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FineLINE 35 oligo column

Operating Instructions

Original instructions

Содержание FineLINE 35

Страница 1: ...FineLINE 35 oligo column Operating Instructions Original instructions cytiva com...

Страница 2: ...6 5 6 Scalingup 27 6 Maintenance 28 6 1 SafetyPrecautions 29 6 2 Usermaintenanceschedule 30 6 3 Cleaning 31 6 4 Storage 32 6 5 Disassemblyandassembly 33 6 6 Componentmaintenance 36 7 Troubleshooting 3...

Страница 3: ...boutthismanualandassociateduserdocumenta tion importantuserinformationandintendeduseoftheproduct Inthischapter Section Seepage 1 1 Importantuserinformation 4 1 2 Aboutthismanual 6 1 3 Abbreviations 7...

Страница 4: ...agnostic purposes Prerequisites InordertooperateFineLINE35oligocolumnsafelyandaccordingtotheintended purposethefollowingprerequisitesmustbemet Youshouldbeacquaintedwiththeuseofgenerallaboratoryequipme...

Страница 5: ...Hardwareitemsareidentifiedinthetextbyboldtext Inelectronicformat referencesinitalicsareclickablehyperlinks 1 Introduction 1 1 Importantuserinformation FineLINE35oligoOperatingInstructions28964957AB 5...

Страница 6: ...ntions Softwareitemsareidentifiedinthetextbybolditalictext Hardwareitemsareidentifiedinthetextbyboldtext Inelectronicformat referencesinitalicsareclickablehyperlinks Notesandtips Note A note is used t...

Страница 7: ...ETP heightequivalenttoatheoretical plate heightequivalenttoatheoretical plate HIC hydrophobicinteractionchromatog raphy hydrophobicinteractionchromatog raphy PEEK Polyetheretherketone Polyetheretherke...

Страница 8: ...cribesemergencyandrecoveryprocedures Inthischapter Section Seepage 2 1 Safetyprecautions 9 2 2 Labelsandsymbols 14 Important WARNING Beforeinstalling operatingormaintainingtheproduct all usersmustread...

Страница 9: ...horseriousinjury Itisimportantnottoproceed untilallstatedconditionsaremetandclearlyunderstood CAUTION CAUTIONindicatesahazardoussituationwhich ifnotavoided couldresultinminorormoderateinjury Itisimpor...

Страница 10: ...requirements e g tubingwithstandsoperatingpressureandhas adequatechemicalresistance WARNING ThereshouldNEVERbeairorgasunderpressureinthecolumn Flammableliquidsandexplosive environment WARNING Riskasse...

Страница 11: ...lasses andotherpersonalprotectiveequipmentappropriateforthe currentapplicationatalltimes Thefollowingpersonalprotective equipmentshouldalwaysbeavailable Protectiveglasses Workingglovestoprotectagainst...

Страница 12: ...column espe ciallyifhydraulicsareconnectedtothecolumn Theforcegener atedbythemovementofthecolumncouldcrushhandsandlimbs CAUTION Makesurethatanyaccessoriesusedfulfillthespecification requirements e g t...

Страница 13: ...sories Useonlyaccessoriessuppliedorrecommendedby Cytiva WARNING Decontaminatebeforemaintenance Toavoidpersonnelbeing exposedtopotentiallyhazardoussubstances makesurethatthe columnisproperlydecontamina...

Страница 14: ...lowingtable Symbol text Description Codeno OrderingnumberforFineLINE35oligocolumn Designpressure Thedesignpressure whichmustneverbeexceeded Warning Readtheuserdocumentationbeforeusingthe system Donoto...

Страница 15: ...mn 1 2 3 4 5 6 7 8 9 10 11 Part Description 1 Columntopconnection 2 Adaptershaft 3 Mechanicallockingunit 4 Bayonetadapterlidlock 5 Columntoplid 6 Connectingrod 7 Columntube 8 Adapterfilterunit 9 Botto...

Страница 16: ...tainsthebottomfilterunitandstainlesssteel 316L filter andanO ringsealstheunitagainstthecolumntube Materials Allcolumnpartsaremanufacturedfromhighqualitymaterialsandmeettherequire mentsofindustrialenvi...

Страница 17: ...ofthecolumnarelocatedatthebottomofthecolumn inthe bottomlid andinthecolumntop Theinletandoutletshave5 16 fittingandthehydraulicchamberhasM6fitting 3 Systemdescription FineLINE35oligoOperatingInstructi...

Страница 18: ...ocolumnisdeliveredassembled withtheadapterfittedinthe column Packinglist Item Articleno Qty FineLINE35oligocolumn 28946841 1 Usermanual 28964957 1 Hexkey4mm 59037900 1 Hexkey2 5mm 59444200 1 Union5 16...

