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9. HEMATOLOGY

In the Hematology Mode there are a number of different programs that can be used. All are based on

commercially available kits. The programs include IHSA I-125, Cr-51 Blood Volume, Cr-51 Red Cell

Survival, Glomerular Filtration Rate (GFR) and Effective Renal Plasma Flow (ERPF).

The Hematology Patient Page

(See Figure 8-1.)

Setting Up For Hematology

To set up for any of the hematology procedures, click on the <Procedure Definition> icon in the

primary tool bar to select the Procedure Definition window.

Open the procedure list and correct or change any parameters for any procedure or create a new

procedure with the requirements for your studies.

NOTE: Once you have created the standard procedure for this study, you do not have to go back to this

window and modify it. It will be stored and usable for any future patient studies of this type.

Click on the <Patient Definition> icon in the primary tool bar. The Patient Definition window should

now be displayed. For an existing patient, simply add the new procedure. For a new patient, add the

patient and the procedure.

NOTE: We recommended creation of a new procedure rather than modification of an existing procedure.

Once a patient is in the system and the appropriate hematology method is listed for that patient,

select that patient and proceed to the Hematology Counting page. You can now proceed to the

appropriate test as described below.

IHSA I-125

(See Figure 9-1 and 9-2.)

To perform an IHSA I-125 study, follow the kit instructions for preparing and administering the dose.

When preparing to count the different parts of the study, be sure to have all the vials set up so they can be

counted one after the other to negate any decay factors.

To start the study, verify that the correct patient and patient ID# is listed at the top of the

Hematology Counting page.

Click on <Preferences> at the right side of the screen and verify the volumes and dosage used.

Correct the count time if desired. After reviewing the window and parameters, click <OK>.

Click on <Background> to perform a background count for the I-125 window. When done counting, the

system will display the counts and CPM. The <Iodine Standard> button should now be highlighted.

Remove the vial that was used for counting background and place the vial with the iodine standard

into the well counter. Click on <Iodine Standard> to count the standard. When done counting the

system will display the counts and the counts per minute.

Remove the vial with the iodine standard and place the blood sample vial into the well counter.

Click on <Blood Sample> to begin counting the blood sample. When done counting, the system

displays the counts and CPM for the blood sample.

Remove the blood sample vial from the well counter and put the plasma sample vial into the

well counter.

9-1

HEMATOLOGY

Содержание 187-130

Страница 1: ...OPERATION MANUAL 187 130 187 135 187 140 187 145 BIODEX Biodex Medical Systems Inc 20 Ramsay Road Shirley New York 11967 4704 Tel 800 224 6339 In NY and Int l call 631 924 9000 Fax 631 924 9241 Email sales biodex com www biodex com FN 05 211 6 05 ...

Страница 2: ...ke System Atomlab 950 ATOMLAB 950 PC 0413 NOTE All or some of the following symbols cautions warnings and notes may apply to your Atomlab 950 and correspond to this operation manual Symbol Meaning Attention consult accompanying documents Symbol signification Attention se référer à la notice Warning Injuries to health may result from incorrect or excessive training Attention incorrect ou extrême en...

Страница 3: ... Paris France WARRANTY ATOMLAB Thyroid Uptake Systems carry the industry s best warranty Biodex Medical Systems backs Atomlab Thyroid Uptake Systems with a truly comprehensive full two year warranty It covers both parts and labor and includes all unit elements Biodex s two year warranty is a sure sign of product quality and dependability With this two year warranty quality assurance guaranteed del...

Страница 4: ...ermined 3 24 4 Thyroid Uptake 4 1 Defining a Facility Standard Uptake Procedure 4 1 Patient Definition Screen 4 4 Determining Automatic Count Time 4 5 Performing a Thyroid Uptake 4 7 Printing a Thyroid Uptake Report 4 12 Printing a Time Activity Uptake Report 4 12 5 Manual Mode 5 1 To Count in Manual Mode 5 1 To Print in Manual Mode 5 1 Spectrum Analysis 5 1 6 Wipe Test 6 1 Define Wipe Areas 6 1 S...

