Waters Xevo G2 QTof, Operator'S, Overview And Maintenance Manual, Page: 32 / 248

1-14 Waters Xevo G2 QTof Overview
Ion optics
The mass spectrometer’s ion optics operate as follows:
1. Samples from the LC or instrument’s solvent delivery system are
introduced at atmospheric pressure into the ionization source.
2. The ions pass through the sample cone into the vacuum system.
3. The ions pass through the hexapole to the quadrupole, where they are
filtered according to their mass-to-charge ratio.
4. The mass-separated ions pass into the T-Wave™ collision cell, where
they can undergo collision-induced dissociation (CID).
5. The ions then pass into the time-of-flight (ToF) analyzer. A high voltage
pulse orthogonally accelerates the ions up the flight tube, where a
reflectron reflects them back again towards the detector. Ions of
different mass-to-charge ratios arrive at the detector at different times,
hence a mass spectrum can be created.
6. The signal from the detector is amplified, digitized, and sent to the
software.
Ion optics overview:
Sample sprayer
Pusher Detector
DRE lens
Quadrupole
Hexapole
Lock-spray sprayer
Transfer lenses
T-Wave collision cell
Sample cone
Isolation valve
Reflectron
Flight tube