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Argonaut Quest 210, User Manual

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Argonaut Quest 210 User Manual Download Page 72

Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com

Summary of Contents for Quest 210

Page 1: ...service in house repair center WE BUY USED EQUIPMENT Sell your excess underutilized and idle used equipment We also offer credit for buy backs and trade ins www artisantg com WeBuyEquipment REMOTE IN...

Page 2: ...User Manual Quest 210 Manual Synthesizer part number 900114 Rev 3 ARGONAUT TECHNOLOGIES Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 3: ...Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 4: ...210 Maintenance Troubleshooting To be supplied Appendix A Glossary of Terms Appendix B Control Box Display Screens Appendix C Quest Plumbing Schematic ARGONAUT TECHNOLOGIES Artisan Technology Group Q...

Page 5: ...Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 6: ...210 provides step by step instructionsforperformingsolidphase or solutionphase reactions on the Quest 210 Chapter 4 Maintenance provides step by step instructions on maintenance procedures for optimum...

Page 7: ...t teflon Proprietary vertical oscillation mechanism 40 C to 130 C requiresrecirculating chiller for temperature control below ambient Accommodates 20 and 40 mL scintillation vials 13 x 100rnrn 20 x 12...

Page 8: ...the right is to warn of hot surface Use caution when working near or on the Reactor Assembly Allow it to cool before attempting to access RVs This symbol indicates a shock hazard Use care when working...

Page 9: ...30 40 psi house nitrogen supply or other inert gas 110VAC line supply for the Quest Controller Unit The Quest will also operate on 90 240 VAC without any modification required User supplied chiller So...

Page 10: ...no chargeprovidedthat Argonaut is notifiedof defectswithin the warranty period The following Quest 210 systems and options are protected by this warranty Reactor Assembly Controller Automated Solvent...

Page 11: ...aintenance as specified in the user operation manual 4 Non conformance to recommended instrument operation procedures 5 Any product on which the serial number has been defaced modified or removed 6 An...

Page 12: ...location Contact your local Argonaut representative for pricing of installation services by a qualified Argonaut Service Engineer After installation it is the responsibility of the customer to retain...

Page 13: ...erence will not occur in a particular installation If this equipment does cause interference to radio or television reception which can be determined by turning the equipment off and on the user is en...

Page 14: ...l at the right is to warn of hot surface Use caution when working near or on the Reactor Assembly Allow it to cool before attemptingto access RVs This symbol indicates a shock hazard Use care when wor...

Page 15: ...side California FAX 650 598 1359 In Europe Argonaut Technologies A G St Jakobsstrasse 148 Postfach 43 4132Muttenz 2 Switzerland PHONE 41 61 465 9898 FAX 41 61 465 9899 In Japan Argonaut Technologies K...

Page 16: ...epartment at Argonaut Technologies should be contacted via e mail at support argotech comor at the number above with questions or comments on the content of this user manual This equipment has been ty...

Page 17: ...embly Umbilicus The Reactor Unit contains Teflon reaction vessels manual solvent and gas control valves and heating cooling and agitation components Solvents can be added to the RVs in parallel using...

Page 18: ...ion vessels Metered Gas provides a pathway for 10psi gas to move from the Controller Unit to the reactor assembly The metered gas line provides an adjustable gas flow to the reaction vessel providing...

Page 19: ...for gas and liquid connec tions Semi rigid Tygon Tubing This flexible tubing has a slight yellow color to it Used for gas connections within the Quest controller unit Bushing The tan colored threaded...

Page 20: ...trument and place the Quest Reaction Unit in the hood and the Quest Controller on the lab bench next to the hood Remove any packaging material from the units The umbilicus will be connectedto the Ques...

Page 21: ...Introduction Quest Installation Procedure Figure 1 2 Quest Controller Unit UmbilicusConnections Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 22: ...1 3 Quest Reactor Unit installation Procedure QUEST 210 User Manual ain Port ons Poa Ins Ier Man1 Levers r Manifc Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisan...

Page 23: ...bound bushing from a ferrule grasp the ferrule between the thumb and index finger and gently rock the bushing back to free it Connect the tubes labeled 1 2 3 4 and 5 to the matching female threaded po...

Page 24: ...fumes will escape through the tube connectedto the Vent Port of the SolventBottle Cap Point thistube towardsthe rear of the fume hood or tape it down to a convenientspot in the fume hood Connect the R...

