6
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Operation
Page 98
UHPLC System
Operating Manual
Interupting Operation of the System for a Longer Period
To interrupt operation for a longer period, follow the instructions below.
Also observe the instructions and guidelines for the long-term shutdown
of the in the Operating Manual for each module.
1. Remove the column.
2. Flush the system with an appropriate solvent (minimum HPLC-
grade). Observe the following:
TIP
With a Vanquish Core system that has been modified for using
normal-phase compatible solvents and additives, see the information
about the flushing liquid in the
Considerations with Normal-Phase
Compatible Solvents and Additives
section in
Operating Manual
for the
pump.
Situation after Shutdown
If no additive is used
If an additive is used
System remains in the
laboratory after shutdown
Flush the system, for
example with methanol.
100% acetonitrile should
not be used.
Flush the system with
several volumes of
methanol and water
(50:50) (for example,
1.0 mL/min for
10 minutes with the
standard system) to
prevent salt buildup in the
fluidics. If the solvents in
the device are not
miscible with water, use
an appropriate
intermediate solvent.
System shall be
transported or shipped
after shutdown
Flush the system with
isopropanol.
Flush the system first with
several volumes of
methanol and water
(50:50) (for example,
1.0 mL/min for
10 minutes with the
standard system) to
prevent salt buildup in the
fluidics. If the solvents in
the device are not
miscible with water, use
an appropriate
intermediate solvent.
Afterward, flush the
system with isopropanol.
Summary of Contents for thermoscientific Vanquish UHPLC System
Page 4: ...Contacting Us Page 4 UHPLC System Operating Manual ...
Page 28: ...2 Safety Page 28 UHPLC System Operating Manual ...
Page 34: ...3 System Overview Page 34 UHPLC System Operating Manual ...
Page 38: ...4 Unpacking Page 38 UHPLC System Operating Manual ...
Page 82: ...5 Installation Page 82 UHPLC System Operating Manual ...
Page 100: ...6 Operation Page 100 UHPLC System Operating Manual ...
Page 112: ...7 Maintenance and Service Page 112 UHPLC System Operating Manual ...
Page 128: ...8 Troubleshooting Page 128 UHPLC System Operating Manual ...
Page 132: ...9 Specifications Page 132 UHPLC System Operating Manual ...
Page 144: ...11 Appendix Page 144 UHPLC System Operating Manual ...