Thermo Scientific Corona Veo, Operating Manual

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6 • Operation
Page 144 Charged Aerosol Detectors Corona Veo (RS) Operating Manual
• Consider that higher evaporation temperature settings may
inadvertently reduce response for low-analyte levels, even if they
are considered as non-volatile analytes.
•
Remember to check the limits of sensitivity by actual analysis of low-
level standards. Also, check the analyte signal reproducibility at each
evaporation temperature setting.
•
For detection of semi-volatile analytes, you can use lower
evaporation temperature settings. However, this may lead to higher
background levels and noise.
How to optimize the evaporation temperature (Corona Veo RS only)
• Perform three or more injections of a reference standard for the
analytical method for which you want to optimize the evaporation
temperature.
• Use a different evaporation temperature setting for each reference
injection, ranging from low to high temperature. Select the most
appropriate setting as starting point. See the
Guidelines for selecting
the evaporation temperature
above.
TIP Using performance metrics such as the precision and sensitivity of
the detector can help to achieve the optimal evaporation temperature.
6.7.5 Gas Regulation Mode (Corona Veo RS Detector only)
This section applies only to the Corona Veo RS detector.
The modes are only available in the chromatography data system, such
as the Chromeleon software.
The detector provides two gas regulation modes (gas flow modes) to
optimize the efficiency of the nebulizer:
Analytical and MicroLC . Each
mode sets a specific nebulizer gas pressure for the analysis, based on the
gas pressure specified for the nebulizer from the nebulizer certificate.
The modes are designed as a simple way to optimize the nebulizer
efficiency when you use very high (analytical) or very low (microLC) flow
rates in the specified flow range for the detector. These modes of
operation are only available when you use compatible chromatography
software.