Franklin HAD-3038, User Manual

Page: 6 / 22

4
of drugs and their CYP450 isoforms is available
on the internet at www.drug-interactions.com.
These isozymes are named according to a stan-
dard system, e.g. CYP3A4 or P4503A4. Drugs
that are substrates or inhibitors for the same
isozyme in vitro are likely to interact, but no inter-
action may be detectable, or it may not be clini-
cally significant. Other drugs alter the binding of
another drug to plasma proteins or tissue recep-
tors, alter the distribution of drugs to active recep-
tor sites, delay or enhance excretion, or cause
additive or synergistic effects.
Elimination of a drug can also be affected by the
P-glycoprotein membrane-bound transport sys-
tem. Digoxin, for example, moves across cell
membranes by a P-glycoprotein controlled pro-
cess. Drugs such as quinidine that inhibit P-glyco-
protein activity, can increase the serum
concentration and toxicity of digoxin.
RECOMMENDATIONS — Monitoring is
most important when one of the interacting drugs
is stopped or started. Some experienced clinicians
may prefer to monitor the patient’s clinical status
rather than follow serum concentrations of drugs.
Concurrent use of drugs from the same group,
e.g., aspirin and other NSAIDs, should be
avoided.
Introduction to the HADI
Key Guide
Color Keys
MORE
(
red
) Displays interactions between
selected drug(s) and all other drugs
in this book.
SPEC
(
green
) Displays a glossary entry.
SEARCH
(
yellow
) Searches for interactions
among the selected drugs.
LIST
(
blue
) Lists the items currently se-
lected from the main drug list.
Function Keys
BACK
Erases typed letters, or backs up to
the previous screen.
CAP
Shifts keys to type capitals or punctuation.
CARD
Exits the currently selected book.
CLEAR
Clears your search and returns to
the main drug list.
ENTER
Enters a word, selects a menu item,
or starts the highlight in text.
HELP
Displays help messages.
MENU
Displays the main menus.
ON/OFF
Turns the platform on or off.
SPACE
At menus and text, pages down. At
entry screens, types a space.
?
✻
At menus, displays the title of a high-
lighted item. At text, displays the current
entry title. With
CAP
, types an asterisk
(
✽
) to stand for letters in a word.