry the sample for several hours past this point 5 T...

Page 31: ...ator will flash The display will continue to show the operating parameters of the system Press MENU to display the alarm POWER FAIL Pressing MENU multiple times will identify other alarms if they have...

Page 32: ...pears This will reset the 1000 hour timer It may be necessary to service the vacuum pump more frequently than every 1000 hours depending on the operation of the freeze dryer The pump oil should be reg...

Page 33: ...he collector chamber with water and wipe chamber dry 3 If rapid defrost is desired pour warm water over the collector coil Do not fill the chamber above the collector coil as water will enter the vacu...

Page 34: ...or chamois and a mild non abrasive soap or detergent 3 Check oil level of the vacuum pump It should be between MIN and MAX If the oil level is less than an inch 25 4 mm above MIN add oil to proper lev...

Page 35: ...th sponge or chamois and a mild non abrasive soap or detergent clean the acrylic chamber lid 3 Using a soft cloth sponge or chamois and a mild non abrasive soap or detergent clean the exterior surface...

Page 36: ...Freeze Dryer interpret the data received Recorder Jack Pin Configuration The system vacuum and collector temperature can be recorded during operation by connecting an appropriate device to the record...

Page 37: ...or connection cable configuration Either of these cables can be purchased from Labconco as an accessory The part numbers for these cables are listed with the following schematics and are also listed i...

Page 38: ...bit 4 No parity is transmitted 5 Standard ASCII character set The format of the transmitted message is as follows COLLCTR 48 indicates the temperature of the collector in degrees Celsius VAC 0018 indi...

Page 39: ...mputer with Hyper Terminal software included with Windows 95 98 2000 operating systems to collect the RS232 data from your freeze dryer 1 Make sure that the Freeze Dryer is properly connected to the c...

Page 40: ...6 Using the Recorder Jack 4 The Connect To dialogue box will open Using the down arrow selection button select the communication port to which the cable has been connected Press OK 5 The Com X Propert...

Page 41: ...oduct Service Domestic 1 800 522 7658 International 816 333 8811 Chapter 6 Using the Recorder Jack 6 When the Freeze Dryer main power switch is on the data will be transmitted and updated every ten se...

Page 42: ...ory vacuum perform the following maintenance tests I Vacuum Pump First make sure that the vacuum pump operates If it fails to operate check the electrical connections of the Freeze Dryer to the power...

Page 43: ...um reading obtained Confirm that the pump is capable of achieving an ultimate vacuum less than 10 x 10 3 mBar or approximately 10 microns If an inadequate vacuum reading is obtained the pump has most...

Page 44: ...luctuations can indicate a potential vacuum leak If the valve seems to be in good condition remove the valve and apply vacuum grease and reinstall the valve DO NOT APPLY VACUUM GREASE TO THE GASKETS O...

Page 45: ...move the screw from the center of the vacuum tube cover and slide the cover off 2 Take a 3 or 4 inch piece of vacuum hose and place it over the vacuum tube Stopper and clamp the vacuum hose to the tub...

Page 46: ...amber Replace the collection chamber lid and turn on the vacuum pump Allow the vacuum pump to run for approximately 5 to 10 seconds If the vacuum pump is left on the water will begin to boil and the t...

Page 47: ...ubbling was observed on the chamber surface the chamber must be replaced This type of leak cannot be successfully repaired The leading cause of a chamber surface leak is corrosive residue left in the...

Page 48: ...PP PE EN ND DI IX X A A F FR RE EE EZ ZE E D DR RY YE ER R C CO OM MP PO ON NE EN NT TS S The following pages list components that are available for your Freeze Dryer The parts shown are the most com...

Page 49: ...ration 9 1 1289100 Relay Vacuum 10 1 1302300 Switch 11 1 7518800 Control Panel Label 12 1 1229300 Power Inlet Connector 13 1 1289320 Circuit Breaker 20 Amp 115V 13A 2 1289312 Circuit Breaker 12 Amp 23...

Page 50: ...45 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix A Freeze Dryer Components...

Page 51: ...y Refrigeration 9 1 1289100 Relay Vacuum 10 1 1302300 Switch 11 1 7518900 Control Panel Label 12 1 1229300 Power Inlet Connector 13 1 1289320 Circuit Breaker 20 Amp 115V 13A 2 1289312 Circuit Breaker...