Page 25: ...tings to a set of 3 female fittings located on the Quest Upper Manifold assembly These latter fittings are located in a canted triangle configuration on the Quest Upper Manifold Assembly see diagrams...

Page 26: ...anifold located at the top of the triangle of ports see diagram previous page Screw in the bushing for one end of the tube labeled Man Vent to the red bulk head fitting located on the upper Reactor As...

Page 27: ...eactor Assembly grasp the handles on the lower Waste Tray Press the buttons on the handles and move the tray to its lowest position Carefully place the Glass Tank on the tray and raise the tray back t...

Page 28: ...ip if desired 10A minimum rating Turn on the power to the Quest using the switch on the left rear of the unit Install a 4L Solvent Bottle Place a 4L bottle in a safety carrier on the lab bench Install...

Page 29: ...Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 30: ...You set the reaction temperature heating duration and agitation by means of the control box display screens and buttons The parameters that you set on the display screens are executed by means of the...

Page 31: ...on solutions Mix the reaction solutions Control the solvent and gas flow in the reactor assembly thereby performing manual solvent addition to the reaction vessels draining of solution from the reacti...

Page 32: ...s Frit The frit is a teflon filter that is installed in the bottom of each reaction vessel The frit allows for draining of solution from the reaction vessels while containing the solid support resin w...

Page 33: ...e Controller Unit alternatively supply 30 psi gas to the bottom and top of the gas cylinder moving the piston and magnet bar up and down respectively The velocity of the oscillatingvertical mixing str...

Page 34: ...tted portion of each pathway is Teflon Each pathway has a common channel and inlets to each reaction vessel The common channels also connect to the Manifold Control Valves so that the source liquid or...

Page 35: ...atmosphere to the RVs and to provide a lower pressure drain gas for product collection into vials The flow rate of the metered gas can be controlled via a needle valve located at the top of the Quest...

Page 36: ...Valve to increase or decrease the gas flow rate To decrease the flow rate turn the Metered Gas Needle Valve clockwise To increase the flow rate turn the Metered Gas Needle Valve counterclockwise The...

Page 37: ...tle cap dial is in the pressure position 8 psi gas flows from the control box into the solvent bottle by means of the pressure line WARNING Always place the 4 L solvent bottle in the plastic Safety Ca...

Page 38: ...Vessel Waste Draining Lower Manifold Drain Valves The drain valves are located on the lower manifold and mechanically seal the lower exit paths from the reaction vessels Each drain valve has a lever...

Page 39: ...h the container installed move the tray to its upper notch position to lock the container in place just below the Lower Manifold Sample Collection When it is time to collect reaction products from the...

Page 40: ...y and stroke duration Connections for the system gas pressure and electrical power Other components of the Controller Unit include agitation control valves agitation speed needle valve gas pressure re...

Page 41: ...Firmware Version Screen shows the Quest 210 firmware version number Agitation Control Screen allowsyou to set the agitation parameters You can set three agitation parameters on this screen MixEverysec...

Page 42: ...cular display screen see Appendix B Control Box Display Screens Forward and Back Buttons The Forward and Back buttons allow you to select a parameter on the display screen Press the Forward right butt...

Page 43: ...r most button causes the agitator bar to move to and stay in the up position The lower button causes the agitator bar to move to and stay in the down position The middle button causes the agitator bar...

Page 44: ...s line from the Contoller Unit to the Reactor Unit Metered Gas The drain gas port supplies 10psi gas line from the Contoller Unit to the Reactor Unit and is flow regulated by a needle valve on the Rea...

Page 45: ...Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 46: ...n the Quest 210 Preparing the Quest for a Synthesis 1 The Quest Reactor Unit should be placed in a fume hood 2 The Controller Unit should be placed outside of the fume hood and away from chemical haza...

Page 47: ...position at the top of the Quest Reactor Unit 3 Using the red handledpliers removaltool graspthe top of the reaction vessel and twist up using the reactionvesselholder as a fulcrum tobreak the reactio...

Page 48: ...t as a fulcrum twist the vessel to breakit from the Lower Manifoldmale fitting Figure 3 3 The reactionvessel is free from the Lower Manifold male fitting QUEST 210 User Manual Artisan Technology Group...

Page 49: ...e A and Side B Each side contains a bank of 10 reaction vessels You can use either side or both sides simultaneouslyfor synthesis If less than 10 reactions are to be run on a particular side place emp...

