Thermo Scientific Vanquish VF-D20, Operating Manual, Page: 103 / 182

6 • Operation
Vanquish Charged Aerosol Detectors Operating Manual Page 103
6.7 Optimizing the Performance of the Detector
This section provides information for best performance of the detector
and gives hints on what you can do to optimize the performance further.
For information on the default parameters, see section 6.6 Important
Operating Parameters, page 100 .
6.7.1 General Guidelines
Consider the following guidelines for optimization of the detector
performance:
•
Consider the influences of the parameters on the detection (see
section 6.7.2 Overview of Optimization Parameters, page 104 ).
•
Ensure that the operating conditions are suitable. This includes:
♦
Stable environmental conditions, such as a stable temperature
♦
No air drafts
♦
No vibrations or mechanical shocks caused by external sources
♦
Stable backpressure and correct waste line setup
•
Degas the solvent in the Vanquish pump.
•
Monitor the usage of specific detector components that are subject
to wear and stress and schedule appropriate maintenance intervals
(see
section 7.4.4 Predictive Performance, page 123 ).
• For guidelines and recommendations on the use of mobile phases
with the charged aerosol detector, see
section 6.5.1, page 95 .
•
Maintain the nitrogen or air source for your detector at regular
intervals to ensure optimum performance. Observe the instructions
in the
User Documentation for the nitrogen generator
.
•
Use a dedicated column for each specific analysis to avoid cross-
contamination of the column.
•
Do not use a column that has been used with non-volatile mobile
phases.
• Columns that are unstable and/or have a tendency to release
particles from the column bed (i.e. "column bleed") will produce
noise in the detector. Avoid such columns.