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Atmospheric Pressure

GC

Operator’s Guide Supplement

Revision F

Copyright © Waters Corporation 2010–2012

All rights reserved

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Содержание APGC

Страница 1: ...Atmospheric Pressure GC Operator s Guide Supplement Revision F Copyright Waters Corporation 2010 2012 All rights reserved...

Страница 2: ...ility for any errors that may appear in this document This document is believed to be complete and accurate at the time of publication In no event shall Waters Corporation be liable for incidental or...

Страница 3: ...ting Waters Contact Waters with enhancement requests or technical questions regarding the use transportation removal or disposal of any Waters product You can reach us via the Internet telephone or co...

Страница 4: ...ractice and consult your organization s safety representative for guidance Considerations specific to the Atmospheric Pressure GC High temperature hazard See also The relevant Agilent 7890 GC user doc...

Страница 5: ...ethod of decontamination to be used and the appropriate protection for personnel undertaking the decontamination process You must handle items such as syringes fused silica lines and borosilicate tips...

Страница 6: ...t to the atmospheric pressure ionization API source on compatible LCMS instruments The APGC is for research use only It is not intended for use in diagnostic applications It is intended for use only b...

Страница 7: ...normal and above normal levels of a compound Ensure that QC sample results fall within an acceptable range and evaluate precision from day to day and run to run Data collected when QC samples are out...

Страница 8: ...viii EC authorized representative Waters Corporation Micromass UK Ltd Floats Road Wythenshawe Manchester M23 9LZ United Kingdom Telephone 44 161 946 2400 Fax 44 161 946 2480 Contact Quality manager...

Страница 9: ...cable symbols vi Audience and purpose vi Intended use of the APGC vi Calibrating vii Quality control vii ISM classification vii ISM Classification ISM Group 1 Class A vii EC authorized representative...

Страница 10: ...ometer 2 16 Disconnecting the APGC from the mass spectrometer 2 17 Removing vials from the vial carriers 2 18 Preparing the mass spectrometer for LC operation 2 19 Removing the APGC vial carriers from...

Страница 11: ...Warnings that apply to all Waters instruments A 6 Electrical and handling symbols A 11 Electrical symbols A 11 Handling symbols A 12 B Installing the GC Column B 1 C Preparing Sample Vials C 1 Prepari...

Страница 12: ...xii Table of Contents...

Страница 13: ...nt GC with a compatible Waters LCMS instrument Doing so makes possible performing LC and GC analyses in the same system without compromising performance It also avoids the need for separate dedicated...

Страница 14: ...polarity The APGC is compatible with these Waters LCMS instruments Xevo TQ MS Xevo TQ S Xevo TQD Xevo QTof MS Xevo G2 QTof Xevo G2 Tof SYNAPT G2 MS SYNAPT G2 HDMS SQ Detector 2 See also The relevant i...

Страница 15: ...Waters APGC 1 3 Agilent GC and autosampler mounted on the APGC platform APGC platform Agilent 7890 GC Autosampler...

Страница 16: ...PGC main components When you operate the mass spectrometer in GCMS mode the APGC source enclosure and APGC ion chamber serve in place of the standard mass spectrometer source enclosure and cone gas no...

Страница 17: ...ents Note that the stability frame is not required with this version of the APGC APGC trolley The APGC trolley is a mobile steel cabinet on top of which the APGC is fixed in place A locking lever and...

Страница 18: ...Lift the locking lever 4 Push the locking tab toward the locking plate as far as it will go 5 Release the locking lever ensuring that the inner notch engages firmly with the locking tab 6 Adjust the...

Страница 19: ...e trolley 1 Lift the locking lever 2 Pull the locking tab outward as far as it will go 3 Drop the locking lever so that the outermost notch engages with the locking tab 4 Carefully slide the trolley a...

Страница 20: ...al use and hot gas can escape from the capillary column s tip Use the APGC protection cap to cover the tip when you withdraw the tube from the source enclosure for extended periods Warning To avoid bu...

Страница 21: ...eter s source enclosure Turning the locking ring through 180 locks the transfer line to the APGC source housing APGC source enclosure You can easily remove the APGC source enclosure and ion chamber fr...

Страница 22: ...rce ion block The unheated vial carrier is located in the bottom of the source enclosure Source internal components Warning To avoid burn injuries take great care when working with the heated vial car...

Страница 23: ...d in LC operation Requirements During APGC operation with the Xevo TQD or SQ Detector 2 mass spectrometer you must use the reduced aperture 0 36 mm sample cone supplied with the APGC to avoid problems...

Страница 24: ...1 12 Instrument Description...

Страница 25: ...on about operating the APGC Contents Topic Page Preparing the mass spectrometer for operation with the APGC 2 2 Installing vials in the vial carriers 2 14 Connecting the APGC to the mass spectrometer...

Страница 26: ...ve or maintaining the source To prepare the Xevo TQ MS Xevo TQ S Xevo TQD or SQ Detector 2 1 In the MassLynx Tune window click Standby 2 Set the source temperature to 30 C 3 Wait 30 minutes to allow t...

