iv
Safety considerations
Some reagents and samples used with Waters
®
instruments can pose
chemical, biological, and radiological hazards. Be sure you are aware of the
potentially hazardous effects of all substances you work with. Always observe
Good Laboratory Practice (GLP) guidelines, published by the U.S. Food and
Drug Administration, and consult your organization’s safety representative
for guidance.
When you develop methods, follow the “Protocol for the Adoption of Analytical
Methods in the Clinical Chemistry Laboratory,” American Journal of Medical
Technology, 44, 1, pages 30–37 (1978). This protocol addresses good operating
procedures and the techniques necessary to validate system and method
performance.
Instrument-specific safety considerations
Solvent leakage hazard
The source exhaust system is designed to be robust and leak-tight. Waters
recommends you perform a hazard analysis, assuming a maximum leak into
the laboratory atmosphere of 10% HPLC eluate.
Warning:
• To confirm the integrity of the source exhaust system, the
source seals must be renewed at intervals not exceeding one
year.
• The source seals can withstand exposure only to specific
solvents, see Appendix C in the Waters TQ Detector Operator’s
Guide. If you intend to use solvents other than those listed,
you must first determine whether those solvents are
compatible with the composition of the seals.