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Waters TQ Detector Overview
Constant neutral loss mode:
Typical application
You typically use constant neutral loss mode to screen mixtures for a specific
class of compound that is characterized by a common fragmentation pathway,
indicating the presence of compounds containing a common functional group.
Sample inlet
Either of two methods delivers solvent and sample to the installed probe:
•
An LC system, which delivers the eluent from an LC analysis.
•
IntelliStart fluidics system, which uses on-board solutions to automate
instrument optimization. You can deliver solutions by direct or
combined infusion.
Vacuum system
An external roughing (rotary vane) pump and an internal split- flow
turbomolecular pump combine to create the source vacuum. The
turbomolecular pump evacuates the analyzer and ion transfer region.
Vacuum leaks and electrical or vacuum pump failures cause vacuum loss,
which protective interlocks guard against. The system monitors
turbomolecular pump speed and continuously measures vacuum pressure
with a built-in Pirani gauge. The gauge also serves as a switch, discontinuing
operation when it senses vacuum loss.
A vacuum isolation valve isolates the source from the mass analyzer, allowing
routine source maintenance without venting.
MS1
Scanning
(synchronized with MS2)
Collision cell
Pass all masses
MS2
Scanning
(synchronized with MS1)