Страница 27: ...erface door closed Warning To avoid personal contamination with biologically hazardous toxic or corrosive materials and to avoid spreading contamination to uncontaminated surfaces wear clean chemical...

Страница 28: ...the source enclosure and lift it vertically off the two supporting studs on the source adaptor housing Removing the source enclosure 8 Store the cables neatly by plugging them into the cable storage...

Страница 29: ...sition to rotate the sampling cone assembly by 90 Rotating the sampling cone assembly Warning To avoid personal contamination with biologically hazardous toxic or corrosive materials and to avoid spre...

Страница 30: ...xtraction tool from its storage location on the source adaptor housing 5 Slide the collar to the end of the tool Preparing the cone extraction tool Caution To avoid damaging the instrument by sudden v...

Страница 31: ...o the sample cone 7 Rotate and lift the tool and collar to remove the sample cone from the cone gas nozzle Tip Store the cone gas nozzle in a safe location Removing the sample cone Caution To avoid da...

Страница 32: ...extraction tool to remove the securing screw and washers securing the upper gas cone position block to the ion block assembly and then remove the gas cone position block from the ion block assembly R...

Страница 33: ...correct sample cone for the instrument you intend to use with the APGC For Xevo TQD or SQ Detector 2 instruments use the 0 36 mm sample cone provided with the APGC The cone is labelled 0 36mm on its b...

Страница 34: ...Looking into the right hand end of the APGC ion chamber use the corona pin adjuster nut to position the corona pin tip to the edge of the small hole at the opposite end of the assembly Positioning the...

Страница 35: ...socket 8 Pull out the locking plate on the APGC ion chamber to expose the 2 captive securing screws 9 Locate the APGC ion chamber on the ion block and use the combined 2 5 mm Allen wrench and cone ext...

Страница 36: ...erials Chemical resistant powder free gloves To install the APGC source enclosure 1 Using two hands fit the source enclosure to the two supporting studs on the source adaptor housing 2 Connect the sou...

Страница 37: ...m of the APGC source enclosure push it fully to the front of the enclosure 3 Open the source isolation valve 4 Swing the source enclosure closed Vial carrier locations Warning To avoid personal contam...

Страница 38: ...ppendix C 3 Pull the APGC source enclosure release located at the bottom right hand side outwards and swing open the enclosure Warning To avoid personal contamination with biologically hazardous toxic...

Страница 39: ...You must use only closed vials when placing samples in the heated vial carrier Tips Use the unheated vial carrier for more volatile samples the heated vial carrier for less volatile samples Multiple...

Страница 40: ...ector see the figures on page 1 8 and page 1 9 Tip You sometimes must carefully maneuver these components to align the APGC locking ring and source enclosure heated transfer line connector correctly 5...

Страница 41: ...ated transfer line connector 3 Carefully move the sliding table fully away from the mass spectrometer 4 Release the locking handle to secure the sliding table 5 Fit and tighten the APGC protection cap...

Страница 42: ...tward and then swing open the enclosure 3 Use the tweezers to remove the vials from the vial carriers 4 Swing the source enclosure closed Warning To avoid personal contamination with biologically haza...

Страница 43: ...lose the source isolation valve 4 Remove the heated vial carrier from the top of the mass spectrometer s source ion block see the figure on page 1 10 5 Remove the unheated vial carrier from the bottom...

Страница 44: ...instrument 3 Using two hands grasp the source enclosure and lift it vertically off the two supporting studs on the source adaptor housing Warning To avoid personal contamination with biologically haz...

Страница 45: ...m the ion block 5 Disconnect the APGC corona pin extension cable from the corona pin mounting socket 6 Slide the sample cone with its O ring out of the left hand end of the APGC ion chamber Tip If you...

Страница 46: ...tion 1 Use the 2 5 mm combined Allen wrench and cone extraction tool to fit and tighten the screw and washers securing the upper gas cone position block to the ion block assembly see page 2 8 2 Repeat...

Страница 47: ...e cone that you retained in the previous procedure page 2 21 step 6 4 Carefully slide the sample cone including its O ring into the cone gas nozzle 5 Hold the sampling cone assembly so that the cone g...

Страница 48: ...nt s connectors Tip The cables and connectors are color coded the blue sleeved cable connects to the blue connector and the yellow sleeved cable to the yellow connector 5 Slide the instrument s source...

Страница 49: ...GC s performance Keep to a maintenance schedule and perform maintenance as required and described in this chapter Contents Topic Page Maintenance schedule 3 2 Spare parts 3 2 Safety and handling 3 3 C...

Страница 50: ...he Waters Quality Parts Locator on the Waters Web site s Services Support page Maintenance schedule Procedure Frequency For information Clean the mass spectrometer sample cone When sensitivity decreas...

Страница 51: ...and chemical properties of the solvents used see the Material Safety Data Sheets for the solvents in use Warning To avoid electric shock do not remove the instrument s panels The panels do not cover...