Page 52: ...47 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix A Freeze Dryer Components...

Page 53: ...48 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix A Freeze Dryer Components...

Page 54: ...Product Service Domestic 1 800 522 7658 International 816 333 8811 A AP PP PE EN ND DI IX X B B F FR RE EE EZ ZE E D DR RY YE ER R D DI IM ME EN NS SI IO ON NS S 77500 SERIES FREEZONE 4 5 LITER BENCHT...

Page 55: ...50 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix B Freeze Dryer Dimensions 77510 SERIES FREEZONE 4 5 LITER CONSOLE...

Page 56: ...ironmental operating conditions and wiring diagrams Electrical Specifications Nominal Voltage Models 7750000 7750003 7751000 7751003 115 Volt Models 7750001 7751001 220 240 Volt Models 7750004 7751004...

Page 57: ...ty at 104 F 40 C Main supply voltage fluctuations not to exceed 10 of the nominal voltage Transient overvoltages according to Installation Categories II Overvoltage Categories per IEC 1010 Temporary v...

Page 58: ...53 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix C Freeze Dryer Specifications Wiring Diagram 115V 60 Hz Models...

Page 59: ...54 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix C Freeze Dryer Specifications Wiring Diagram 230V 50 or 60 Hz Models...

Page 60: ...single phase 7 8 amps Includes Pump Exhaust Filter 1473400 7739403 Vacuum Pump Two stage direct drive pump 195 liters minute 230 VAC 50 60 Hz single phase 4 0 amps with reverse IEC plug Includes Pump...

Page 61: ...mps 1473200 Replacement Element Oil Mist Pump Exhaust Filter 1473300 Replacement Element Odor Pump Exhaust Filter package of 5 1988000 Vacuum Pump Oil 1 Liter 7772000 Soda Acid Trap Secondary trap tha...

Page 62: ...304 stainless steel with 12 freeze dry valves 7522900 16 Port Chamber 13 high x 138 diameter 304 stainless steel with 16 freeze dry valves 7867000 Clear Drying Chamber 13 high x 13 diameter clear acry...

Page 63: ...V 7509400 Product Heater with Variable Heat For use in chamber 7522900 Provides variable heat up to 43 C 110 F 115V 7509401 Product Heater with Variable Heat For use in chamber 7522900 Provides variab...

Page 64: ...for glassware attached to the collection chamber 7509600 Sample Valve Kit Includes Neoprene valve body knob and installation parts 7534000 Cable Connects the RS 232 output from the Freeze Dryer or Fre...

Page 65: ...asily inserted between the adapter and top of the flask One hun dred filters are sup plied with each flask Compatible with all major brands of laboratory freeze dry apparatus Wide mouth opening loads...

Page 66: ...ne rubber seal grasps top and bottom The flexible ring holds securely together during pre freezing and lyophiliza tion Compatible with all major brands of labo ratory freeze dry apparatus Flat bottom...

Page 67: ...wall construction ensures even freezing and drying Bottles and vials are ideal containers for use in the FreeZone Stoppering Tray Dryer Serum bottles also connect to valve ports on drying chambers an...

Page 68: ...d Stoppering Flat Bottom Bottom 1 ml 7572710 7570010 7570610 2 ml 7570810 7572310 4 ml 7572810 5 ml 7570210 7571010 10 ml 7571210 7571610 25 ml 7571810 50 ml 7572010 Ampule Valve Adapters 7593401 Adap...

Page 69: ...64 Product Service Domestic 1 800 522 7658 International 816 333 8811 Appendix D Freeze Dryer Accessories...

Page 70: ...65 Product Service Domestic 1 800 522 7658 International 816 333 8811...

Page 71: ...are engaged Quality Control Teaching Instructional Testing Other please specify Clinical Diagnostic Research Development Production _______________________________ Of what type organization is your wo...

Page 72: ...collect Labby Bucks and redeem for other LabbyWear merchandise Then just complete the information requested on the reverse side fold tape edges and mail LabbyWear is the official uniform of LABsters e...

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