Page 50: ...0 mg of ArgoGel or similar gel type resin can be used in the 5 ml vessels 3 With a soft cloth and appropriate solvent clean the male reaction vessel fittings on the Upper and Lower Manifolds Ensure th...

Page 51: ...Reactionvessel and installationtool 7 Press down on the Insertion Tool to set the reaction vessel over the male fitting of the lower manifold Artisan Technology Group Quality Instrumentation Guarante...

Page 52: ...3 6 Press the vessel into place 8 Repeat this procedure for each vessel Figure3 7 Proper installation of the reaction vessels QUEST 210 User Manual Artisan Technology Group Quality Instrumentation Gua...

Page 53: ...ht down onto the levers 10 Adjust the Agitation Stops to the appropriate height Typically the maximum magnet stroke height should be below the level of the reaction solution a The lower stop sets the...

Page 54: ...ner under the Reactor Unit This container can be removed for product collection Place the glass waste container the Waste Tray Next via buttons on its handle move the tray to its upper notch position...

Page 55: ...solvent additions Manually adding reagents or solvents to the reaction vessels through the luer ports Determine the steps that you wish to use to complete a liquid or solid phase chemistry reaction th...

Page 56: ...l Addition of Solvents for instructions Set the Agitation Parameters NOTE Set the agitation parameters to minimize splashingof solution on the upper manifoldmale fittings This will prevent build up of...

Page 57: ...ond to the UpStroke parameter Likewise if you change the Upward parameter then the Upstroke parameter will change automatically to correspond to the 9 Upward parameter To change the Upstrokeparameter...

Page 58: ...ke t12 H Upstroke J Time t 2t 3t MIX Every S ec Agitation Parameter Considerations When setting the agitation parameters considering these guidelines If the reaction solutionis viscous or a large amou...

Page 59: ...required When using the chiller only connect it to one side of the Quest at a time WARNING When heating the Reactor Assembly will become hot The symbol at the right is to warn of hot surface Use caut...

Page 60: ...ons to increase or decrease the chosen time parameter WARNING As a general rule do not enter a temperatureset point above the boiling point of the reactionsolventbeing used This prevents against over...

Page 61: ...Monitor screen This screen will display the set point and the actual RV temperature Chilling the Reaction Vessels For sub ambient temperature set points an external recirculating chiller is required S...

Page 62: ...ation Connect the chiller return hose to the 114 female pipe brass fitting on the right of the reaction vessel bank Ensure that the chiller hoses and Brass fittings are equipped with foam insulation I...

Page 63: ...inert gas blanket Parallel Solvent Addition and Vessel Draining Parallel Solvent Addition The Quest system is equipped with an external bottle cap assembly which can interface to a standard 4L solven...

Page 64: ...utility 1 metered gas vent 0closed utility 2 4 When the reaction vessels have been filled to the desired level rotate the left hand Manifold Control Valve from solvent to drain as this will blow resid...

Page 65: ...Operatingthe Quest 210 Starting a Reaction drain solvent closed utility 1 metered gas vent 0closed utility 2 Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 66: ...sed utility 2 4 Open the drain valves on the lower manifold To open the valves individually Push down on the drain valve lever to drain the reaction vessel Return the lever to the closed up position w...

Page 67: ...ttle cap turn the dial to the Vent position Wait 1minute for the bottle to vent before proceeding 4 For the side of the Quest with the reaction vessels installed vent the reaction vessels by setting t...

Page 68: ...ter clockwise Leave the valves in that configuration for 1 minute to completely empty the line drain solvent 0closed utility 1 metered gas vent 0closed utility 2 7 Turn both Manifold Control Valves to...

Page 69: ...er placing the ManifoldControl Valve to the Vent position slowly remove the her plug by rotating the plug as it is pulled back WARNING The reaction vessel contents may be under pressure Wear safety gl...

Page 70: ...red gas vent 0closed utility 2 It is recommended to attach a Teflon Vent tube Found in the accessory kit or oil bubbler to the Utility 1port with the outlet pointed away from the Quest towards the bac...

Page 71: ...es NOTE For product collection use the 10psi Metered Gas as opposed to the 30 psi Drain Gas to provide the head pressure for fluid transfer Using the higher pressure can result in splashing Collection...

Page 72: ...move the Glass Collection Tank and drain its contents to an appropriate storage container 4 Place the desired collection rack and vials on the waste collection tray 5 Set the Manifold Control Valves a...