Страница 52: ...ails about how to clean the sample cone refer to the mass spectrometer s operator s overview and maintenance guide Cleaning or replacing the corona pin APGC ion chamber assembly APGC ion chamber body...

Страница 53: ...APGC ion chamber when removing the corona pin adjuster nut from the assembly 4 Remove the APGC ion chamber from the ion block see page 2 21 Recommendation Clean the APGC ion chamber after it has been...

Страница 54: ...you are replacing the corona pin dispose of the old pin in accordance with local environmental regulations 9 Fit the ceramic washer spring and insulator to the corona pin see the figure on page 3 4 10...

Страница 55: ...ree tissue and use it to carefully clean the ion chamber 4 Refit the APGC ion chamber onto the ion block see page 2 9 Warning To avoid personal contamination with biologically hazardous toxic or corro...

Страница 56: ...3 8 Maintenance Procedures...

Страница 57: ...es also include the hazard symbols with accompanying text statements describing the hazards and telling you how to avoid them This appendix presents all the safety symbols and statements that apply to...

Страница 58: ...electric shocks ultraviolet radiation exposures and others When the following symbols appear in a manual s narratives or procedures their accompanying text identifies the specific risk and explains ho...

Страница 59: ...tion Extinguish all nearby flames Do not use tubing that is or has been stressed or kinked Do not expose nonmetallic tubing to incompatible compounds like tetrahydrofuran THF and nitric or sulfuric ac...

Страница 60: ...al surfaces of the mass spectrometer when the instrument is in Operate mode To avoid non lethal electric shock make sure the instrument is in Standby mode before touching areas marked with this high v...

Страница 61: ...ed statement alert you to such risk Warning To avoid injury from handling biologically hazardous toxic or corrosive materials you must know the hazards associated with them Observe Good Laboratory Pra...

Страница 62: ...ler le droit de l utilisateur exploiter l quipement Achtung Jedwede nderungen oder Modifikationen an dem Ger t ohne die ausdr ckliche Genehmigung der f r die ordnungsgem e Funktionst chtigkeit verantw...

Страница 63: ...e trouvant proximit de l instrument Evitez d utiliser des tubes s v rement d form s ou endommag s Evitez d utiliser des tubes non m talliques avec du t trahydrofurane THF ou de l acide sulfurique ou n...

Страница 64: ...iamenti nei tubi non metallici riducendo notevolmente la pressione di rottura dei tubi stessi Advertencia se recomienda precauci n cuando se trabaje con tubos de pol mero sometidos a presi n El usuari...

Страница 65: ...Warnings that apply to all Waters instruments A 9 Nonmetallic Tetrahydrofuran THF Methylene chloride Dimethyl sulfoxide THF...

Страница 66: ...tueuses Vorsicht Der Benutzer wird darauf aufmerksam gemacht dass bei unsachgem er Verwenddung des Ger tes die eingebauten Sicherheitseinrichtungen unter Umst nden nicht ordnungsgem funktionieren Atte...

Страница 67: ...e can appear in instrument user manuals and on the instrument s front or rear panels Electrical power on Electrical power off Standby Direct current Alternating current Protective conductor terminal F...

Страница 68: ...visories Handling symbols These handling symbols and their associated text can appear on labels affixed to the outer packaging of Waters instrument and component shipments Keep upright Keep dry Fragil...

Страница 69: ...pillary column via a T piece connected to the heated transfer line An auxiliary EPC unit installed on the Agilent GC supplies and controls the make up gas To maintain constant make up gas flow as the...

Страница 70: ...moves any contaminated portion of the capillary column 3 Connect the capillary column to the inlet at either the front or back inlet port of the Agilent GC in accordance with the Agilent GC user docum...

Страница 71: ...apillary column so that no more than 1 mm of the column tip extends from the source end of the heated transfer line see page 1 8 8 At the oven end of the heated transfer line use the 4 mm wrench to gr...

Страница 72: ...B 4 Installing the GC Column...

Страница 73: ...C 1 C Preparing Sample Vials If you need to use reference or modifier samples you must prepare vials for use with the APGC Contents Topic Page Preparing vials C 2...

Страница 74: ...th Vial crimper Syringe To prepare closed vials 1 Place approximately 100 L of sample in a crimp top autosampler vial 2 Use the vial crimper to secure a septum cap on the vial 3 Use the ceramic wafer...

Страница 75: ...C 3 Preparing open vials Required materials Chemical resistant powder free gloves 1 5 mL crimp top autosampler vials To prepare open vials Place approximately 0 5 mL of modifier sample in a crimp top...

Страница 76: ...C 4 Preparing Sample Vials...

Страница 77: ...g A 5 cleaning corona pin 3 4 sample cone 3 4 corona pin adjusting 2 10 cleaning 3 4 replacing 3 4 E EC authorized representative viii electrical symbols A 11 equipment guidelines vi A 6 F flammable s...

Страница 78: ...ple cone cleaning 3 4 source enclosure APGC installing 2 12 LC installing 2 24 source ion block preparing for GC operation 2 5 preparing for LC operation 2 22 source working on 2 2 spare parts 3 2 sym...

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