Страница 5: ...ogy Patient Page 9 1 IHSA I 125 9 1 Cr 51 Blood Volume 9 3 Cr 51 Red Cell Survival 9 9 GFR 9 11 Effective Renal Plasma Flow 9 17 Appendix A Isotope Efficiency Calculation A 1 Appendix B Specifications B 1 Appendix C Electromagnetic Compatibility C 1 Schematics S 1 ...

Страница 6: ...tion using 23 pre programmed isotopes 50 user defined radionuclides and menu driven prompts to guide the user step by step through each procedure The pre programmed radionuclides include I 123 I 125 I 131 Co 57 Cr 51 Tc 99m and Cs 137 The user defined radionuclides also allow for isotope identification while the printer provides hard copy printouts for patient and department record keeping The Ato...

Страница 7: ... side use a medium slotted screwdriver to remove the four screws that hold the well support shelf in place remove the shelf and replace the screws Now remove the four screws on the other side of the vertical column and use these to secure the well 7 The large shelf side cable hole cover should be positioned on the same side as the keyboard If it is not use a Phillips screwdriver to remove the scre...

Страница 8: ...1 INTRODUCTION SETUP INSTRUCTIONS 2 2 Figure 2 1 The MCA Uptake Stand ...

Страница 9: ...ough the large shelf side cable hole down through the large shelf vertical cover cable hole down through the printer shelf vertical cover cable hole and finally back up through the printer shelf cable hole Allow eight to ten inches of the cable to protrude through the printer shelf cable hole 17 Reinstall the vertical cable cover using a Phillips screwdriver and the three screws removed in step 5 ...

Страница 10: ...1 INTRODUCTION SETUP INSTRUCTIONS 2 4 Figure 2 2 The MCA Uptake Stand side view ...

Страница 11: ... shelf Make sure it faces the front of the stand where the operator will be working 29 Slide the CPU toward the back of the large shelf Place the keyboard and trackball mouse on the shelf in front of the CPU The keyboard should be to the left of the trackball 30 Run the free end of the keyboard cable along the side of the CPU and plug it into the keyboard port at the back of the CPU 31 To install ...

Страница 12: ... probe cables which now extrude from the front of the MCA shelf to the appropriate fittings on the back of the MCA The larger connector MHV is for high voltage the smaller BNC connector is for signal 47 If you have a well counter connect the larger MHV well cable connector to the well high voltage fitting and the smaller BNC connector to the well signal port on the back of the MCA 48 Plug the fema...

Страница 13: ...isplayed 5 Select Start Now click on Shut Down and then OK The system will now take several seconds to shut down the computer When finished a message will appear on the screen noting that it is safe to turn the system OFF Turn the power strip off at this time You can now unplug the system and move it to the location where it will be used NOTE The push handle can be used as a wire wrap to hold the ...

Страница 14: ...e screen pointer appropriately To select any option on the screen simply use the trackball to locate the cursor over the desired icon and click the left trackball button An hour glass icon appears over the selected option icon indicating that the system is advancing to the selected option After a second or two the new menu screen or page appears To see how the mouse works select the Calibration Ta...

Страница 15: ...1 INTRODUCTION 2 9 SETUP INSTRUCTIONS Figure 2 3 Click OK on the About Atomlab 950 Screen to Begin the Self Test ...

Страница 16: ...1 INTRODUCTION SETUP INSTRUCTIONS 2 10 Figure 2 4 The Atomlab 950 PC Operation Screen is displayed at completion of the self test The system is now ready for use ...

Страница 17: ...an item to the current operation For example on the isotope page you can add an isotope On the patient page you can add patients Edit This button allows you to go in and edit the item that you are displaying Save Use this option to save any changes or new information that you have entered on the current page Stop Cancel button will cancel whatever work you were just doing without saving any change...

Страница 18: ...1 INTRODUCTION Figure 2 5 The Isotope Editing Screen SETUP INSTRUCTIONS 2 12 Primary Tool Bar Menu Bar Screen Tool Bar ...

