IF.PUG.014 R4
TANGENX™ PRO CASSETTE INSTALLATION
1.
Lift the end plate off the manifold of the TangenX™ PRO cassette holder.
2.
Remove the protective blue sheet and rinse the Silicone gaskets with deionized
water or WFI. Place a rinsed gasket flat against the bottom manifold; ensure
that the holes in the gasket line up with the holes in the manifold.
3.
Using scissors carefully open the cassette bag to remove cassette.
WARNING: Each cassette is stored in an aqueous solution
containing 15-20% glycerin and 0.1% sodium azide, pH 7 - 10. Follow
standard safety procedures for handling aqueous glycerin/sodium
azide, including the use of gloves, safety goggles, and lab coat.
4.
Place the cassette into the holder flat against the gasket. Place another gasket
on top of the cassette. Ensure that the holes in the manifold, gaskets, and
cassette are completely aligned. If you are using multiple cassettes, continue
the same gasket/cassette/gasket pattern, ending with a gasket between the
last cassette and the end plate.
5.
Place the end plate on top of the last gasket of the cassette or cassette stack.
6.
Install the tie-rod spacers (if used) and washers on each bolt leaving a
minimum of 18 mm (0.75 inch) of thread exposed on the rod. By hand, screw
the nut on each bolt and hand tighten evenly by alternating from one nut to
the other. Bolts must be further tightened to within the recommended torque
values using a calibrated manual torque wrench.
7.
Proceed to step 8 for a four bolt hardware design or skip to step 9 for a two
bolt hardware design.
8.
Using the calibrated torque wrench with a deep style socket, tighten each hex
nut ¼ turn following the torque sequence illustrated in Figure 2 for a four bolt
horizontal hardware. In ¼ turn increments, tighten the first (H1), second (H2),
third (H3), and fourth (H4) nut alternating back and forth until the torque
wrench "clicks". Repeat this sequence until the wrench "clicks" without
turning the nut. The "click" of the torque wrench indicates that the nut has
reached the set point torque value.
9.
Using the calibrated torque wrench with a deep style socket, tighten each hex
nut ¼ turn following the torque sequence illustrated in Figure 3 for a two-bolt
vertical hardware. Tighten the first nut ¼ turn, and then tighten the second
nut ¼ turn alternating back and forth until the torque wrench "clicks". Repeat
this sequence until the wrench "clicks" without turning the nut. The "click" of
the torque wrench indicates that the nut has reached the set point torque
value.
CAUTION: Nuts must be
tightened uniformly to
avoid damaging the
cassette. Leakage may
result from non-parallel
plate alignment or over
compression of the
cassettes at one end.
10.
Wait 5-10 minutes and allow the gaskets to relax before re-torqueing. Check
each nut, per the Figure 2 or 3 sequences, using the torque wrench at its set
point torque value.
11.
Re-torque as needed, to create a liquid-tight seal.
NOTE: Torque may change during processing as the cassettes may
compress, or as the cassettes expand or contract with temperature
changes. Periodically check the torque of the bolts and adjust
torque as needed.
TangenX™ PRO
Cassette Holder
COMPATIBILITY GUIDE
REPLIGEN TANGENX™ STANDARD WARRANTY
Repligen Corporation
warrants its TangenX™ products will meet their
applicable published specifications when used in accordance with their
applicable instructions for a period of one year from shipment of the
products.
REPLIGEN MAKES NO OTHER WARRANTY, EXPRESSED OR
IMPLIED. THERE IS NO WARRANTY OF MERCHANTABILITY OR FITNESS FOR
A PARTICULAR PURPOSE.
The warranty provided herein and the data,
specifications and descriptions of Repligen TangenX™ products appearing in
published catalogues and product literature may not be altered except by
express written agreement signed by an officer of Repligen.
Representations, oral or written, which are inconsistent with this warranty or
such publications are not authorized and if given, should not be relied upon.
In the event of a breach of the foregoing warranty, Repligen’s sole obligation
shall be to repair or replace, at its option, the applicable product or part
thereof, provided the customer notifies Repligen promptly of any such
breach. If after exercising reasonable efforts, Repligen is unable to repair or
replace the product or part, then Repligen shall refund to the customer all
monies paid for such applicable product or part.
REPLIGEN SHALL NOT BE
LIABLE FOR CONSEQUENTIAL, INCIDENTAL, SPECIAL OR ANY OTHER
DAMAGES RESULTING FROM ECONOMIC LOSS OR PROPERTY DAMAGE
SUSTAINED.
FIGURE 3
TORQUE SEQUENCE FOR
TANGENX™ PRO CASSETTES
(2 Bolt Design)
Phone 508.845.6400 | Fax 508.845.3030
FIGURE 2
TORQUE SEQUENCE FOR TANGENX™ PRO CASSETTES
(4 Bolt Design)
