Waters ACQUITY UPLC I-Class IVD Overview And Maintenance Manual Download Page 92

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A Safety Advisories

September, 2019, 715003738IVD Rev. C

Electrical and handling symbols

Electrical symbols

The following electrical symbols and their associated statements can appear

in instrument manuals and on an instrument’s front or rear panels.

Electrical power on

Electrical power off

Standby

Direct current

Alternating current (single phase)

Protective earth terminal

Frame or chassis ground

Fuse

Summary of Contents for ACQUITY UPLC I-Class IVD

Page 2: ...ii Rev C 715003738IVD...

Page 3: ...T S POSSIBLE are trademarks of Waters Corporation PEEK is a trademark of Victrex Corporation Phillips is a trademark of Phillips Screw Company TORX is a trademark of Textron Corporation Other register...

Page 4: ...ces you work with Always follow good laboratory practice and consult your organization s safety representative for guidance Telephone and fax From the USA or Canada phone 800 252 HPLC 800 252 4752 or...

Page 5: ...ICES 001 Cet appareil num rique de la classe A est conforme la norme NMB 001 Electrical power safety notice Do not position the instrument so that it is difficult to operate the disconnecting device W...

Page 6: ...mpaired Safety advisories Consult Appendix A for a comprehensive list of warning and caution advisories Operating this device When operating this device follow standard quality control QC procedures a...

Page 7: ...ithin the product are likely to be discarded or degrade into the environment Consult instructions for use Alternating current Electrical and electronic equipment with this symbol may contain hazardous...

Page 8: ...ructions Quality control Routinely run three QC samples that represent subnormal normal and above normal levels of a compound If trays are the same or very similar vary the location of the QC samples...

Page 9: ...Group 1 Class B This classification has been assigned in accordance with IEC CISPR 11 Industrial Scientific and Medical ISM instruments requirements Group 1 products apply to intentionally generated...

Page 10: ...anufacturing information Australian sponsor information Waters Corporation 34 Maple Street Milford MA 01757 USA Australian Sponsor Emergo Australia Level 20 Tower II Darling Park 201 Sussex Street Syd...

Page 11: ...emissions notice v Electrical power safety notice v Safety hazard symbol notice vi Equipment misuse notice vi Safety advisories vi Operating this device vi Applicable symbols vi Audience and purpose v...

Page 12: ...quired tools 38 Installing the optional in line filter 41 Required materials 42 Required tools 42 Installing the column 44 Required materials 44 Required tool 44 3 Using the column heater 49 Resolving...

Page 13: ...ls 77 Required tools 77 Cleaning the instrument s exterior 79 A Safety Advisories 81 Warning symbols 81 Specific warnings 83 Burst warning 83 Biologically hazardous materials warning 83 Biologically h...

Page 14: ...xiv September 2019 715003738IVD Rev C Electrical specifications 96 Performance specifications 97 Wetted materials of construction 98...

Page 15: ...such as those caused by air conditioning or heating affect the performance of the column preheater also known as a stablilizer Ensure that the temperature limits you set are in accordance with your an...

Page 16: ...ses an electric heating element to directly heat the column inlet tubing The rapid heating low volume design reduces gradient delay and extra column bandspreading It ensures that high flow rate separa...

Page 17: ...ss spectrometer you can mount the assembly on an external bracket on the right hand side of the chassis In line filter Protects the analytical column against contamination by trapping impurities befor...

Page 18: ...e solvent enters the column Originally used in the ACQUITY UPLC system the column stabilizer can be useful when you transfer methods from that system Drip tray Captures any leakage from the column or...

Page 19: ...itting hole before tightening the compression screw For easier accessibility use long compression screws to attach tubes to the injector and vent valve Contents Topic Page Installation recommendations...

Page 20: ...ve preheater s reusable compression fitting in place and rotate the column or in line filter onto the fitting When tightening system fittings consult the following table Installation recommendations f...

Page 21: ...plus 3 4 turn using wrench Reinstalled Stainless steel gold plated fitting with long flats and 2 piece stainless steel ferrule Finger tight plus up to 1 6 turn using wrench Installation recommendatio...

Page 22: ...ainless steel cap nut from the gold fitting 2 Finger tighten the gold fitting with the ferrule into the column Requirement If you are reinstalling the fitting replace the PEEK ferrule 3 Rotate the col...

Page 23: ...en end wrench 4 mm open end wrench 3 mm hex wrench Phillips screwdriver Small flat screwdriver T20 TORX driver Process for installing the MS bracket Task See Remove the column heater from the device c...