Страница 19: ...FineLINE35oligocolumninsafe way Inthischapter Section Seepage 5 1 Safetyprecautions 20 5 2 Packingthecolumn 22 5 3 Lekagetest 24 5 4 Recommendedoperatingconditions 25 5 5 Unpackingthecolumn 26 5 6 Sca...

Страница 20: ...tsofthecolumntube Thepressurespecificationsareonly validiftheglasstubeisundamaged WARNING Max columnpressure Theworkingpressureofthecolumn shouldneverexceed20bar otherwisethereisariskofpersonal injury...

Страница 21: ...akesurethatthepressurereliefvalveiscorrectlyadjustedand thatconnectingtubinghasanunrestrictedflowpath NOTICE Toavoidprecipitationkeepallreagentsatorabove18 C NOTICE Noothersolventsthanthosespecifiedin...

Страница 22: ...peratingInstructions 1 Hexkey4mm 1 Union5 16 female M6male 2 TubingConnectorsOD1 8 tubing 12 FerrulesforOD1 8 tubing 12 Stopplug5 16 1 TubingID1 6mmOD1 8 30cm 2 TubingID1 6mmOD1 8 40cm 3 100or250mLbot...

Страница 23: ...eredlinesonthe column 6 Wettheadapterwith50 to95 ethanol 7 Connectstopplugtothebottomofthecolumn 8 Connectatubetotheadapterandinserttheotherendsecurelyintoawaste vessel 9 Inserttheadapter Adjustthecol...

Страница 24: ...min 2 Doacheckifliquidcomesoutfromthecolumnoroutfromconnection points 3 Ifnoleakageisdetected proceedtostartarun 4 Ifaleakageisdetected a Localizetheleakage b Determinethecauseoftheleakage SeeGeneral...

Страница 25: ...ecolumn throughthebottomfilterandexitthroughthetopadapterfilter Simplifyingfilterchanging Usingflowdirectionfrombottomtotopalsosimplifieschangingadirtyadapter filter sincetheinletfiltermostlikelyisdir...

Страница 26: ...NG ThereshouldNEVERbeairorgasunderpressureinthe column 4 Continuetheairflowuntilthesupporthasreducedinvolumeandisfree fromthecolumnwall Thiswilltakeapproximately30minutesdependingon theamountofsupport...

Страница 27: ...tedlargescaleequipmentandthespecialaspects ofliquidhandlingandprocesscontrolathighvolumetricflowrates Linearflowratesandthenumberofcolumnvolumesusedduringmethoddevelop mentshouldgenerallybethesameasth...

Страница 28: ...ntenance shouldbeperformedannuallybyaCytivaserviceengineer orservicepersonnel authorizedbyCytiva Alistofplannedmaintenanceactionsispresentedinthis chapter Inthischapter Section Seepage 6 1 SafetyPreca...

Страница 29: ...remaintenance Toavoidpersonnelbeing exposedtopotentiallyhazardoussubstances makesurethatthe columnisproperlydecontaminatedandsanitizedbeforemainte nanceorservice CAUTION Makesurethatanyaccessoriesused...

Страница 30: ...aning on page 31 Filtercare RefertoSection 6 2 User maintenance schedule on page 30 Afterevery10 thsynthesis runoronceperyear which evercomesfirst O ringcheck RefertoO ring check and replacement on pa...

Страница 31: ...enance schedule on page 30 Allcolumnpartscanbecleanedwiththemostcommonlyusedagents suchasdeter gents ethanol methanolandweakacids Forchemicalresistancetospecialcleaning agents seeSection 8 2 Chemical...

Страница 32: ...ordingto Section 6 3 Cleaning on page 31 Letthepartsdrythoroughlyaftercleaning Thecolumnshouldthenbestoreddismantledinadryanddustfreelocation Whentakenintoserviceafterstorage makesurethattheO ringsare...

Страница 33: ...andglovesresistanttothesubstancesused Followlocal and ornationalregulationsforsafeoperationandmaintenanceof theproduct CAUTION Afterassembly makesurethatthecolumnistightandnotleaking NOTICE Whenworkin...

Страница 34: ...dcounter clockwisefromthelockedpositionlabelled 2 onthetopend piecetoposition 1 asshownintheillustration a Ifneces sary usethesuppliedwrench b 2 Wettheadapterrodwithethanolandpulltheadapterlidtoitsupp...

Страница 35: ...he suppliedwrench a 3 Wettheadapterfilterunitandtheadapterrodwithethanol 4 Movetheadapterlid b toitslowerstopposition 5 Inserttheadapterintothecolumntubesothattheslotintheadapterlidis positioneddirect...

Страница 36: ...eSection 6 2 User maintenance schedule on page 30 TheFineLINE35oligocolumnisdesignedwithaminimumofcomponents whichfacili tatescleaningandreliableoperation Innormalroutineoperation thecolumnrequires on...