Страница 19: ...ation mode if desired If you select Simulation mode the system returns to the desktop You can then click on Start followed by Programs Biodex Medical Systems and Atomlab 950 Simulation to enter Simulation mode To exit Simulation mode click on the X in the upper right corner of the screen to return to the desktop You can then turn the MCA box ON and double click on the Atomlab 950 desktop icon to a...

Страница 20: ...1 INTRODUCTION SETUP INSTRUCTIONS 2 14 Figure 2 6 The System Setup Screen ...

Страница 21: ...eys to move from field to field 4 Click Save to save the new entry to the database 5 Click Return to System Setup to return to the System Setup screen To edit a physician or technologist 1 Click Edit Physician and Technologist to access the Edit Physician and Technologist screen 2 Click Physician or Technologist to highlight the desired database The physician or technologist list will be displayed...

Страница 22: ...1 INTRODUCTION SETUP INSTRUCTIONS 2 16 Figure 2 7 The Edit Physicians and Technologists Information Screen ...

Страница 23: ...ht of the screen Choose 3 1 2 Floppy A from the drop down menu to select drive A then click on Open The system should return to the Back up screen with drive A now selected 6 Click on the Copy button in the bottom center of the screen to duplicate the source file onto the floppy NOTE To copy all of the patients in the database you can highlight all the patients by clicking on the first one and the...

Страница 24: ...Yes and the system will proceed to remove the information When you are done click on the Exit button in the center and this will take you back to the regular Atomlab program NOTE If there is already data in a patient file you must delete that patient in the backup before you can transfer from the original data NOTE To back up procedures you must save the Isotope information to the backup before tr...

Страница 25: ...1 INTRODUCTION 2 19 SETUP INSTRUCTIONS Figure 2 8 The Database Manager Screen ...

Страница 26: ...cally from the MCA Calibration screen This screen advises when the last high voltage and calibration were performed for your detectors It also checks to ensure that the MCA box and CPU are connected and communicating with each other Additionally the calibration calculates full width half max FWHM FWHM is determined by interpolating between two immediate points above and below the 50 value of the s...

Страница 27: ...ights which has zero offset A spectrum results when a histogram of these pulse heights channels is plotted Calibration of the spectrometer is defined as knowing the energy equivalence of each channel This is accomplished by determining the Cs 137 spectrum and then calculating the ratio of the 662 keV peak channel After calibration the report should always print a peak value very close to 662 keV s...

Страница 28: ...CONTENTS 3 3 ADMINISTRATION Figure 3 1 The Calibration Screen ...

Страница 29: ...1 INTRODUCTION Figure 3 2 A Calibration Report ADMINISTRATION 3 4 ...

Страница 30: ...r function specific counting information Each mode has a Start button Clicking on Start immediately begins the counting The Abort button is used to stop counting without storing the data The Stop button stops the MCA from counting but continues to use the information gathered in the program in which you are working High Voltage Adjustment should be performed the very first time the system is used ...

Страница 31: ...1 INTRODUCTION Figure 3 3 The High Voltage Adjustment Screen ADMINISTRATION 3 6 ...

Страница 32: ...1 INTRODUCTION Figure 3 4 The High Voltage Report 3 7 ADMINISTRATION ...

Страница 33: ...ays pass or always fail Chi Square without raising concerns that there may be a systematic problem in the detector or counter NOTE The system stores the information for the latest Chi Square test performed on a detector Chi Square can be performed as frequently as desired but is generally performed quarterly To Perform Chi Square 1 Click on the Chi Square tab in the center of the Calibration scree...

Страница 34: ...1 INTRODUCTION Figure 3 5 The Chi Square Screen 3 9 ADMINISTRATION ...

Страница 35: ...1 INTRODUCTION Figure 3 6 The Chi Square Report ADMINISTRATION 3 10 ...

Страница 36: ... Square results Isotope Editing See Figures 3 8 3 9 This option allows the user to select and view a preset isotope add a new isotope to the isotope list edit an existing user entered isotope and activate an isotope so that it can be used for Bioassay or Wipe functions The Atomlab 950 isotope list comes with 23 preset isotopes For these factory isotopes Lower Level Discriminator LLD Upper Level Di...

Страница 37: ...1 INTRODUCTION Figure 3 7 An Administration Report ADMINISTRATION 3 12 ...

