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4.4.7 Suppositories
We recommend using the UNGUATOR® Disp. Blade for up to 200 ml.
The heating of fat suppository base ointment may be carried out using an infrared lamp
over the open UNGUATOR® Jar. An UNGUATOR® Applicator aids the precise filling of
the suppository forms. It may be reheated using a hair dryer or an infrared lamp. A batch
of approximately 5 to 10% is recommended.
4.4.8 Powder
(Mixing powder to fill capsules).
We recommend using the UNGUATOR® Disp. Blade for sizes up to 200 ml.
Excellent mixing results will be achieved when using microfine powder with a high content
of lubricious aerosil, which is considered as “Soft in Soft” (S/S) preparation. Please select
low rpm (level 0/650 rpm), preferably applying the manual “Hand” mode (changing from
“Auto” to “Hand”). Please have the mixing time extended accordingly.
4.5 Requirements for the ingredients of a prescription
Powder
If possible powders should be used as microfine substances. Powders should be added
after any liquid constituents to ensure better wetting. For substances with a low proportion
of powder, we recommend pregrinding by pasting the powder in minimum base inside the
UNGUATOR® Jar, as already described before.
Crystalline Active Ingredients
We recommend pulverizing active crystalline ingredients in a mortar prior adding into the
UNGUATOR® Jar.
Should a solvent for the active crystalline ingredient be part of the formulation, the
ingredients may then also be dissolved in the UNGUATOR® Jar. For example, urea with
water. Then the remaining formulation ingredients can be added. The crystalline substance
may also dissolve during the mixing process if the solvent is an ingredient of the ointment
base.
