WATERS CORPORATION TQ, Operator'S Manual, Page: 27 / 192

MS/MS operating modes
December 6, 2012, 71500126802IVD Rev. C 27
MS/MS operating modes
The following table shows the MS/MS operating modes.
Product (daughter) ion mode
Product ion mode is the most commonly used MS/MS operating mode. You can
specify an ion of interest for fragmentation in the collision cell, thus yielding
structural information.
Product ion mode
Typical applications
Product ion mode is typically used for the following applications:
• Method development for MRM screening studies:
MS/MS operating modes
Operating mode MS1 Collision cell MS2
Product
(daughter) ion
spectrum
Static (at
precursor mass)
Pass all masses Scanning
Precursor
(parent) ion
spectrum
Scanning Static (at product
mass)
MRM Static (at
precursor mass)
Static (at product
mass)
Constant neutral
loss spectrum
Scanning
(synchronized
with MS2)
Scanning
(synchronized
with MS1)
MS1
Static (at precursor mass) MS2
Scanning Collision cell
Pass all masses