Страница 38: ...d in the Isotope Name box All information on the Isotope Editing screen now reflects the new isotope 4 Click on Add 5 Enter a custom name for the new isotope and modify the specifications as required 6 Once all modifications are complete click Save at the top of the isotope menu If you do not wish to save what you have entered or want to get out of this screen click Cancel to exit without saving T...

Страница 39: ...ADMINISTRATION 3 14 1 INTRODUCTION Figure 3 8 The Isotope Editing Screen ...

Страница 40: ...1 INTRODUCTION 3 15 ADMINISTRATION Figure 3 9 The Select Isotope Window ...

Страница 41: ...he isotope in relation to the detector 1 From any screen click on the Isotope icon in the primary tool bar The Isotope Editing screen should now be displayed 2 Click on Efficiency in the screen tool bar The Detector Efficiency screen should now be displayed 3 Click on Set in the Geometric Efficiency box and then select either well or probe You can now enter information concerning the selected dete...

Страница 42: ...1 INTRODUCTION 3 17 ADMINISTRATION Figure 3 10 The Detector Efficiency Screen ...

Страница 43: ...or Efficiency screen will be displayed 3 Highlight the appropriate detector and the appropriate isotope 4 Click on Factory Default This will place the analytically determined factory default value into the appropriate detector window 5 Click on Close to return to the Isotope Editing screen To Calculate a Detector Efficiency for a Specific Isotope 1 From any screen click on the Isotope icon in the ...

Страница 44: ...1 INTRODUCTION Figure 3 11 The Geometric Efficiency Window 3 19 ADMINISTRATION ...

Страница 45: ...ee Figures 3 12 and 3 13 Spectrum Analysis is available in any operational mode throughout the program This option allows the user to change the ROI on the display add additional ROI s or print the spectrum with counting information To Access The Spectrum Analysis 1 Click on Spectrum in the primary tool bar The Spectrum Analysis screen should now be displayed The spectrum from the immediately prec...

Страница 46: ...ure to go to a lower gain isotope the system may display a message that the lower limit of deection of Co 58 is above the window limit of the selected gain This message will be displayed for each isotope until you select one that has an acceptable gain Click on OK to remove the message window and select another isotope 4 To set multiple regions of interest on the screen click on Show Hide Cursors ...

Страница 47: ...re displayed on the Isotope Editing page When either the probe or well is selected the ROI channels are calculated based upon the Cs 137 calibration results for that particular detector If the calculation of the probe results in a 3775 keV channel on gain 8 the TC 99m default gain the channel ROI will be 119 keV 3775 keV channel channel 315 and 162 3775 channel 429 For the well detector we might h...

Страница 48: ...1 INTRODUCTION 3 23 ADMINISTRATION Figure 3 13 A Spectrum Analysis Report ...

Страница 49: ...ach of the data sets that are counted are displayed in the status window on the Thyroid Uptake screen NOTE If you have not yet calibrated your Atomlab 950 on this day the system will prompt you to calibrate before proceeding with the Thyroid Uptake or any other mode selected High Voltage must also be set before using the system for the first time Once the calibration and High Voltage have been per...

Страница 50: ...1 INTRODUCTION Figure 4 1 The Procedure Definition Screen THYROID UPTAKE 4 2 ...

Страница 51: ...1 INTRODUCTION 4 3 THYROID UPTAKE Figure 4 2 The Patient Definition Screen ...

Страница 52: ...imary tool bar The Patient Definition screen should now be displayed 2 Click on Edit in the screen tool bar The Patient List should now be displayed 3 Double Click on the desired patient to select that patient The Patient Definition screen should now be displayed with the patient to edit selected 4 Make the necessary edits by highlighting each parameter to edit then keying in the new information 5...

Страница 53: ...tween the four count times in a rational way which minimizes the count times for all four counts and thereby minimizes the amount of time the patient must remain immobile Because the count rate is high the Standard count time is usually short 6 seconds Time for the Lab Background is determined from the first few seconds of Lab Background counting If the count rate is very low the count time will b...