Page 24: ...burn injuries set the column temperature to Off and then allow the column compartment and its components to cool for 60 minutes before touching them Monitor the column compartment s internal temperatu...

Page 25: ...remove the column To install the MS bracket on the column heater chassis 1 Using a small screwdriver gently pry out the active preheater retainer and remove it from the column compartment 2 Slide the...

Page 26: ...hand side of the column heater just behind the eCord receptacle 6 Remove the column heater chassis by gently pulling it toward you with your left hand while releasing the lock with your right hand 7...

Page 27: ...t secures the column heater s rear enclosure to the sample manager chassis c Remove the column heater s rear enclosure from the sample manager s chassis d Secure the retainer bracket supplied in the c...

Page 28: ...n the chassis f Install the Phillips screw that secures the column heater s rear enclosure to the chassis g Replace any other instruments and the solvent tray above the column heater s rear enclosure...

Page 29: ...n the slot as you guide the tab into the cutout If the cable slips out of the slot it can prevent the bracket from seating fully into the chassis d Tighten the TORX screw in the tab e Tighten the 3 mm...

Page 30: ...TORX screws that secure the hinge to the MS bracket b Using two TORX screws attach the hinge assembly on the column heater housing to the height adjustment bracket c Swing the column heater housing a...

Page 31: ...of the MS bracket drip tray and slide the leak sensor into place b Route the leak sensor cable through the slot in the column heater housing 3 Secure the 25 pin cable a Insert the 25 pin cable into t...

Page 32: ...the left hand side of the column heater into the slot on the left hand side of the housing b Hold the left hand side of the column heater into the slot and guide the eCord tab on the right hand side...

Page 33: ...ocket 6 If you installed the optional leak sensor plug the connector into the receptacle located behind the column heater 7 Swing the column heater into the operating position 8 Push the drain tubing...

Page 34: ...hand side of the column compartment until it snaps into place b Install the active preheater assembly in the retainer To install the column in the column tray and connect inlet and outlet tubing 1 Sn...

Page 35: ...t the column inlet to the active preheater by holding the active preheater s reusable compression fitting in place rotating the column onto the fitting until it is snug and then tightening an addition...

Page 36: ...element through the thermal gasket to the column inlet tubing The looped tubing path reduces dispersion while ensuring maximum surface area contact between the tubing and the column tray maximizing h...

Page 37: ...ass IVD system Requirement You must remove the active preheater assembly before installing the column stabilizer assembly For instructions on how to replace the column stabilizer assembly see page 73...

Page 38: ...ng for connecting the column to the MS flow cell Three Phillips screws one is a spare Three thermal gaskets two are spares Required tools Needle nose pliers Phillips screwdriver To install the optiona...

Page 39: ...ose pliers gently compress the top and bottom of the active preheater retainer and pull it out of the column compartment 6 Remove the clear protective backing from the thermal gasket and with the ther...

Page 40: ...ly press the column stabilizer assembly into the thermal gasket ensuring that the thermal gasket uniformly envelops the sides of the column stabilizer and does not bunch beneath it Column stabilizer a...

Page 41: ...e the tubing behind the sample manager door hinge 12 Remove the O ring retainer from the inlet end of the column stabilizer inlet tubing and then connect the inlet tubing to injector port 6 of the sam...

Page 42: ...re that the ferrule is approximately 3 mm from the end of the outlet tubing and that the collet is touching the back of the ferrule Warning To avoid burn injuries set the column temperature to Off and...

Page 43: ...r inlet until it stops Installing the in line filter 3 Holding the reusable fitting in place rotate the in line filter unit onto the fitting until it is snug 4 Finger tighten the fitting until it is s...

Page 44: ...h the outlet end of the column in line filter unit into the column inlet until it stops Warning To avoid burn injuries set the column temperature to Off and then allow the column compartment and its c...

Page 45: ...e high temperature outlet fitting into the column outlet until it is finger tight 3 Using a 5 16 inch wrench to hold the column steady use the high temperature outlet fitting wrench to give the outlet...

Page 46: ...es the type of MS and flow cell in your system 3 Attach the 0 004 inch or 0 0025 inch ID inlet tubing included with the flow cell or the stabilizer kit to the column outlet 4 Snap the column support c...

Page 47: ...er before you connect or disconnect the external communication cable between the sample manager and the column heater Caution To avoid damage to the components power off the sample manager before you...

Page 48: ...2 Preparing the column heater 48 September 2019 715003738IVD Rev C...

Page 49: ...nition temperatures are below 150 C Warning To avoid breathing harmful fumes or vapors when using hazardous solvents run the system in a hooded environment that provides a sufficient air exchange rate...

