Freeze-dryer Epsilon 1-4 LSCplus
Freeze-dryer Epsilon 2-4 LSCplus
1 General information
Version 07/2022, Rev. 3.0 of 20/07/2022
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Translation of the original operating manual
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1.3.1
Freeze-drying of solvent-containing products (non-aqueous media)
With regards of corrosion resistance, the use of some organic solvents in
aqueous solutions with low concentrations is acceptable.
A freeze-dryer is designed to be chemically resistant to most compounds
that are commonly used in freeze-drying processes. However, by
necessity, the freeze-dryer is comprised of several different materials,
some of which may be attacked and degraded by certain chemicals.
The methods of fabrication and/or conditions of exposure of an acrylic door,
as well as the way the chemicals are applied, can influence the results.
Some of these factors are listed below:
• Fabrication: Stress generated while sawing, sanding, machining,
drilling, polishing, and/or forming.
• Exposure: Length of exposure, stresses induced during the life of the
product due to various loads, changes in temperature etc.
• Application of chemicals: by contact, rubbing, wiping, spraying etc.
The following table can be used as a general guide for the expected
degradation during normal freeze-drying processes of organic solvents with
a total max. concentration of 10 vol-% in aqueous solutions.
Solvent
Acrylic
glass
Stainless
steel
Silicon
rubber
EPDM
Acetic acid 20%
+
+
+
o
Formic acid up to 10%
+
o
o
-
Trifluoracetic acid (TFA)
-
+
o
+
Calcium chloride
+
+
+
+
Sodium phosphate
+
+
-
+
Acetone
-
+
+
+
Acetonitrile
-
+
-
o
Carbon tetrachloride
-
+
-
-
Cyclohexane
+
+
-
-
Dioxane
-
+
-
o
Methyl-t-butyl ether
+
+
o
-
Pyridine
-
+
-
o
Methanol
-
+
+
+
Ethanol
o
+
o
+
tert-Butanol
-
+
-
o
DMSO
-
+
-
+
Legend:
+ No degradation to be expected
o Moderate degradation; limited use
- Severe degradation; infrequent use recommended;
immediate thorough cleaning required