Страница 54: ...mum set count time of 60 sec The patient was required to remain in a counting position for only 29 seconds for the thyroid and 12 seconds for the background count This is very beneficial for hyperthyroid and elderly patients Plus the auto count time mode takes less time to set up The Uptake of 25 5 has a 2 uncertainty meaning it could be 25 1 to 26 1 NOTE In this example and the following two the ...

Страница 55: ...ted in the analysis The lab is subtracted from the standard Any error in the lab is carried forward into the overall error but the impact depends upon the relative counting rates If the standard is 10 000 times higher than the lab then a 50 uncertainty in the lab will only contribute a very small error to the difference As the lab rate increases with respect to the standard its error contribution ...

Страница 56: ...THYROID UPTAKE 4 8 1 INTRODUCTION Figure 4 3 The Thyroid Uptake Screen ...

Страница 57: ...he primary tool bar 6 Remove the capsule from the neck phantom and position the probe to measure lab background Click on the Lab Background icon fourth from left above ROI counts to begin the lab background count In auto count time the system will calculate the count rate and adjust the counting time automatically For manual counting the system counts for the time selected 7 When the lab backgroun...

Страница 58: ...THYROID UPTAKE 4 10 1 INTRODUCTION Figure 4 4 A Thyroid Uptake Report ...

Страница 59: ...1 INTRODUCTION Figure 4 5 A Time Activity Report 4 11 THYROID UPTAKE ...

Страница 60: ...e current lab background count 21 The system now displays a prompt to save results Click Yes to save the results with the number Click No to redo any count 22 When satisfied save the results After saving the thyroid uptake results the system returns to the MCA Operation screen You can now use the system for other operations if desired If you come back to this patient at a later time follow steps 1...

Страница 61: ...ame dose activity and any comments to be printed on the report 3 Click on Preview if you want to preview how the report will look when it is printed 4 Click on Print to print the report 5 Click on Close to return to the Thyroid Uptake screen NOTE Results can be listed in rads or in grey units of measure See Section 2 System Set Up 6 Click on Print to print the report 7 Click on Close to return to ...

Страница 62: ...anytime to stop counting and use the counts up to that point for results Click on Abort to cancel the current counting operation without using the current count The system will return to the Manual Mode screen 5 Once the count is completed the message Test Completed is displayed The results now appear in the Test Results window You may now count again in manual mode to build a report with multiple...

Страница 63: ...MANUAL MODE 5 2 1 INTRODUCTION Figure 5 1 The Manual Mode Screen ...

Страница 64: ...1 INTRODUCTION 5 3 MANUAL MODE Figure 5 2 A Manual Mode Report ...

Страница 65: ...ck on Wipe The Wipe Counting screen should now be displayed 2 Click on the Define Wipe Area icon at the bottom of the screen The Wipe Area Setup screen should now be displayed 3 If the currently selected wipe area is the one you want to edit proceed to step 5 To select another wipe area to edit click on Open in the screen tool bar The Wipe Area Selection List should now be displayed 4 Double Click...

Страница 66: ...1 INTRODUCTION WIPE TEST 6 2 Figure 6 1 The Wipe Counting Screen ...

Страница 67: ...6 3 WIPE TEST CONTENTS Figure 6 2 The Wipe Area Setup Screen ...

Страница 68: ...CONTENTS WIPE TEST 6 4 Figure 6 3 The Wipe Preferences Window ...

Страница 69: ...ng Wipe Area at the Operation screen click on Wipe The Wipe Counting screen should now be displayed 2 Click on the Define Wipe Area icon at the bottom of the screen The Wipe Area Setup screen should now be displayed 3 If the currently selected wipe area is the one you want to delete proceed to step 5 To select another wipe area to delete click on Open in the screen tool bar The Wipe Area Selection...

Страница 70: ...1 INTRODUCTION Figure 6 4 The Background LLD Screen WIPE TEST 6 6 ...

Страница 71: ...s manual 7 Once all parameters have been set click on Ok to return to the Wipe Counting screen BACKGROUND Before performing a wipe test the system must perform a daily background count The system requires that you count background a minimum of one time per day If the background changes dramatically in a facility during the day it is recommended to recount your background at the appropriate interva...