Page 50: ...pen the column heater s door Otherwise see the Resolving leak sensor errors section in the Sample Manager Operator s Overview and Maintenance Information document 3 Locate the source of the leak and r...

Page 51: ...lumn outlet PEEK tubing from the detector inlet 6 Remove any solvent tubing routed behind the column heater door 7 Power off the sample manager and detach the leak sensor connector from the front of t...

Page 52: ...the leak sensor from its reservoir grasping it by its serrations and pull upward on it tilting it to the left hand side Tip If you cannot easily manipulate the leak sensor after removing it from its...

Page 53: ...C 53 11 Use a nonabrasive lint free wipe to dry the leak sensor prism 12 Roll up a nonabrasive lint free wipe and use it to absorb the liquid from the leak sensor reservoir and its surrounding area T...

Page 54: ...d from the corners of the leak sensor reservoir and its surrounding area 14 Align the leak sensor s T bar with the slot in the side of the leak sensor reservoir and slide the leak sensor into place Co...

Page 55: ...3738IVD Rev C 55 15 If you detached the connector from the front of the instrument reattach it and power on the sample manager 16 In the ACQUITY UPLC Console select Sample Manager FTN from the system...

Page 56: ...3 Using the column heater 56 September 2019 715003738IVD Rev C...

Page 57: ...Y UPLC Console online Help Under normal operating conditions the column compartments do not require any maintenance If residue from solvent leaks accumulates in the column compartment remove the colum...

Page 58: ...ce based on system usage see page 63 Recommended routine maintenance schedule Maintenance procedure Frequency For information Replace the leak sensor on the column heater As needed For example when th...

Page 59: ...tive preheater assembly connections and or replace the ferrules Split peaks Reseat the active preheater assembly connections and or replace the ferrules See page 70 Replace the column stabilizer assem...

Page 60: ...er unit As needed The typical failure modes are as follows High back pressure The column in line causes a high pressure shutdown In this case disconnect the in line filter If the system exhibits press...

Page 61: ...rs Quality Parts Visit www waters com wqp for information about Waters Quality Parts including how to order them Warning To avoid the harmful effects of personal contact with solvents including inhala...

Page 62: ...version For complete information on reporting shipping damages and submitting claims see Waters Licenses Warranties and Support Services documentation Locating system serial numbers The serial number...

Page 63: ...nance warnings that alert you when a component reaches the designated threshold limit By setting threshold limits and monitoring these usage counters regularly you can minimize unexpected failures and...

Page 64: ...ample manager 3 Open the sample manager door gently pulling its right hand edge toward you 4 Press down on the tab to detach the leak sensor connector from the front of the instrument 5 Disconnect the...

Page 65: ...ev C 65 7 Remove the TORX screw from the right hand side of the column heater just behind the eCord receptacle 8 Remove the column heater chassis by gently pulling it toward you with your left hand wh...

Page 66: ...Remove the leak sensor from its reservoir grasping it by its serrations and pull upward on it tilting it to the left To install a new leak sensor 1 Unpack the new leak sensor Caution To avoid damaging...

Page 67: ...leak sensor reservoir and slide the leak sensor into place 3 Plug the leak sensor connector into the front of the instrument 4 Insert the tab on the left hand side of the column heater into the slot...

Page 68: ...ocated behind the eCord receptacle 7 Connect the column inlet active preheater or column stabilizer tubing to injector port 6 of the sample manager 8 Connect the column outlet PEEK tubing to the MS in...

Page 69: ...following a Remove the active preheater assembly from the retainer b While holding the column disconnect the column outlet tubing Warning To prevent burn injuries set the column temperature to Off and...

Page 70: ...ollet separator over the collet on the column stabilizer tubing and gently move it back and forth to pry the reusable fitting loose from the collet Older reusable fittings do not have holes in their s...

Page 71: ...injector port 6 of the sample manager Warning To avoid burn injuries set the column temperature to Off and then allow the column compartment and its components to cool for 60 min before touching them...

Page 72: ...sembly to the optional in line filter or to the column To install the new active preheater assembly 1 Loosen the stainless steel cap nut from the gold fitting 2 Finger tighten the gold fitting with th...

Page 73: ...urn injuries set the column temperature to Off and then allow the column compartment and its components to cool for 60 minutes before touching them Monitor the column compartment internal temperature...

Page 74: ...inlet tubing from injector port 6 of the sample manager 3 Open the column heater door 4 Using the Phillips screwdriver loosen the two screws that fasten the column stabilizer assembly to the column c...

