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Multimode Source for 6410 Triple Quad LC/MS User Guide
3
Reference
Guidelines
Guidelines
Guidelines for multimode source settings in MM-ES mode
Nebulizer pressure
Always set to 60 psi.
Drying gas flow
Always set to 5 L/min (IR does the drying).
Drying gas temperature
Depends on the vaporizer temperature. A good
starting temperature is 250°C. If running a cold vaporizer temperature, then
set the drying gas temperature to vapor temperature or lower. If running the
vaporizer hot (>175°C), then set the drying gas temperature to 350°C.
Remember you want the vaporizer to control the drying and to be able to
maintain the set point.
Vaporizer
Start at 150°C. ESI works across a broad vaporizer range. If you are
getting excessive sodium adducts, lower the temperature. You can run as low
as 60°C. It is recommend to run 100°C or greater. Negative ion TFA adducts
work best at lower temperature (<150°C).
Vcap
Set to 2000 V. High mass ions (>1000) prefer a higher Vcap.
Charging Voltage
Set to 200 V.