Страница 72: ...1 INTRODUCTION WIPE TEST 6 8 Figure 6 5 The Wipe Results Report ...

Страница 73: ...his area 6 Once the wipe test is completed the results of that wipe location are stored by date and time until that particular wipe is recounted The screen displays the results in cpm next to each isotope in the isotope display window The last isotope spectrum counted will be displayed at the top of the screen with the ROI cpm shown to the right of the spectrum on the lower part of the screen To t...

Страница 74: ... Test mode the activity shown is NET activity This means that the background count is subtracted from the count before the activity is calculated For all other modes counts shown are the actual counts detected and are not netted for background NOTE You must use the Isotope Editing screen to make isotopes available for Bioassay use and the Isotope Efficiencies screen to enter the Detector Efficienc...

Страница 75: ... the Isotopes for Assay Window highlight the desired isotope and click on Remove 5 Select the Detector and Activity Units 6 Set the appropriate counting times 7 Set Geometric Efficiency 8 Set the Trigger Level 9 After all parameters are set click on OK The system returns to the Bioassay screen NOTE If you have not yet performed a background count on this date you must do so before proceeding with ...

Страница 76: ...1 INTRODUCTION 7 3 BIOASSAY Figure 7 2 The Bioassay Preferences Screen ...

Страница 77: ...rd number you can see the record number increase or decrease and display the appropriate results for each test NOTE In order to count a patient in Bioassay you must select that patient in the Patient Definition window Select an existing procedure for the patient then click on Bioassay to display that patient and any test data The Bioassay information is not listed as a test having been performed i...

Страница 78: ...7 5 BIOASSAY CONTENTS Figure 7 3 An Individual Bioassay Report ...

Страница 79: ...CONTENTS Figure 7 4 An Employee Bioassay Summary BIOASSAY 7 6 ...

Страница 80: ...1 INTRODUCTION 7 7 BIOASSAY Figure 7 5 An Individual Bioassay History Summary ...

Страница 81: ...ox 4 Select the appropriate detector 5 Select the Schillings Kit that you wish to use 6 Enter the counting time 7 Enter the proper correction factor 8 Enter the sample volume to be counted 9 Click Save to save the information NOTE To change any information click on Open Select the appropriate type of procedure whether it is Thyroid Uptake Schillings or Hematology and then select the appropriate st...

Страница 82: ...1 INTRODUCTION SCHILLING TESTS 8 2 Figure 8 1 Defining a Facility Standard Schilling Test ...

Страница 83: ...CONTENTS 8 3 SCHILLING TESTS Figure 8 2 The Schillings Counting Page ...

Страница 84: ...CONTENTS SCHILLING TESTS 8 4 Figure 8 3 A sample Schillings Mallinckrodt Report ...

Страница 85: ...ed NOTE If an error was made in the total urine volume do not click Save You can go back and click on Preferences to correct the error as long as you have not saved 10 Once you have finished with any recounts for this patient select Save to display the Verify Test Complete screen If the numbers are satisfactory click Yes to save the results 11 To print results at any time click on the Print icon T...

Страница 86: ...The system automatically counts background for both Co 57w and Co 58w 11 Remove the tube used for background counting and place the Co 58 standard into the well counter 12 Click on the Co 58 standard button The system will now count the Co 58 standard and record the count in the Co 58w window The system next automatically counts the Co 57w window using the Co 58 source to calculate spill down NOTE...

Страница 87: ...CONTENTS 8 7 SCHILLING TESTS Figure 8 4 The Diopac Schillings Counting Page ...

Страница 88: ...SCHILLING TESTS 8 8 CONTENTS Figure 8 5 A Sample Diopac Schillings Report ...

Страница 89: ...oceed to the Hematology Counting page You can now proceed to the appropriate test as described below IHSA I 125 See Figure 9 1 and 9 2 To perform an IHSA I 125 study follow the kit instructions for preparing and administering the dose When preparing to count the different parts of the study be sure to have all the vials set up so they can be counted one after the other to negate any decay factors ...

Страница 90: ...CONTENTS HEMATOLOGY 9 2 9 1 The IHSA Counting Page ...

