Thermo Scientific Corona Veo, Руководство по эксплуатации

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6 • Operation
Charged Aerosol Detectors Corona Veo (RS) Operating Manual Page 161
To interrupt operation for a longer period, follow the instructions below.
1. Remove the column.
2. Flush the detector with an appropriate, pure solvent (minimum
LC/MS-grade) that does not contain any additives. Make sure that
residual sample components, impurities from the column, or buffers
are completely removed from the detector.
Observe the following:
♦ Detector remains in the laboratory after shutdown
♦
If no additive is used, flush the system, for example with
methanol. 100% acetonitrile should not be used.
♦
If an additive is used, flush the system with several volumes
(for example, 1.0 mL/min for 10 minutes with the standard
system) of methanol and water (50:50) to prevent salt
buildup in the fluidics. If the solvents in the detector are not
miscible with water, use an appropriate intermediate
solvent.
♦ Detector shall be transported or shipped after shutdown
♦
If no additive is used, flush the system with isopropanol.
♦
If an additive is used, flush the system first with several
volumes (for example, 1.0 mL/min for 10 minutes with the
standard system) of methanol and water (50:50) to prevent
salt buildup in the fluidics. If the solvents in the detector are
not miscible with water, use an appropriate intermediate
solvent. Afterward, flush the system with isopropanol.
TIP As an intermediate solvent, you can use 100% methanol to flush
the charged aerosol detector.
3. Turn off the pump flow and then the gas flow:
a) Turn off the pump flow to the detector. Wait at least 5 minutes.
During the waiting period, the detector drains any remaining
mobile phase to waste.
b) Turn off the gas flow on the detector.
c) Wait until the system pressure is down to zero before you
continue.
d) Turn off the gas supply to the detector.