Freeze-dryer Epsilon 2-6D LSCplus
6 Operation
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Version 07/2022, Rev. 3.0 of 20/07/2022
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Translation of the original operating manual
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6.7
Optional extensions and special equipment
The freeze-dryer can be equipped with the following optional equipment.
Special equipment cannot be retrofitted.
Option: Controlled Nucleation LyoCoN
The LyoCoN process enables the simultaneous freezing of all vials inside
the drying chamber. To this end, ice crystals are accumulated on the cold
ice condenser. At the same time, the liquid product is cooled to a
temperature close to the freezing point. Then, a slight vacuum is generated
inside the freeze-dryer. A reservoir, which has been installed externally,
remains at atmospheric pressure. When the valve between the external
reservoir and the ice condenser chamber is opened, the pressure will be
equalised. The gas that passes by the ice condenser produces an
extremely fine ice mist inside the drying chamber. This ice mist enters into
all of the vials, thereby causing immediate and homogeneous freezing.
Option: Wireless product temperature measurement system WTMplus
The wireless product temperature measurement system WTMplus has
been developed mainly for freeze-dryers in the production area. The
sensors are positioned directly in the product. They transfer their
measurement values to an antenna that is integrated in the drying
chamber. This enables the continuous monitoring of all of the phases of the
freeze-drying process.
Option: Pressure increase test
see also chapter 6.6.3.1 - "Creating a program", button ">>more"
The pressure increase test can only be performed with the
→
double-
chamber method
. During the pressure increase test, the intermediate valve
prevents the flow of steam from the drying chamber to the ice condenser so
that the water vapour of the
→
sublimation
cannot flow off. The result is a
more or less distinct pressure increase that is measured in the product
chamber. The pressure increase test is used as a criterion for the automatic
switching from the main drying phase to the final drying phase as well as
for identifying the end of the process.
Option: Improved cooling rate (fast freezing)
Refrigeration unit 1 is used for cooling the ice condenser. Refrigeration
unit 2 cools the heat transfer fluid that is used for controlling the
temperature of the shelves. If the device option "Improved cooling rate" is
activated (see chapter 6.6.1.3 - "Main window
"Options""/Administration/Device options), the ice condenser refrigeration
unit will be used during the "Freezing" phase to support the cooling of the
heat transfer fluid. This enables higher freezing rates
This option is only available for freeze-dryers of the Epsilon 2-6D LSCplus
and Epsilon 2-10D LSCplus type.