Страница 91: ...time that you will use for each of the items into the procedure definition Once this time is set and you save it all Cr 51 blood volume tests will use this counting time unless adjusted 1 At the Cr 51 blood volume counting page verify that the patient Name and patient s ID at the top of the screen are correct 2 Click on Preferences and enter the patient hematocrit number as a percentage Also enter...

Страница 92: ...1 INTRODUCTION HEMATOLOGY 9 4 Figure 9 2 A Sample IHSA I 125 Test Report ...

Страница 93: ...CONTENTS 9 5 HEMATOLOGY Figure 9 3 The CR 51 Counting Page ...

Страница 94: ...icked No you can now place the appropriate vial into the well and press the corresponding button to recount that vial When the system is done it will display the Verified Test Complete window again and you can save or not save at that point NOTE If you did not save and you are looking at the Cr 51 main screen you can save by pressing the Save button which will display the Verified Test Complete sc...

Страница 95: ...CONTENTS 9 7 HEMATOLOGY Figure 9 4 A Sample Cr 51 Volume Test Report ...

Страница 96: ...CONTENTS Figure 9 5 The Cr 51 Red Blood Cell Survival Counting Page HEMATOLOGY 9 8 ...

Страница 97: ... or decrease the numbers as desired Once you have set the count time and the number of samples click OK You can now proceed to count 4 Put the background vial into the well counter and click Background The system will count the background for the pre determined time When done the counts per minute and the counting time plus the time date that background was counted will be displayed 5 After backgr...

Страница 98: ...CONTENTS HEMATOLOGY 9 10 Figure 9 6 A sample Cr 51 Survival Test Report ...

Страница 99: ... standard to dilution ratio and quantity used to count for both the standard and the ultra filtrate If you wish to enter any parameter it should be done before counting Now click OK to close the GFR parameters window Any changes will now be implemented 4 Clear away any radioactive sources from near the well counter If you have not calibrated the well counter today do so now 5 Place a test tube or ...

Страница 100: ...CONTENTS Figure 9 7 The GFR Counting Page HEMATOLOGY 9 12 ...

Страница 101: ...dow Any changes will now be implemented 4 Clear away any radioactive sources from near the well counter If you have not calibrated the well counter today do so now 5 Place a test tube or vial similar to what you were using for the other samples to be tested into the well counter This will be used for background testing 6 Click on the Background button and the system will proceed to count backgroun...

Страница 102: ...e the ability to recount any of the various items counted or change the times 15 Once you have recounted or corrected anything click on Save to bring up the Verified Test Complete screen Click on OK to save This will prevent any data for this patient from being lost or having someone else inadvertently count over the values 16 To print the results click on the Printer icon If desired the results c...

Страница 103: ...1 INTRODUCTION 9 15 HEMATOLOGY Figure 9 8 A One Sample Glomerular Filtration Rate Report ...

Страница 104: ...1 INTRODUCTION HEMATOLOGY 9 16 Figure 9 9 A Two Sample Glomerular Filtration Rate Report ...

Страница 105: ...ounter Click Background to begin counting background When done counting the system displays the counts and the CPM 5 Click on Injection and enter the time that the Mag 3 was injected into the patient Click OK to return to the counting page 6 Remove the vial for background from the well counter and insert the standard counting vial into the well Click on Standard count the standard for the designat...

Страница 106: ...1 INTRODUCTION HEMATOLOGY 9 18 Figure 9 10 The ERPF Counting Page ...

Страница 107: ... count and CPM will be displayed and entered on the system 7 Click on Time Sample 1 to display the window for entering the blood sample withdrawal time Once you have entered the correct blood withdrawal time click OK and proceed with the study NOTE It is recommended to save test results before leaving this patient and screen 8 Remove the standard from the well and place the sample into the well Cl...

Страница 108: ...1 INTRODUCTION HEMATOLOGY 9 20 Figure 9 10 The ERPF Counting Page ...

Страница 109: ...1 INTRODUCTION 9 21 HEMATOLOGY Figure 9 11 An Effective Renal Plasma Flow Report ...