Page 73: ...Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 74: ...n valves still open turn off the Drain gas set valve to Closed and turn on the MeteredGas This will flush out the other common channel of the Upper Manifold Placeeach ManifoldControlValve to the Close...

Page 75: ...ction vessel fittings 7 Empty the glass rectangular tank and rinse clean Do not leave the tank full of waste liquid when the system is not in use Examine the plastic plate located above the waste tank...

Page 76: ...5 Troubleshooting To be provided QUEST 210 User Manual Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 77: ...Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 78: ...test tube into which you can collect synthesis product Controller Unit This unit contains and LCD screen and keypad through which agita tion and temperature parameters are set and controlled Drain Gas...

Page 79: ...nit to the Reactor Unit and is flow regulated by a needle valve on the Reactor Unit Metered Gas Needle Valve A control knob that increases or decreases the flow rate of 10psi gas into the reaction ves...

Page 80: ...lines are teed with tubes going to the corresponding Manifold Control Valves on each side of the Quest Waste Container A rectangular glass container for waste collection The glass waste container is...

Page 81: ...Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 82: ...the aid of the control box buttons allow you to change the reaction temperature time and agitation frequency This appendix lists the various display screens and explains how to use the control box bu...

Page 83: ...Appendix B Control Box Display Screens Figure 2 1 Quest Controller Box and LCD Display Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 84: ...hnologies Quest 210 Table 2 1 Sign on Screen Control Button Functions I Firmware Version screen Pressingthis button I PARAMETER INIA Resultsin STARTISTOP STARTISTOPHeaters screen appearing IStartsISto...

Page 85: ...uest 210 revision and the revision date Figure 2 1 Firmware Version Screen Control Button Functions MODE I Agitation Control screen appearing Pressingthis button PARAMETER INIA Resultsin AGITATOR ON I...

Page 86: ...is necessarily less than the agitation frequency value The Upward parameter controls the upstroke in the same manner as the Upstroke parameter but is expressed in terms of a percentage of the agitatio...

Page 87: ...l Screen Control Button Functions ISet Temperature screen appearing Pressingthis button Resultsin ISTARTISTOPHeaters screen appearing FORWARD BACK PARAMETER IStartsIStopsagitation selecting a paramete...

Page 88: ...essel size Table 2 3 Set Temperature Screen Control Button Functions STARTISTOP QUEST 210 User Manual Monitor Temperature screen selecting a parameter on the screen increasing or decreasing the value...

Page 89: ...which you set reactions the actual temperature at which the reaction is and whether the heaters are on or off Table 2 4 Monitor Temperature Control Button Functions PARAMETER PARAMETER STARTISTOP Othe...

Page 90: ...nctions can be seen on the screen at one time however if you continue to press the Forward button when you reach the bottom of the screen the screen will scroll up so you can see the other choices The...

Page 91: ...cursor will be engaged Pressingthis button Moves the cursor up or down to select one of the 5 screen options Resultsin Moves the cursor up or down to select one of the 5 screen options STARTISTOP IST...

Page 92: ...Return to the Other Functions Screen Pressingthis button ERWARDIBACK Iincreasing or deceasing the display screen contrast Resutts in PARAMETER F c r e a s i n g or deceasing the display screen contras...

Page 93: ...s complete the Selftest screen remains displayed until you press the Mode button Results are displayed as follows For the AD thermocouple and transformer tests either OK ERR or is displayed means that...

Page 94: ...eturn to the Other Functions Screen Pressingthis button STARTISTOP ISTARTISTOPHeaters screen appears Results in AGITATOR ON IStarts Stops agitation QUEST 210 User Manual Artisan Technology Group Quali...

Page 95: ...CD display contrast etc to be reset to their factory preset default values User settings are stored in a battery backed up memory so that if you turn the unit off you do not need to re enter everythin...

Page 96: ...sen option See this section for a definition of the Forward and Back buttons and the STARTISTOPbutton Table 2 8 STARTISTOPControl Button Functions MODE IReturns to previous screen Pressingthis button...

Page 97: ...Appendix C QUEST 210Plumbing Schematic Artisan Technology Group Quality Instrumentation Guaranteed 888 88 SOURCE www artisantg com...

Page 98: ...service in house repair center WE BUY USED EQUIPMENT Sell your excess underutilized and idle used equipment We also offer credit for buy backs and trade ins www artisantg com WeBuyEquipment REMOTE IN...

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