Страница 37: ...ntube 3 Tightenthebottomfilter Adapterfilterunitreplacement Step Action 1 Unscrewthetwoscrewsthatholdtheadapterfilterunitandremoveitfrom theadapterrod 2 Gentlypulloutthefilterunit 3 Unscrewtheadaptert...

Страница 38: ...above Unscrewthetwoscrews thatsecuretheadapterknobandthecolumninlet 2 Pulloutthetubingfromtheadapterrod Unscrewtheadapterknobfrom thetubingusingtheplasticwrenchsupplied 3 Insertanewtubing OD1 8 235mm...

Страница 39: ...flow Iftheback pres sureincreaseisduetoablockageinthecolumn thefollowingproceduresshouldbe employed Problem Check possiblecauses Highbackpressure Columnfiltersblocked ifso cleanorreplace RefertoSectio...

Страница 40: ...toryinforma tionandorderinginformation andHealthandSafetyDeclarationformforservice Inthischapter Section Seepage 8 1 Specifications 41 8 2 Chemicalresistance 42 8 3 Serviceandtraining 43 8 4 Recycling...

Страница 41: ...r 1 2mm Footprint 250x250mm Netmeshsize 15 m absolute20 m Recommendedbedheight 1to10cm Designpressure 20bar Flowvelocityrange 0to200mL min Note Using Primer Support according to recommended packing pr...

Страница 42: ...attheeffectsofachemicalwillbemoresevereathighertempera turesandpressures andthatcombinedeffectshavenotbeentakenintoconsidera tion Concentrationsareexpressedas volumeofsaturatedsolutionunlessotherwise...

Страница 43: ...3 Service and training ContactyourCytivarepresentativeregardingserviceandtrainingforFineLINE35oligo column 8 Referenceinformation 8 3 Serviceandtraining FineLINE35oligoOperatingInstructions28964957AB...

Страница 44: ...Theproductmustbedecontaminatedbeforedecommissioning Alllocalregulations mustbefollowedwithregardtoscrappingoftheequipment Disposal Whentakingtheproductoutofservice thecolumnshouldbeemptied cleanedand...

Страница 45: ...ststheregulationsandstandardsthatapplytotheproduct Inthissection Section Seepage 8 5 1 Contactinformation 46 8 5 2 EuropeanUnionandEuropeanEconomicArea 47 8 Referenceinformation 8 5 Regulatoryinformat...

Страница 46: ...Manufacturinginformation Thetablebelowsummarizestherequiredmanufacturinginformation Requirement Information Nameandaddressofmanufacturer CytivaSwedenAB Bj rkgatan30 SE75184Uppsala Sweden Telephonenumb...

Страница 47: ...notincludedwiththeproduct acopyoftheEUDeclarationofConformityisavailable onrequest CEmarking TheCEmarkingandthecorrespondingEUDeclarationofConformityisvalidforthe instrumentwhenitis usedaccordingtothe...

Страница 48: ...umnsystem Precautions WARNING Accessories Useonlyaccessoriessuppliedorrecommendedby Cytiva CAUTION Makesurethatanyaccessoriesusedfulfillthespecification requirements e g tubingwithstandsoperatingpress...

Страница 49: ...ustration It fits between the Adapter Lid 3 and the Adapter tube 6 Thetablebelowdescribescomponentpartsandaccessories Theitemnumbersrefer totheillustrationabove Itemswithoutarticlenumbercannotbeordere...

Страница 50: ...lterunit35 PEEK 316L 1 18113716 Yes Yes 17 Bottomendpiece POM 1 No No 18 Adhesivefootpads 4 No No 19 Bottomfilterunit35 PEEK 316L 1 18113717 Yes Yes 20 NutM6 316 3 No No 21 O ring3 6x1 6 EPDM 2 181142...

Страница 51: ...Qty Articleno Wetted process Wetted hydraul WrenchFineLine351 1 18111088 WrenchM6 1 19748101 OperatingInstructions 1 28964957 8 Referenceinformation 8 6 Orderinginformation FineLINE35oligoOperatingIns...

Страница 52: ...some cases this may require customer to move equipment from normal operating location prior to Cytiva arrival Consumables such as columns or gels have been removed or isolated from the instrument and...

Страница 53: ...must be decontaminatedprior to service return Provide a telephone number where Cytiva can contact you for additional information concerning the system equipment Telephone No Liquid and or gas in equip...

Страница 54: ...veowners 2020 2021Cytiva UNICORN 2021Cytiva AnyuseofUNICORNissubjecttoCytivaStandardSoftwareEnd UserLicenseAgreementforLifeSciencesSoftwareProducts Acopy ofthisStandardSoftwareEnd UserLicenseAgreement...

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