Rosemount Oxymitter 4000, Instruction Bulletin

Page: 23 / 127

IB-106-340
xix
4) Pleural plaques (thickening along the chest wall) have been observed in a small number of
employees who had a long duration of employment. There are several occupational and non-
occupational causes for pleural plaque. It should be noted that plaques are not “pre-cancer” nor
are they associated with any measurable effect on lung function.
TOXICOLOGY
A number of studies on the health effects of inhalation exposure of rats and hamsters are available.
Rats were exposed to RCF in a series of life-time nose-only inhalation studies. The animals were
exposed to 30, 16, 9, and 3 mg/m
3
, which corresponds with approximately 200, 150, 75, and 25
fibers/cc.
Animals exposed to 30 and 16 mg/m
3
were observed to have developed a pleural and parenchymal
fibroses; animals exposed to 9 mg/m
3
had developed a mild parenchymal fibrosis; animals exposed to
the lowest dose were found to have the response typically observed any time a material is inhaled into
the deep lung. While a statistically significant increase in lung tumors was observed following
exposure to the highest dose, there was no excess lung cancers at the other doses. Two rats exposed to
30 mg/m
3
and one rat exposed to 9 mg/m
3
developed masotheliomas.
The International Agency for Research on Cancer (IARC) reviewed the carcinogenicity data on man-
made vitreous fibers (including ceramic fiber, glasswool, rockwool, and slagwool) in 1987. IARC
classified ceramic fiber, fibrous glasswool and mineral wool (rockwool and slagwool) as possible
human carcinogens (Group 2B).
EMERGENCY FIRST AID PROCEDURES
EYE CONTACT
Flush eyes immediately with large amounts of water for approximately 15 minutes. Eye lids should be
held away from the eyeball to insure thorough rinsing. Do not rub eyes. Get medical attention if
irritation persists.
INHALATION
Remove person from source of exposure and move to fresh air. Some people may be sensitive to fiber
induced irritation of the respiratory tract. If symptoms such as shortness of breath, coughing,
wheezing or chest pain develop, seek medical attention. If person experiences continued breathing
difficulties, administer oxygen until medical assistance can be rendered.
INGESTION
Do not induce vomiting. Get medical attention if irritation persists.
SKIN CONTACT
Do not rub or scratch exposed skin. Wash area of contact thoroughly with soap and water. Using a
skin cream or lotion after washing may be helpful. Get medical attention if irritation persists.
SECTION VI. REACTIVITY DATA
STABILITY/CONDITIONS TO AVOID
Stable under normal conditions of use.
HAZARDOUS POLYMERIZATION/CONDITIONS TO AVOID
N.A.