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HyPerforma Glass Bioreactor Quick Start Guide

This guide provides a brief overview of assembling and disassembling the Thermo Scientific

 HyPerforma

 

glass bioreactor. Contact your sales representative for more detailed information about this product.

Assembling the Glass Bioreactor vessel

1.  Using both hands, carefully place the glass 

vessel into the stand (Figure 1). Ensure that the 
glass vessel is centered properly.

2.  Inspect the headplate assembly, ensuring that 

the O-ring is clean, undamaged, and properly 
installed in the groove of the headplate. Install 
the headplate assembly, ensuring that the 
guide pins are aligned with the headplate 
guide holes (Figure 2). Ensure that none of 
the installations of the headplate assembly 
(cooling coil, impeller shaft, etc.) hit the glass 
rim when placing the headplate assembly 
onto the glass vessel. 

Note:

 Ensure that the 

O-ring on the flange around the glass vessel 
(as received) is intact when removing the 
headplate for cleaning purposes.

3.  Hand-tighten the four headplate retaining 

screws (Figure 2) in a cross-wise pattern. 

Note:

 The headplate retaining screws should 

only be hand-tightened; using tools to tighten 
the screws may lead to glass vessel damage.

4.  Replace any septa (Figure 2) that have been 

removed, used, or damaged.

5.  Replace the heating jacket (Figure 1) and 

ensure it is held in place with hook and loop 
fastener (Velcro

) straps. 

Note:

 Both the 

jacket and the straps 

MUST

 be under the 

stand struts (Figure 1) in order to ensure full 
contact of the jacket on the glass vessel wall.

6.  Replace the agitator motor assembly. Place 

the agitator motor assembly onto the agitator 
bearing housing so that it is fully seated on the 
headplate (Figure 1). 

Figure 1. Assembled Glass Bioreactor.

Figure 2. Close-up view of headplate.

Agitator motor 
assembly

Stand struts

Heating 
jacket

Jacket 
cable

Headplate 
assembly

Retaining 
screws

Guide pins/
holes

Septa port

Retaining 
screws

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