Страница 110: ...he set up associated with the detector in the wipe and bioassay programs is automatically altered to match It is vital that you verify the correct geometric efficiency to ensure readings obtained in the wipe and bioassay programs will be correct A Geometric Efficiency G E The value for Geometric Efficiency G E is calculated from the following equations for a well and probe WELL I D Inner diameter ...

Страница 111: ...ource preparation is outlined on the next page The liquid source will be deposited on an absorbent material in the bottom of a plastic vial which fits inside the well It is recom mended that no more than 10 ul of liquid be dispensed in order to reduce spilling radioactive material NOTE If a probe is being tested for efficiency a method for holding the source or vial in proximity of the probe appro...

Страница 112: ... Show Current Activity button the unit displays the calculated decayed activity of the standard you created 5 Now near the bottom of the display screen click the mouse on the well 6 Perform an automatic 100 second background count with an empty well by clicking on the Calculate Efficiency button to the right of the displayed detector efficiency values 7 When the background count is completed if yo...

Страница 113: ...ibrator and the same of counting the source in the well detector Both should have the same units as T1 2 For example If T 08 31 h and t 15 49 h then T t 7 300 h If T1 2 3 261 days for Ga 67 then T t should be converted to days 0 3041 days In this case the decay result would be 0 937 11 Calculate D E from the composite D E G E found in step 10 above and from the calculated value of G E found earlie...

Страница 114: ...he photon emission from Am 241 are 59 5 keV at 35 9 intensity and 26 3 keV at 2 4 intensity The interaction probability for a 60 keV photon is very high in the Nal well detector Nal thickness on sides and bottom is about 0 625 inches the bulk of this interaction will be photoelectric which puts most of the counts recorded in the photo peak The ROI is set to integrate the photo peak of 59 5 keV The...

Страница 115: ...teraction in the detector will produce counts which integrate to a fraction of the total number of photons passing through the detector This will always be less than 100 and will depend upon the window thickness which the photon detector must pass through detector crystal geometry and the photon energy This photon interaction has been calculated using Nal TL SCINTILLATION DETECTORS published by Bi...

Страница 116: ...b products Thyroid Uptake Models 930 and 950 Wipe Test Counter Model 450 Probe Well Isotope Left ROI Right ROI Efficiency Efficiency Na 24 1162 3167 7 8 K 42 1296 1754 0 9 0 4 Cr 51 272 368 6 7 4 5 Co 57 103 158 93 8 92 8 Co 58 434 933 24 1 Co 60 997 1533 14 2 Fe 59 934 1486 7 7 3 8 Ga 67 79 345 72 8 Se 75 102 461 148 9 Sr 85 437 591 32 6 18 2 Tc 99m 119 162 84 3 82 3 Pd 103 17 27 62 3 62 3 In 111...

Страница 117: ...est Hematology Administration QA Manual MCA Radionuclides Factory Programmed Au 198 Ba 133 Co 57 Co 58 Co 60 Cr 51 Cs 137 Fe 59 Ga 67 Hg 197 I 123 I 125 I 131 In 111 Ir 192 K 42 Na 24 Pd 103 Se 75 Sr 85 Tc 99m TI 201 Yb 169 User Set Unlimited user defined isotopes setting ROI half life name efficiency and gain OTHER HARDWARE Probe 2 x 2 Nal T1 integral line scintillation detector with tube base Up...

Страница 118: ...ed Immunity 80 MHz to 2500 MHz 3v m Horiz no degradation complied Vertical 1M of performance IEC 61000 4 4 Electrical Fast Transient PWR Input leads 5 1 2 Kv pos no degradation complied Burst Power Leads neg 5KHz Rep Rate of performance IEC 61000 4 6 Conducted Immunity 150 KHz to 80 MHz 3Vrms no degradation complied Power Leads of performance IEC 61000 4 8 Magnetic Immunity 3A M RMS 50 60 Hz no de...

Страница 119: ...Schematics provided on the following pages include Schematics Controller Schematics MCA 95 Assembly PC Board PC Based Spectrometer 950 and 950CE Assembly PCB MCA SCHEMATICS S 1 SCHEMATICS ...

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