Thermo Scientific Vanquish VH-P10-A-02, Operating Manual

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2 • Safety
Vanquish Pumps (VH-P10-A-02) Operating Manual Page 27
2.4 Solvent and Additive Information
To protect optimal functionality of the Vanquish system, observe these
recommendations on the use of solvents and additives:
• The system must be used with reversed-phase (RP) compatible
solvents and additives only.
•
Use only solvents and additives that are compatible with all parts in
the flow path.
For details about the materials that are used in the flow path of the
pump, see the
Specifications
chapter. For information about the
materials that are used in the flow path of the other modules in the
Vanquish system, refer to the
Specifications
chapter in the
Operating Manual
for the module.
Observe the general guidelines and recommendations on the use of
solvents and additives in the chromatography system (see
section 6.5, page 89 ).
• Allowed ranges and concentrations (standard system configuration):
♦
pH range: 2-12
♦
Chloride concentration: 1 mol/L or less
•
Observe the following:
♦
pH values higher than 9.5 with optical detectors
Avoid using mobile phases with a pH value higher than 9.5
together with optical detectors. This can impair the functionality
and optical performance of the detector flow cell.
♦
pH values of 2 or less or high chloride concentration
With pH values of 2 or less or high chloride concentration, the
application time should be as short as possible. Flush the system
thoroughly after these applications.
♦
Mobile phases containing ammonium hydroxide
In rare cases, a shortened lifetime of reversed-phase (UHMW-
PE) piston seals has been observed with high pH, ammonium
hydroxide containing mobile phases and prolonged exposure.