Page 75: ...ermal gasket Ensure that the thermal gasket uniformly envelops the sides of the column stabilizer and does not bunch beneath it Column stabilizer assembly two styles TP03425 Column stabilizer inlet tu...

Page 76: ...r to the injector Requirement Do not route the tubing behind the sample manager door hinge 5 Remove the O ring retainer from the inlet end of the column stabilizer tubing Then connect the inlet tubing...

Page 77: ...it Required materials Gloves clean powder free chemical resistant Replacement frit Required tools 5 16 inch open end wrench 2 To replace the frit in the in line filter unit 1 After allowing sufficient...

Page 78: ...r unit by placing two 5 16 inch open end wrenches onto the flats as shown 5 Remove the in line filter unit inlet nut which contains the used frit Tips Discard the frit it cannot be reused Over time th...

Page 79: ...mbled components to the column compartment Cleaning the instrument s exterior Clean surfaces of the solvent manager using only a clean soft lint free paper or clean cloth dampened with water Warning T...

Page 80: ...4 Maintenance Procedures 80 September 2019 715003738IVD Rev C...

Page 81: ...ls Warning symbols alert you to the risk of death injury or seriously adverse physiological reactions associated with an instrument s use or misuse Heed all warnings when you install repair or operate...

Page 82: ...ment s user documentation for important safety related information before you use the instrument Warning Risk of burn injury from contacting hot surfaces Warning Risk of electric shock Warning Risk of...

Page 83: ...uish all nearby flames Do not use tubing that is or has been stressed or kinked Do not expose nonmetallic tubing to incompatible compounds like tetrahydrofuran THF and nitric or sulfuric acids Be awar...

Page 84: ...Warning To avoid personal contamination with biologically hazardous toxic or corrosive materials you must understand the hazards associated with their handling Guidelines prescribing the proper use a...

Page 85: ...de la conformit la r glementation peut annuler le droit de l utilisateur exploiter l quipement Achtung Jedwede nderungen oder Modifikationen an dem Ger t ohne die ausdr ckliche Genehmigung der f r die...

Page 86: ...se trouvant proximit de l instrument Evitez d utiliser des tubes s v rement d form s ou endommag s Evitez d utiliser des tubes non m talliques avec du t trahydrofurane THF ou de l acide sulfurique ou...

Page 87: ...l dimetilsolfossido provocano rigonfiamenti nei tubi non metallici riducendo notevolmente la pressione di rottura dei tubi stessi Advertencia se recomienda precauci n cuando se trabaje con tubos de po...

Page 88: ...A Safety Advisories 88 September 2019 715003738IVD Rev C Nonmetallic Tetrahydrofuran THF Methylene chloride Dimethyl sulfoxide THF...

Page 89: ...e par le mat riel risque d tre d fectueuses Vorsicht Der Benutzer wird darauf aufmerksam gemacht dass bei unsachgem er Verwenddung des Ger tes die eingebauten Sicherheitseinrichtungen unter Umst nden...

Page 90: ...u type et de la puissance indiqu s sur le panneau proximit du couvercle de la boite fusible de l instrument Vorsicht Zum Schutz gegen Feuer die Sicherungen nur mit Sicherungen ersetzen deren Typ und N...

Page 91: ...s la rubrique Rem placement des fusibles du chapitre traitant des proc dures de maintenance Vorsicht Zum Schutz gegen Feuer die Sicherungen nur mit Sicherungen ersetzen deren Typ und Nennwert im Absch...

Page 92: ...ymbols The following electrical symbols and their associated statements can appear in instrument manuals and on an instrument s front or rear panels Electrical power on Electrical power off Standby Di...

Page 93: ...5003738IVD Rev C 93 Handling symbols The following handling symbols and their associated statements can appear on labels affixed to the packaging in which instruments devices and component parts are s...

Page 94: ...A Safety Advisories 94 September 2019 715003738IVD Rev C...

Page 95: ...l information about specifications Physical specifications The following table lists the physical specifications for the ACQUITY UPLC I Class IVD column heater Contents Topic Page Physical specificati...

Page 96: ...Attribute Specification Operating temperature 4 to 40 C 39 2 to 104 F Operating humidity 20 to 80 noncondensing Transportation and storage temperature 30 to 60 C 22 to 140 F Transportation and storage...

Page 97: ...mass spectrometer Fittings 124 106 kPa 1241 bar 18 000 psi low dispersion with reusable column inlet fittings Column compartment temperature range 20 to 90 C in increments of 0 1 C control requires a...

Page 98: ...w Measurement taken with traceable external temperature measurement device Measurement taken after one hour of thermal equilibration at setpoint Measurement taken at column compartment sensor location...

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